Comprehensive quality evaluation of <italic style="font-style: italic">Periploca forrestii </italic>produced in Guizhou using multi-index components combined with multivariate statistical analysis

ZENG Lingqin; HE Kang; GUO Jiangtao; LIU Jie; ZHANG Yongping; SUN Yichun; LI Huixin

doi:10.6039/j.issn.1001-0408.2023.07.07

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Comprehensive quality evaluation of Periploca forrestii produced in Guizhou using multi-index components combined with multivariate statistical analysis

更新时间：2024-02-19

- Comprehensive quality evaluation of Periploca forrestii produced in Guizhou using multi-index components combined with multivariate statistical analysis
- ZHONGGUO YAOFANG Vol. 34, Issue 7, Pages: 802-806(2023)
- 作者机构：
  
  1.贵州中医药大学药学院，贵阳;550025
  2.国药集团（贵州）同济堂制药有限公司，贵阳　550009
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.07.07
  CLC： R917
- Published：15 April 2023，
  
  Received：29 September 2022，
  
  Revised：26 February 2023，
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曾令琴,何康,郭江涛等.多指标成分结合多元统计分析法综合评价黔产黑骨藤质量 ^Δ[J].中国药房,2023,34(07):802-806.

ZENG Lingqin,HE Kang,GUO Jiangtao,et al.Comprehensive quality evaluation of Periploca forrestii produced in Guizhou using multi-index components combined with multivariate statistical analysis[J].ZHONGGUO YAOFANG,2023,34(07):802-806.
曾令琴,何康,郭江涛等.多指标成分结合多元统计分析法综合评价黔产黑骨藤质量 ^Δ[J].中国药房,2023,34(07):802-806. DOI： 10.6039/j.issn.1001-0408.2023.07.07.

ZENG Lingqin,HE Kang,GUO Jiangtao,et al.Comprehensive quality evaluation of Periploca forrestii produced in Guizhou using multi-index components combined with multivariate statistical analysis[J].ZHONGGUO YAOFANG,2023,34(07):802-806. DOI： 10.6039/j.issn.1001-0408.2023.07.07.

摘要

目的

建立多指标成分结合多元统计分析的综合质量评价方法，综合评价黑骨藤药材的质量。

方法

以贵州不同产地的11批黑骨藤药材为样品，采用高效液相色谱法测定其中新绿原酸、隐绿原酸、绿原酸、原花青素A2、异绿原酸A、异绿原酸C的含量，并采用聚类热图分析、灰色关联度分析（GRA）和熵权逼近理想解排序（TOPSIS）法综合评价其质量。

结果

含量测定的方法学考察结果均符合相关规定，各待测成分在各自进样量范围内线性关系和准确度均良好。11批样品中绿原酸、隐绿原酸、新绿原酸、原花青素A2、异绿原酸A、异绿原酸C的含量分别为3.650～7.302、0.888～2.575、1.371～2.386、0.947～1.469、0.084～0.169、0.725～1.067 mg/g；各成分含量差异显著，其中以绿原酸含量最高，异绿原酸A最低。综合聚类热图、GRA和TOPSIS分析结果显示，样品S5和S10的综合质量相对较好。

结论

所建立的含量测定方法准确、稳定、简便，结合多元统计分析方法，可用于黑骨藤药材的质量评价。在11批不同产地样品中，以贵州省安顺市西秀区旧州镇和蔡官镇所产样品的质量相对较好。

Abstract

OBJECTIVE

To establish comprehensive quality evaluation method based on multi-index components combined with multivariate statistical analysis， and to comprehensively evaluate the quality of

Periploca forrestii.

METHODS

Taking 11 batches of

P. forrestii

medicinal materials from different areas in Guizhou as samples， the contents of neochlorogenic acid， cryptochlorogenic acid， chlorogenic acid， procyanidin A2， isochlorogenic acid A and isochlorogenic acid C were determined by HPLC. Clustering heat map analysis， grey correlation analysis（GRA） and technique for order preference by similarity to ideal solution（TOPSIS） were used to evaluate the quality of

P. forrestii.

RESULTS

The results of methodological investigation of content determination were in accordance with the relevant regulations， and the linear relationship and accuracy of each component were good in their respective sampling range. The contents of chlorogenic acid， cryptochlorogenic acid， neochlorogenic acid， procyanidin A2， isochlorogenic acid A and isochlorogenic acid C in 11 batches of samples were 3.650-7.302， 0.888-2.575， 1.371-2.386， 0.947-1.469， 0.084-0.169 and 0.725-1.067 mg/g， respectively. The content of each component was significantly different， with the highest content of chlorogenic acid and the lowest content of isochlorogenic acid A. The comprehensive results of cluster heat map， GRA and TOPSIS analysis showed that the comprehensive quality of S5 and S10 was relatively good.

CONCLUSIONS

The established method is accurate， stable and simple. Combined with multivariate statistical analysis method， it can be used for quality evaluation of

P. forrestii

. The quality of samples from Jiuzhou Town and Caiguan Town of Xixiu District in Anshun City of Guizhou Province are relatively good among 11 different origin samples.

关键词

黑骨藤含量测定多指标成分多元统计分析质量评价

Keywords

content determinationmulti-index componentmultivariate statistical analysisquality evaluation

references

贵州省药品监督管理局.贵州省中药材、民族药材质量标准：2003年版[M].贵阳：贵州科技出版社，2003：381.

CHEN L，LI J S，KE X，et al. The therapeutic effects of Periploca forrestii Schltr. stem extracts on collagen-induced arthritis by inhibiting the activation of Src/NF-κB signaling pathway in rats[J]. J Ethnopharmacol，2017，202：12-19.

CHEN L，LI J S，KE X，et al. Chemical profiling and the potential active constituents responsible for wound healing in Periploca forrestii Schltr[J]. J Ethnopharmacol，2018，224：230-241.

吕苏珊.基于生物酶技术的黑骨藤皂苷类成分提取工艺及抗炎活性评价研究[D].贵阳：贵州师范大学，2016.

余玺，陈晨.黑骨藤化学成分的研究[J].中成药，2022，44（6）：1845-1849.

CHEN L，TANG S Q，LI X J，et al. A review on traditional usages，chemical constituents and pharmacological activities of Periploca forrestii Schltr[J]. J Ethnopharmacol，2021，271：113892.

古金华，吴娅琳，赵平.黑骨藤追风活络胶囊联合甲氨蝶呤治疗类风湿关节炎的临床分析[J]. 中国医药指南，2018，16（20）：219-220.

王霞，杨健，宋菲，等.苗药黑骨藤中咖啡酰基奎宁酸类部位对人类风湿性关节炎成纤维样滑膜细胞MH7A增殖及炎症因子分泌的影响[J].中国药房，2017，28（28）：3949-3952.

HAO S，XIAO Y，LIN Y，et al. Chlorogenic acid-enriched extract from Eucommia ulmoides leaves inhibits hepatic lipid accumulation through regulation of cholesterol metabolism in HepG2 cells[J]. Pharm Biol，2016，54（2）：251-259.

黄婷，周璐，梅婵，等.枸杞中原花青素和总黄酮的抗氧化活性研究[J].生物化工，2020，6（1）：72-75.

林方芬，黄曦，黄笑夏.灰色关联分析评价不同产地金果榄质量[J].中国药师，2021，24（10）：1942-1945.

石依姗，万青，汪秋兰，等.基于熵权TOPSIS法和灰色关联度分析的藤茶药材等级研究[J].中草药，2022，53（17）：5504-5512.

安兰兰，李开敏，何倩倩，等.基于6种咖啡酰基奎宁酸类成分结合化学计量法评价不同产地苗药黑骨藤的质量[J].中草药，2020，51（22）：5850-5855.

王霞，蒋礼，何燕玲，等.黑骨藤中咖啡酰基奎宁酸类化合物体外抗类风湿性关节炎机制研究[J].中国药理学通报，2018，34（10）：1362-1367.

杨光美.原花青素A2肠道菌群代谢物抑制肝细胞脂肪变性作用及机制研究[D].海口：海南大学，2017.

杨正明，威则日沙，李学学，等.基于多元统计分析的川产道地药材江油附子和川乌中6种生物碱含量比较研究[J].中草药，2019，50（6）：1461-1471.

李硕，王文全，侯俊玲，等.基于灰色关联度法评价商品防风药材质量[J].北京中医药大学学报，2015，38（4）：247-252.

吴红伟，李东辉，张育贵，等.基于熵权TOPSIS模型对不同加工方式黄芪药材质量的综合评价[J].中国药学杂志，2021，56（16）：1325-1331.

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Comprehensive quality evaluation of Periploca forrestii produced in Guizhou using multi-index components combined with multivariate statistical analysis

DOI：10.6039/j.issn.1001-0408.2023.07.07

摘要

Abstract

关键词

Keywords

references