Study on improvement effects of Citri Grandis Exocarpium extract on anorexia in immature rats

LIU Jia; WU Daoshun; PAN Yunfeng; WANG Yanhui; LUO Yun; SUN Xiaobo

doi:10.6039/j.issn.1001-0408.2022.23.22

您当前的位置：

首页 >

文章列表页 >

Study on improvement effects of Citri Grandis Exocarpium extract on anorexia in immature rats

更新时间：2023-02-22

- Study on improvement effects of Citri Grandis Exocarpium extract on anorexia in immature rats
- ZHONGGUO YAOFANG Vol. 33, Issue 23, Pages: 2931-2935(2022)
- 作者机构：
  
  1.中国医学科学院药用植物研究所，北京　100193
  2.贵州中医药大学药学院，贵阳　550025
  3.广州市香雪制药股份有限公司，广州　510663
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2022.23.22
  CLC： R965
- Published：15 December 2022，
  
  Received：12 June 2022，
  
  Revised：07 September 2022，
扫描看全文
刘佳,吴道顺,潘云风等.化橘红提取物对幼龄大鼠厌食症的改善作用研究 ^Δ[J].中国药房,2022,33(23):2931-2935.

LIU Jia,WU Daoshun,PAN Yunfeng,et al.Study on improvement effects of Citri Grandis Exocarpium extract on anorexia in immature rats[J].ZHONGGUO YAOFANG,2022,33(23):2931-2935.
刘佳,吴道顺,潘云风等.化橘红提取物对幼龄大鼠厌食症的改善作用研究 ^Δ[J].中国药房,2022,33(23):2931-2935. DOI： 10.6039/j.issn.1001-0408.2022.23.22.

LIU Jia,WU Daoshun,PAN Yunfeng,et al.Study on improvement effects of Citri Grandis Exocarpium extract on anorexia in immature rats[J].ZHONGGUO YAOFANG,2022,33(23):2931-2935. DOI： 10.6039/j.issn.1001-0408.2022.23.22.

摘要

目的

探究化橘红提取物对厌食症模型幼龄大鼠的药效学作用。

方法

随机选取10只幼龄大鼠作为对照组给予常规饲料，其余50只幼龄大鼠采用病因模拟法建立厌食症模型，将造模成功的幼龄大鼠分成模型组、健胃消食片组（0.65 g/kg）和化橘红提取物低剂量（0.5 g/kg）、中剂量（1.0 g/kg）、高剂量（2.0 g/kg）组。连续灌胃给药14 d后，观察各组大鼠体质量及摄食量变化，检测胃酸浓度、胃蛋白酶活性，以及血清中胃泌素（GAS）、胃动素（MTL）、抑胃肽（GIP）水平，观察胃组织病理变化情况。

结果

与对照组比较，模型组幼龄大鼠摄食量、胃酸浓度、胃蛋白酶活性、GAS、MTL水平显著下降，GIP水平显著升高（

＜0.05）；胃组织病理学检查出现明显胃黏膜充血、上皮细胞松解脱落现象。与模型组比较，各给药组经药物干预后，上述指标均有不同程度的改善，胃组织病理损伤减轻。

结论

化橘红提取物通过调节胃酸浓度、胃蛋白酶活性、GAS、MTL、GIP水平，改善胃动力，保护胃黏膜，从而改善幼龄大鼠的厌食症。

Abstract

OBJECTIVE

To investigate the pharmacodynamic effects of the Citri Grandis Exocarpium extract on anorexia model immature rats.

METHODS

Ten immature rats were randomly selected as the control group and given regular diet， while anorexia model was induced in the remaining 50 immature rats using the etiological simulation method. The immature model rats were divided into the model group， Jianwei xiaoshi tablet group （0.65 g/kg）， Citri Grandis Exocarpium extract low-dose， medium-dose and high-dose groups （0.5， 1.0， 2.0 g/kg）. After 14 d of continuous intragastric administration， the body mass and food intake of rats in each group were observed， and the gastric acid concentration， pepsinase activity， serum levels of gastrin （GAS）， motilin （MTL） and gastric inhibitory peptide （GIP） were measured.The histopathological changes in the gastric tissue were observed.

RESULTS

Compared with control group， the food intake， gastric acid concentration， pepsin activity， the levels of GAS and MTL were significantly decreased and GIP level was significantly increased in the immature rats of model group （

＜0.05）； gastric histopathological examination showed significant gastric mucosal congestion and loosening and detachment of epithelial cells. Compared with model group， all administration groups showed different degrees of improvement in the above indexes and decreased gastric histopathological damage after drug intervention.

CONCLUSIONS

Citri Grandis Exocarpium extract improves gastric motility and protects gastric mucosa in the immature rats by regulating the concentration of gastric acid， pepsin activity， the levels of GAS， MTL and GIP， thus improving anorexia in immature rats.

关键词

化橘红提取物厌食症胃蛋白酶胃泌素胃动素抑胃肽

Keywords

anorexiapepasegastrinmotilingastric inhibitory peptide

references

LUCARELLI L，CIMINO S，D’OLIMPIO F，et al. Fee- ding disorders of early childhood：an empirical study of diagnostic subtypes[J]. Int J Eat Disord，2013，46（2）：147-155.

MAIRS R，NICHOLLS D. Assessment and treatment of eating disorders in children and adolescents[J]. Arch Dis Child，2016，101（12）：1168-1175.

吕彩兰，杨楠，陈静，等.苍术-白术药对治疗小儿厌食症的机制研究[J].中医药临床杂志，2022，34（1）：76-81.

邹庆，李建保，田金娜.从“通、补、和”三法论治小儿厌食症[J].亚太传统医药，2021，17（10）：117-119.

国家药典委员会.中华人民共和国药典：一部[S]. 2020年版.北京：中国医药科技出版社，2020：76.

JIANG K，SONG Q，WANG L，et al. Antitussive，expectorant and anti-inflammatory activities of different extracts from Exocarpium Citri Grandis[J]. J Ethnopharmacol，2014，156：97-101.

ZHU Z T，WU H，SU W W，et al. Effects of total flavonoids from Exocarpium Citri Grandis on air pollution particle-induced pulmonary inflammation and oxidative stress in mice[J]. J Food Sci，2019，84（12）：3843-3849.

KONG F S，DING Z D，ZHANG K，et al. Optimization of extraction flavonoids from Exocarpium Citri Grandis and evaluation its hypoglycemic and hypolipidemic activities[J]. J Ethnopharmacol，2020，262：113178.

钟楚楚，吴孟华，余品皓，等.橘红与化橘红采制、炮制及功效的古今演变探析[J].中国中药杂志，2021，46（18）：4865-4874.

太平惠民和剂局.太平惠民和剂局方[M].北京：中国中医药出版社，1996：62-100.

王瑜真，陈立文，张丽娟.橘皮、橘红及化橘红演变的古籍考证[J].实用医药杂志，2014，31（9）：823-824.

吴孟华，钟楚楚，余品皓，等.橘红与化橘红的古今演变探析[J].中国中药杂志，2021，46（3）：736-744.

宋小仙，涂如霞，兰波，等.鸡矢藤提取物对幼龄厌食症模型大鼠的影响[J].中药药理与临床，2021，37（6）：63-66.

李玉霞，史正刚，吴丽萍，等.运脾消积法治疗厌食症幼龄大鼠的代谢组学[J].中成药，2021，43（1）：73-80.

李虹，齐薛浩，张含花.复方消化酶胶囊治疗厌食症患儿的疗效及对血清瘦素及血浆胆囊收缩素水平的影响[J].临床和实验医学杂志，2021，20（21）：2324-2327.

SCHUBERT M L，REHFELD J F. Gastric peptides-gastrin and somatostatin[J]. Compr Physiol，2019，10（1）：197-228.

DELOOSE E，VERBEURE W，DEPOORTERE I，et al. Motilin：from gastric motility stimulation to hunger signalling[J]. Nat Rev Endocrinol，2019，15（4）：238-250.

DELOOSE E，VOS R，JANSSEN P，et al. The motilin receptor agonist erythromycin stimulates hunger and food intake through a cholinergic pathway[J]. Am J Clin Nutr，2016，103（3）：730-737.

TACK J，DELOOSE E，ANG D，et al. Motilin-induced gastric contractions signal hunger in man[J]. Gut，2016，65（2）：214-224.

PEDERSON R A，MCINTOSH C H. Discovery of gastric inhibitory polypeptide and its subsequent fate：personal reflections[J]. J Diabetes Investig，2016，7（Suppl 1）：4-7.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Zingiber officinale and processed Zingiber officinale on pharmacodynamic indexes and intestinal flora on gastric ulcer rats with spleen-stomach deficiency and cold type

Related Author

YU Lingying

LI Xing

CAI Pingjun

QIANG Mengqin

DONG Baohua

JIANG Yunxiu

HUANG Qinwan

CHEN Zhimin

Related Institution

College of Pharmacy， Chengdu University of Traditional Chinese Medicine/State Key Laboratory of Southwestern Chinese Medicine Resources

Address：8/F,129 Daping Main Street,Yuzhong District,Chongqing 400042,P.R.China
Technical support is provided by Beijing Founder Electronics co., LTD 渝ICP备15012710号公网安备50010302001817
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰