Research progress of exosome drug loading system

WEN Wulong; ZHANG Weiye; ZHANG Junhao; LIANG Xiao; XIAO Zhan; SUN Xin; YANG Jing; WANG Rui

doi:10.6039/j.issn.1001-0408.2023.10.23

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Research progress of exosome drug loading system

更新时间：2023-05-25

- Research progress of exosome drug loading system
- ZHONGGUO YAOFANG Vol. 34, Issue 10, Pages: 1271-1275(2023)
- 作者机构：
  
  1.黑龙江中医药大学药学院，哈尔滨　150040
  2.黑龙江中医药大学基础医学院，哈尔滨　150040
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.10.23
  CLC： R943
- Published：30 May 2023，
  
  Received：16 November 2022，
  
  Revised：23 April 2023，
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文武龙,张炜烨,张筠昊等.外泌体载药系统的研究进展 ^Δ[J].中国药房,2023,34(10):1271-1275.

WEN Wulong,ZHANG Weiye,ZHANG Junhao,et al.Research progress of exosome drug loading system[J].ZHONGGUO YAOFANG,2023,34(10):1271-1275.
文武龙,张炜烨,张筠昊等.外泌体载药系统的研究进展 ^Δ[J].中国药房,2023,34(10):1271-1275. DOI： 10.6039/j.issn.1001-0408.2023.10.23.

WEN Wulong,ZHANG Weiye,ZHANG Junhao,et al.Research progress of exosome drug loading system[J].ZHONGGUO YAOFANG,2023,34(10):1271-1275. DOI： 10.6039/j.issn.1001-0408.2023.10.23.

摘要

外泌体是一种由多种细胞分泌且具有脂质双层膜结构的囊性小泡，其具有良好的生物相容性、高靶向性和高稳定性，是药物递送系统中具有极大发展潜力的天然纳米级药物载体。本文对外泌体及其特性、外泌体载药途径及方法、工程化外泌体载药系统靶向治疗疾病的设计策略及外泌体载药系统在多种疾病治疗中的应用现状进行综述。外泌体载药途径可分为外源性和内源性两大类，常用的外泌体载药方法包括电穿孔法、共孵育法、超声法等；工程化外泌体载药系统可以进一步提高载药量，增强药物的靶向性，主要通过基因工程技术、物理修饰法、化学修饰法等途径对外泌体进行表面修饰。外泌体载药系统为关节炎类、肿瘤类、脑部等疾病的靶向治疗提供了新思路。

Abstract

Exosome is a kind of vesicle secreted by a variety of cells with lipid bilayer membrane structure， which has good biocompatibility， high targeting and high stability， and is a natural nanoscale drug carrier with great development potential in drug delivery system. In this paper， exosomes and their properties， exosome drug delivery pathways and methods， the design strategy of engineered exosome drug delivery systems for targeted disease therapy， and the application of exosome drug delivery systems in the treatment of a variety of diseases were reviewed. Exosome drug delivery pathways could be divided into two categories： exogenous and endogenous. Common exosome drug delivery methods included electroporation， co-incubation， and ultrasound. Engineered exosome drug delivery system can further improve drug loading and enhance drug targeting. The main way of engineering is to modify exosome surface through genetic engineering technology， physical modification， chemical modification， etc. Exosome drug delivery system provides a new idea for targeted therapy of arthritis， tumor， brain and other diseases.

关键词

外泌体载药系统表面修饰靶向治疗

Keywords

drug loading systemsurface modificationtargeted therapy

references

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