Investigation of the prescriptions of outpatient/emergency oral iron supplements in 8 children’s/maternity and children’s hospitals of third-grade class A

LI Rongrong; LIU Qian; WANG Tingyu; SUN Yanyan

doi:10.6039/j.issn.1001-0408.2022.23.03

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Investigation of the prescriptions of outpatient/emergency oral iron supplements in 8 children’s/maternity and children’s hospitals of third-grade class A

更新时间：2023-02-22

- Investigation of the prescriptions of outpatient/emergency oral iron supplements in 8 children’s/maternity and children’s hospitals of third-grade class A
- ZHONGGUO YAOFANG Vol. 33, Issue 23, Pages: 2831-2834(2022)
- 作者机构：
  
  天津市儿童医院/天津大学儿童医院药剂科，天津　300134
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2022.23.03
  CLC： R952
- Published：15 December 2022，
  
  Received：08 June 2022，
  
  Revised：21 October 2022，
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李荣荣,刘倩,王婷谕等.8家“三甲”儿童/妇幼医院门急诊口服铁剂处方调研 ^Δ[J].中国药房,2022,33(23):2831-2834.

LI Rongrong,LIU Qian,WANG Tingyu,et al.Investigation of the prescriptions of outpatient/emergency oral iron supplements in 8 children’s/maternity and children’s hospitals of third-grade class A[J].ZHONGGUO YAOFANG,2022,33(23):2831-2834.
李荣荣,刘倩,王婷谕等.8家“三甲”儿童/妇幼医院门急诊口服铁剂处方调研 ^Δ[J].中国药房,2022,33(23):2831-2834. DOI： 10.6039/j.issn.1001-0408.2022.23.03.

LI Rongrong,LIU Qian,WANG Tingyu,et al.Investigation of the prescriptions of outpatient/emergency oral iron supplements in 8 children’s/maternity and children’s hospitals of third-grade class A[J].ZHONGGUO YAOFANG,2022,33(23):2831-2834. DOI： 10.6039/j.issn.1001-0408.2022.23.03.

摘要

目的

了解我国儿科临床口服铁剂的应用现状及存在的问题，为儿童口服铁剂的合理应用提供参考。

方法

通过调研全国六大行政区域内8家“三甲”儿童/妇幼医院2021年1－6月含口服铁剂的全部门急诊处方（儿童患者），对处方中涉及的患儿基本信息、口服铁剂品种、联合用药情况、临床诊断、超说明书用药情况等进行统计分析。

结果

本研究共调研门急诊处方20 988张，涉及12种口服铁剂。其中，第3代口服铁剂处方数（14 038张，占66.89%）最多，剂型以口服溶液剂为主；年龄范围在1～＜3岁患儿的处方数（8 532张，占40.65%）最多；处方中与口服铁剂联用的药物多为维生素类（5 577张，占26.57%）；临床诊断为铁缺乏/缺铁性贫血以外其他疾病或症状的处方超过一半（11 210张，占53.41%）；超说明书用药处方共13 615张（占64.87%），主要为超适应证用药（10 923张，占52.04%）和超用法用量用药（6 393张，占30.46%）；禁忌证用药处方共163张（占0.78%）。

结论

我国“三甲”儿童/妇幼医院儿科临床中口服铁剂品种和剂型的选择较为合理，但超说明书用药问题仍有待解决。相关部门和各医疗机构应予以重视并采取措施共同促进口服铁剂在儿科临床合理应用。

Abstract

OBJECTIVE

To investigate clinical situation and problems of oral iron supplements in pediatrics department of China， and to provide reference for rational application of oral iron supplements in children.

METHODS

Through surveying the prescriptions of outpatient/emergency oral iron supplements （pediatric patients） in 8 children’s/maternity and children’s hospitals of third-grade class A from six administrative regions of China， the information of the prescriptions was analyzed statistically in terms of general information of children， the types of oral iron supplements， drug combination， clinical diagnosis， off-label drug use.

RESULTS

A total of 20 988 outpatient/emergency prescriptions were investigated， involving 12 kinds of oral iron supplements. Among them， the third generation of oral iron supplements ranked first（14 038 prescriptions，66.89%）， and the dosage form was mainly oral solution. Children aged 1-＜3 years old accounted for the largest proportion（8 532 prescriptions，40.65%）. Most of the drugs prescribed in combination with oral iron supplements were vitamins（5 577 prescriptions，26.57%）. More than half of the prescriptions（11 210 prescriptions，53.41%）　were for diseases or symptoms other than iron deficiency/iron deficiency anemia. There were a total of 13 615 prescriptions（64.87%） of off-label drug use， mainly manifesting as super-indications （10 923 prescriptions，52.04%） and super-usage and dosage（6 393 prescriptions，30.46%）. There were 163 prescriptions beyond contraindications （0.78%）.

CONCLUSIONS

The varieties and dosage forms of oral iron supplements in pediatrics are comparatively reasonable in children’s/maternity and children’s hospitals of third-grade class A in China，but the problem of off-label drug use still needs to be solved. The relevant departments and medical institutions should pay attention and take measures to promote the rational use of oral iron supplements in pediatrics.

关键词

口服铁剂儿童超说明书用药处方分析

Keywords

childrenoff-label drug useprescription analysis

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