OBJECTIVE：To provide reference for rational use of glucocorticoid in the clinic. METHODS：The glucocorticoid outpatient prescriptions collected from clinical departments of a hospital during Jan. 2013 to Jun. 2015 were analyzed statistically in respects of glucocorticoid use，department distribution，DDDs，distribution of prescription diagnosis，etc. RESULTS：Of 15 000 prescriptions，there were 1 562 glucocorticoid prescriptions，with utilization rate of 10.4％；189 prescriptions were recognized as irrational ones，with irrational rate of 12.1％. The proportion of glucocorticoid in otorhinolaryngology department was the highest（27.66％），and irrational drug use was the highest in pediatrics department（16.12％）；Dexamethasone injection was the most widely applied（44.88％）；most of glucocorticoid prescriptions were used for acute bronchitis and bronchitis（267 prescriptions）. CONCLUSIONS：The irrational glucocorticoid application has existed in the hospital，which deserved special attention. Hence，prescription check and evaluation should be strengthened to promote the safety and efficacy of glucocorticoid in clinical application.