Investigation on anti-tumor mechanism of tea polyphenol and epigallocatechin gallate based on immunity regulation

LI Guangda; WANG Jing; XU Jing; XIE Meiwen; ZHOU Yibin; HOU Li

doi:10.6039/j.issn.1001-0408.2022.24.25

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Investigation on anti-tumor mechanism of tea polyphenol and epigallocatechin gallate based on immunity regulation

更新时间：2023-02-22

- Investigation on anti-tumor mechanism of tea polyphenol and epigallocatechin gallate based on immunity regulation
- ZHONGGUO YAOFANG Vol. 33, Issue 24, Pages: 3067-3072(2022)
- 作者机构：
  
  北京中医药大学东直门医院血液肿瘤科，北京　100700
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2022.24.25
  CLC： R96
- Published：30 December 2022，
  
  Received：18 July 2022，
  
  Revised：24 November 2022，
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李光达,王婧,许晶等.基于免疫调节探讨茶多酚及表没食子儿茶素没食子酸酯的抗肿瘤机制^Δ[J].中国药房,2022,33(24):3067-3072.

LI Guangda,WANG Jing,XU Jing,et al.Investigation on anti-tumor mechanism of tea polyphenol and epigallocatechin gallate based on immunity regulation[J].ZHONGGUO YAOFANG,2022,33(24):3067-3072.
李光达,王婧,许晶等.基于免疫调节探讨茶多酚及表没食子儿茶素没食子酸酯的抗肿瘤机制^Δ[J].中国药房,2022,33(24):3067-3072. DOI： 10.6039/j.issn.1001-0408.2022.24.25.

LI Guangda,WANG Jing,XU Jing,et al.Investigation on anti-tumor mechanism of tea polyphenol and epigallocatechin gallate based on immunity regulation[J].ZHONGGUO YAOFANG,2022,33(24):3067-3072. DOI： 10.6039/j.issn.1001-0408.2022.24.25.

摘要

茶多酚是茶叶的主要活性物质之一，表没食子儿茶素没食子酸酯（EGCG）则是茶多酚发挥生物作用的主要活性成分。二者作为免疫调节剂可用于肿瘤的治疗。本文从提高免疫效应、改善免疫逃逸两个方面综述茶多酚及EGCG的抗肿瘤作用机制。结果发现，茶多酚及EGCG不仅可以通过活化免疫细胞与促进细胞因子分泌来提高抗肿瘤免疫效应，还可通过调节免疫抑制细胞、调控免疫检查点、调节细胞因子、抑制免疫调节酶与Janus激酶/信号转导和转录激活子（JAK/STAT）通路来改善肿瘤免疫逃逸，在肿瘤免疫治疗方面具有较大潜力。

Abstract

Tea polyphenol （TP） is the main active constituent in tea， and epigallocatechin gallate （EGCG） is the main active constituent of TP that plays a biological role. Both of them can be used as immunomodulators in the treatment of tumor. In this paper， the anti-tumor mechanism of TP and EGCG was summarized from two aspects： enhancing immune effect and improving immune escape. The results showed that TP and EGCG could not only enhance the anti-tumor immune effect by promoting the activity of immune cells and the secretion of cytokines， but also improve tumor immune escape by regulating immunosuppressive cells， immune checkpoints， cytokines， immunomodulatory enzymes and JAK/STAT pathway， which has great potential in tumor immunotherapy.

关键词

茶多酚表没食子儿茶素没食子酸酯免疫调节免疫效应免疫逃逸抗肿瘤机制

Keywords

epigallocatechin gallateimmunoregulationimmune effectimmune escapeantitumormechanism

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