OBJECTIVE： To provide reference for rational drug use in pediatric patients. METHODS： Drug use of pediatric patients in our hospital were analyzed retrospectively and statistically. 600 medical records and 3 000 outpatient prescriptions of pediatric patients were randomly selected from Jul. 2013 to Jul. 2014， to analyze the rationality of drug use. RESULTS： For pediatric inpatients， top one drug in the list of consumption sum was antibiotics （173 325.75 yuan）， among which Mezlocillin for injection took up the first place （37 771.1 yuan）； DDDs of Cefuroxime for injection was the highest （583.3）. Most of inpatients aged 3-6 years （42.83％）， and antibiotics mainly were used in form of single dose and two-drug combination （89.64％）. Irrational use of antibiotics in the inpatients mainly manifested as unreasonable usage and dosage （40.96％）. For outpatients， top one drug in the list of consumption sum was antibiotics （442 421.83 yuan）， among which most oral drug prescriptions contained cefuroxime axetil and cefdinir （90 pieces， accounting for 33.33％， respectively）， and most injection prescriptions involved cefuroxime （207 pieces， accounting for 19.13％）. Non-standardized outpatient prescriptions mainly manifested as non-standard specification and dosage writing （47.83％）. CONCLUSIONS： Irrational drug use still exist in our hospital. Clinical pharmacists should play a role on clinical drug use guidance and monitoring， strengthen prescription comment and improve the quality of drug use to ensure safe， rational and effective use of drugs in pediatric department.