Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A

HU Jinwei; ZHU Huaijun; LAO Qianying; LI Danying

doi:10.6039/j.issn.1001-0408.2022.18.22

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Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A

更新时间：2023-02-22

- Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A
- ZHONGGUO YAOFANG Vol. 33, Issue 18, Pages: 2285-2289(2022)
- 作者机构：
  
  1.南京大学医学院附属鼓楼医院药学部，南京　210008
  2.南京中医药大学中西医结合鼓楼临床医学院，南京　210008
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2022.18.22
  CLC： R969
- Published：30 September 2022，
  
  Received：25 February 2022，
  
  Revised：17 August 2022，
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胡锦炜,朱怀军,劳茜莹等.环孢素A个体化用药临床预后的实验室检查指标研究进展 ^Δ[J].中国药房,2022,33(18):2285-2289.

HU Jinwei,ZHU Huaijun,LAO Qianying,et al.Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A[J].ZHONGGUO YAOFANG,2022,33(18):2285-2289.
胡锦炜,朱怀军,劳茜莹等.环孢素A个体化用药临床预后的实验室检查指标研究进展 ^Δ[J].中国药房,2022,33(18):2285-2289. DOI： 10.6039/j.issn.1001-0408.2022.18.22.

HU Jinwei,ZHU Huaijun,LAO Qianying,et al.Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A[J].ZHONGGUO YAOFANG,2022,33(18):2285-2289. DOI： 10.6039/j.issn.1001-0408.2022.18.22.

摘要

环孢素A在器官移植以及自身免疫疾病治疗中应用广泛，由于该药存在明显的个体间代谢差异，临床使用时需要根据患者血药浓度调整给药剂量。但环孢素A的血药浓度并不能准确反映其临床预后。本文围绕外周血单个核细胞内环孢素A浓度、钙调磷酸酶活性和T细胞功能以及环孢素A代谢物浓度4个实验室检查指标，综述其与环孢素A药动学以及临床预后的相关性。结果发现以上指标对患者使用环孢素A的临床预后情况有一定的预示作用，可弥补血药浓度监测的不足，但其临床实用性还需进一步提高。

Abstract

Cyclosporine A is widely used in organ transplantation and autoimmune diseases. Due to the obvious differences in metabolism between individuals， the dosage should be adjusted according to the patient’s blood concentration during clinical use. But the blood concentration does not reflect accurately its clinical prognosis. This article focuses on the four laboratory examination indexes following aspects： the cyclosporine A concentration of peripheral blood mononuclear cells， calcineurin activity， T cell function and metabolite concentration of cyclosporine A. The relationship between them and the pharmacokinetics of cyclosporine and clinical prognosis were reviewed. It’s found that the above indicators have a certain predictive effect on the clinical prognosis of patients receiving cyclosporine A， which can make up for the insufficiency of blood drug concentration monitoring， and the clinical practicability needs to be further improved.

关键词

环孢素A治疗药物监测临床疗效安全性实验室检查指标

Keywords

therapeutic drug monitoringclinical efficacysafetylaboratory examination index

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