Research progress about effective components of Astragali Radix in the intervention of diabetic retinopathy and its mechanism

LIU Ruicheng; KONG Ling; SUN Ye; WANG Xijun

doi:10.6039/j.issn.1001-0408.2023.11.23

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Research progress about effective components of Astragali Radix in the intervention of diabetic retinopathy and its mechanism

更新时间：2023-06-09

- Research progress about effective components of Astragali Radix in the intervention of diabetic retinopathy and its mechanism
- ZHONGGUO YAOFANG Vol. 34, Issue 11, Pages: 1404-1408(2023)
- 作者机构：
  
  1.黑龙江中医药大学国家中医药管理局中医方证代谢组学研究中心/国家中医药管理局中药血清药物化学重点研究室/中药材GAP研究中心，哈尔滨　150040
  2.广州中医药大学第二附属医院省部共建中医湿证国家重点实验室，广州　511400
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.11.23
  CLC： R284;R285
- Published：15 June 2023，
  
  Received：16 October 2022，
  
  Revised：15 May 2023，
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刘芮诚,孔玲,孙野等.黄芪干预糖尿病视网膜病变的有效成分及其作用机制研究进展 ^Δ[J].中国药房,2023,34(11):1404-1408.

LIU Ruicheng,KONG Ling,SUN Ye,et al.Research progress about effective components of Astragali Radix in the intervention of diabetic retinopathy and its mechanism[J].ZHONGGUO YAOFANG,2023,34(11):1404-1408.
刘芮诚,孔玲,孙野等.黄芪干预糖尿病视网膜病变的有效成分及其作用机制研究进展 ^Δ[J].中国药房,2023,34(11):1404-1408. DOI： 10.6039/j.issn.1001-0408.2023.11.23.

LIU Ruicheng,KONG Ling,SUN Ye,et al.Research progress about effective components of Astragali Radix in the intervention of diabetic retinopathy and its mechanism[J].ZHONGGUO YAOFANG,2023,34(11):1404-1408. DOI： 10.6039/j.issn.1001-0408.2023.11.23.

摘要

糖尿病视网膜病变是糖尿病的一种常见并发症，对人类视力健康产生了很大威胁。近几年研究表明，黄芪中皂苷类、多糖类、黄酮类成分通过作用于核因子κB、缺氧诱导因子1α、神经胶质纤维酸性蛋白、谷氨酰胺合成酶、醛糖还原酶和多种微小核糖核酸等相关靶点，调节磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白、沉默信息调节因子1/核因子E2相关因子2、B细胞淋巴瘤2等信号通路，从而发挥抗炎、抗微血管病变、抗神经退行性病变、抗细胞凋亡的作用，进而达到治疗糖尿病视网膜病变的目的。

Abstract

Diabetic retinopathy （DR） is a common complication of diabetes， which causes a great threat to the health of human vision. Recent studies have shown that saponins， polysaccharides and flavonoids in Astragali Radix regulate phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway， silent information regulator 1/nuclear factor erythroid 2-related factor 2 pathway， B-cell lymphoma-2 and other signaling pathways by acting on nuclear factor-κB， hypoxia-inducible factor-1α， glial fibrillary acidic protein， glutamine synthetase， aldose reductase， multiple miRNA and other related targets， so as to exert anti-inflammatory， anti-microangiopathy， anti-neurodegenerative disease and anti-apoptosis， and then achieve the purpose of treating DR.

关键词

糖尿病视网膜病变黄芪有效成分作用机制

Keywords

Astragali Radixactive componentmechanisms

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