Research progress on the effect mechanism of polysaccharides against pancreatic cancer

LIU Guangyu; WANG Qi; SU Ling

doi:10.6039/j.issn.1001-0408.2023.01.22

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Research progress on the effect mechanism of polysaccharides against pancreatic cancer

更新时间：2023-02-22

- Research progress on the effect mechanism of polysaccharides against pancreatic cancer
- ZHONGGUO YAOFANG Vol. 34, Issue 1, Pages: 111-116(2023)
- 作者机构：
  
  1.吉林农业大学食药用菌教育部工程研究中心，长春　130118
  2.吉林农业大学中药材学院，长春　130118
  3.吉林农业大学植物保护学院，长春　130118
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.01.22
  CLC： R965;O629.12
- Published：15 January 2023，
  
  Received：29 June 2022，
  
  Revised：16 December 2022，
扫描看全文
刘光宇,王琦,苏玲.多糖类成分抗胰腺癌作用机制的研究进展 ^Δ[J].中国药房,2023,34(01):111-116.

LIU Guangyu,WANG Qi,SU Ling.Research progress on the effect mechanism of polysaccharides against pancreatic cancer[J].ZHONGGUO YAOFANG,2023,34(01):111-116.
刘光宇,王琦,苏玲.多糖类成分抗胰腺癌作用机制的研究进展 ^Δ[J].中国药房,2023,34(01):111-116. DOI： 10.6039/j.issn.1001-0408.2023.01.22.

LIU Guangyu,WANG Qi,SU Ling.Research progress on the effect mechanism of polysaccharides against pancreatic cancer[J].ZHONGGUO YAOFANG,2023,34(01):111-116. DOI： 10.6039/j.issn.1001-0408.2023.01.22.

摘要

多糖是公认的免疫调节剂，已被证实对多种癌细胞具有抑制作用，具有开发为抗癌药物的潜力。胰腺癌作为病死率最高的癌症之一，长期采用化疗药物治疗，易产生免疫缺陷、疲劳、神经系统病变等多种副作用。本文总结了国内外多糖类成分抗胰腺癌的研究现状，梳理出多糖类成分可以通过多靶点的作用方式，调控核因子κB、Hippo-转录共激活因子相关蛋白、整合素等相关信号通路，诱导癌细胞凋亡、自噬，抑制癌细胞增殖、迁移与侵袭，调控癌细胞周期，从而发挥抗胰腺癌的作用。

Abstract

Polysaccharide is a recognized immunomodulator that has been shown to have inhibitory effects on a variety of cancer cells and has the potential to be developed as an anti-cancer drug. Pancreatic cancer， one of the cancers with the highest mortality rate， is treated with long-term chemotherapeutic drugs and is prone to a variety of side effects such as immune deficiency， fatigue， and neurological lesions. The polysaccharide anti-pancreatic cancer research landscape both domestically and internationally is summarized in this publication. By regulating nuclear factor-κB， Hippo-Yes-associated protein， integrin and other signaling pathways， polysaccharide components play an anti-pancreatic cancer role by multi-target ways， such as inducing apoptosis and autophagy， inhibiting proliferation， migration and invasion of cancer cells， and regulating the cancer cell cycle.

关键词

多糖胰腺癌作用机制

Keywords

pancreatic cancereffect mechanism

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