OBJECTIVE：To provide reference for rational use of analgesic drugs for advanced cancer，moderate to severe pain. METHODS：The data of narcotic drugs and first type psychotropic drugs were collected from hospital information system of a third grade class A hospital during 2012-2014，and then analyzed in respects of amount，consumption sum and DDDs，etc. RESULTS： The amount of narcotic drugs and first type psychotropic drugs kept stable basically，and the consumption sum of them during 2012-2014 was 1 566 289.92 yuan，1 525 220.23 yuan and 1 531 277.44 yuan. The consumption sum of Morphine hydrochloride tablet increased the fastest，increasing by 89.78％ in 2013 and 142.81％ in 2014，compared with the year before；those of other drugs had negative growth rate. DDDs of Morphine hydrochloride sustained-release tablets were the highest among all the narcotics and first type psychotropic drugs and increased year by year，increasing from 26 848.00 in 2012 to 47 158.00 in 2014. CONCLUSIONS： The use of narcotic drugs and first type psychotropic drugs conform to the specifications，but they still need strict supervision to promote safe and effective use of them in the clinic.