浏览全部资源
扫码关注微信
1.陆军军医大学第二附属医院药学部,重庆 400037
2.重庆市妇幼保健院/重庆医科大学附属妇女儿童医院药学部,重庆 401147
Published:30 September 2022,
Received:24 January 2022,
Revised:29 July 2022,
扫 描 看 全 文
吴燕燕,王璨,杨昕炜等.临床药师参与1例椎间神经鞘瘤切除术后脓肿分枝杆菌感染的药学监护 Δ[J].中国药房,2022,33(18):2277-2280.
WU Yanyan,WANG Can,YANG Xinwei,et al.Participation of clinical pharmacists in pharmaceutical care for a patient with Mycobacterium abscess infection after the resection of intervertebral schwannoma[J].ZHONGGUO YAOFANG,2022,33(18):2277-2280.
吴燕燕,王璨,杨昕炜等.临床药师参与1例椎间神经鞘瘤切除术后脓肿分枝杆菌感染的药学监护 Δ[J].中国药房,2022,33(18):2277-2280. DOI: 10.6039/j.issn.1001-0408.2022.18.20.
WU Yanyan,WANG Can,YANG Xinwei,et al.Participation of clinical pharmacists in pharmaceutical care for a patient with Mycobacterium abscess infection after the resection of intervertebral schwannoma[J].ZHONGGUO YAOFANG,2022,33(18):2277-2280. DOI: 10.6039/j.issn.1001-0408.2022.18.20.
目的
2
为治疗脓肿分枝杆菌感染的药学监护提供思路。
方法
2
对临床药师参与的1例椎间神经鞘瘤切除术后脓肿分枝杆菌感染患者的诊疗方案进行分析。临床药师根据创口分泌物细菌培养及药敏试验结果,及时处理治疗过程中出现的药物不良反应,针对患者服用阿米卡星(0.4 g,静脉滴注,q12 h)后引起的耳鸣,建议停用阿米卡星,改为利奈唑胺,但该患者在服用利奈唑胺后出现膝关节痛,临床药师再次建议停用利奈唑胺,继续使用阿米卡星,并将剂量调整为0.8 g,静脉滴注,q24 h;同时对患者进行用药指导并嘱患者出院后定期复查随访。
结果
2
临床医师采纳了临床药师的建议,该患者未再出现耳鸣、膝关节痛等不适,肝肾功能也无异常。
结论
2
临床药师及时协助临床医师调整用药方案,提高了患者用药的有效性和安全性。
OBJECTIVE
2
To provide ideas for pharmaceutical care of
Mycobacterium abscess
infection.
METHODS
2
The diagnosis and treatment plan, about a patient with
M. abscess
infection after resection of intervertebral neurilemmoma participated by clinical pharmacists, was analyzed. According to the results of bacterial culture and drug sensitivity test of wound secretion, the clinical pharmacist timely dealed with the adverse drug reactions during the treatment. For the tinnitus caused by the patient taking amikacin (0.4 g, intravenous drip, q12 h), it was suggested to stop amikacin and replace it with linezolid; however, the patient suffered from knee pain after taking linezolid. The clinical pharmacist once again suggested stopping linezolid, continuing to use amikacin, and adjusting the dose to 0.8 g, intravenous drip, q24 h; at the same time, the patients were given medication guidance and ordered to have regular follow-up after discharge.
RESULTS
2
The physicians adopted the suggestions of clinical pharmacists, and the patient did not suffer from tinnitus, knee pain and other discomfort, and the liver and kidney functions were normal.
CONCLUSIONS
2
Clinical pharmacists timely assist clinicians to adjust the medication plan, which improves the effectiveness and safety of patients’ medication.
临床药师脓肿分枝杆菌皮肤软组织感染不良反应药学监护
clinical pharmacistMycobacterium abscessskinsoft tissueinfectionADRpharmaceutical care
DALEY C L,IACCARINO J M,LANGE C,et al. Treatment of nontuberculous mycobacterial pulmonary disease:an official ATS/ERS/ESCMID/IDSA clinical practice guideline[J]. Clin Infect Dis,2020,71(4):905-913.
中华医学会结核病学分会.非结核分枝杆菌病诊断与治疗指南:2020年版[J].中华结核和呼吸杂志,2020,43(11):918-946.
郑飞跃,吴燕,饶跃峰,等. 诺氏评估量表在药物不良反应评价中的作用及实例分析[J]. 中国药学杂志,2012,47(8):650-652.
范燕. 65例阿米卡星注射剂不良反应的文献分析[J].中国药物警戒,2013,10(12):740-743.
STEVENS D L,BISNO A L,CHAMBERS H F,et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections:2014 update by the In- fectious Diseases Society of America[J]. Clin Infect Dis,2014,59(2):e10-e52.
初乃惠,周文强,沙巍. 非结核分枝杆菌病治疗药品超说明书用法专家共识[J]. 中国防痨杂志,2020,42(8):769-787.
中国医药教育协会感染疾病专业委员会. 抗菌药物药代动力学/药效学理论临床应用专家共识[J]. 中华结核和呼吸杂志,2018,41(6):409-446.
邓阳,肖亦莎,李昕,等.氨基糖苷类抗生素治疗药物监测及其毒理机制研究进展[J].中国药理学与毒理学杂志,2019,33(12):1085-1092.
BARLAM T F,COSGROVE S E,ABBO L M,et al. Implementing an antibiotic stewardship program:guidelines by the infectious diseases society of America and the society for healthcare epidemiology of America[J]. Clin Infect Dis,2016,62(10):e51-e77.
ABDUL-AZIZ M H,ALFFENAAR J C,BASSETTI M,et al. Antimicrobial therapeutic drug monitoring in critically ill adult patients:a position paper[J]. Intensive Care Med,2020,46(6):1127-1153.
国家药监局.国家药监局关于修订阿米卡星注射剂说明书的公告:2021年第46号[EB/OL].(2021-04-06)[2022-07-29].https://www.nmpa.gov.cn/xxgk/ggtg/ypshmshxdgg/2021-0406150152190.htmlhttps://www.nmpa.gov.cn/xxgk/ggtg/ypshmshxdgg/2021-0406150152190.html.
RYBAK M J,ABATE B J,KANG S L,et al. Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity[J]. Antimicrob Agents Chemother,1999,43(7):1549-1555.
万丽,赵晴,陈军,等. 疼痛评估量表应用的中国专家共识:2020版[J]. 中华疼痛学杂志,2020(3):177-187.
范利华,陶惠华,马娟,等. 利奈唑胺有关物质的合成及其结构确证[J]. 精细化工中间体,2020,50(5):41-43,56.
AGYEMAN A A,OFORI-ASENSO R. Efficacy and safety profile of linezolid in the treatment of multidrug-resistant(MDR)and extensively drug-resistant(XDR) tuberculosis:a systematic review and meta-analysis[J]. Ann Clin Microbiol Antimicrob,2016,15(1):41.
LEE M,LEE J,CARROLL M W,et al. Linezolid for treatment of chronic extensively drug-resistant tuberculosis[J]. N Engl J Med,2012,367(16):1508-1518.
VALENT P,KLION A D,HORNY H P,et al. Contem-porary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes[J]. J Allergy Clin Immunol,2012,130(3):607-612.
YASUI-FURUKORI N,SATO Y,KATO H,et al. Paroxetine-associated hypereosinophilia may clinically resemble a panic attack[J]. Clin Neuropharmacol,2012,35(1):47-48.
0
Views
4
下载量
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution