Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population

XU Hongyan; HUANG Jian; WU Along; XU Bingfa

doi:10.6039/j.issn.1001-0408.2023.13.23

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Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population

更新时间：2023-08-15

- Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population
- ZHONGGUO YAOFANG Vol. 34, Issue 13, Pages: 1661-1664(2023)
- 作者机构：
  
  1.安徽医科大学第三附属医院药学部，合肥　230061
  2.安徽医科大学药学院，合肥　230061
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.13.23
  CLC： R969.1;R978.1
- Published：15 July 2023，
  
  Received：11 November 2022，
  
  Revised：31 March 2023，
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徐红艳,黄健,武阿龙等.美罗培南药动学/药效学及特殊人群用药的研究进展 ^Δ[J].中国药房,2023,34(13):1661-1664.

XU Hongyan,HUANG Jian,WU Along,et al.Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population[J].ZHONGGUO YAOFANG,2023,34(13):1661-1664.
徐红艳,黄健,武阿龙等.美罗培南药动学/药效学及特殊人群用药的研究进展 ^Δ[J].中国药房,2023,34(13):1661-1664. DOI： 10.6039/j.issn.1001-0408.2023.13.23.

XU Hongyan,HUANG Jian,WU Along,et al.Research progress in pharmacokinetics/pharmacodynamics and drug use of meropenem in special population[J].ZHONGGUO YAOFANG,2023,34(13):1661-1664. DOI： 10.6039/j.issn.1001-0408.2023.13.23.

摘要

美罗培南是治疗多药耐药菌感染的首选药物，已广泛应用于临床，但特殊人群的生理病理特征会对美罗培南的药动学/药效学（PK/PD）参数产生影响，临床应用时需根据患者特征制定个体化给药方案。因此，本文总结了美罗培南在特殊人群中的PK/PD特点和应用，推荐美罗培南在儿童患者中给予10～40 mg/kg，q8 h；在老年患者中给予1 g，q8～12 h；在肾功能不全、接受连续静脉-静脉血液滤过和连续静脉-静脉血液透析的患者中给予0.75 g，q8 h；在肾功能亢进患者中给予1 g，q8 h延长输注至3 h或2 g，q8 h；在肝硬化患者中给予2 g负荷剂量后再给予1 g，q8 h。

Abstract

Meropenem is the first choice for the treatment of multi-drug-resistant bacterial infections， which has been widely used in clinical practice. However， the physiological and pathological characteristics of special populations have a significant impact on the pharmacokinetics/pharmacodynamics （PK/PD） parameters of meropenem， so it is necessary to develop individualized drug administration plan according to the characteristics of patients in clinical application. Therefore， this paper summarizes PK/PD characteristics and application of meropenem in special population， and recommends the dosage of meropenem as follows： 10-40 mg/kg， q8 h for children； 1 g， q8-12 h for elderly patients； 0.75 g， q8 h for the patients with renal insufficiency who received continuous veno-venous hemofiltration and continuous veno-venous hemodialysis； 1 g， q8 h prolonged infusion until 3 hours or 2 g， q8 h for patients with hyperrenal function； 1 g， q8 h after 2 g loading dose for patients with cirrhosis.

关键词

美罗培南药动学药效学药物相互作用治疗药物监测

Keywords

pharmacodynamicspharmacokineticsdrug interactiontherapeutic drug monitoring

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Related Institution

Clinical Pharmacology Center， the First Affiliated Hospital of Nanjing Medical University

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Dept. of Hematology， the First Affiliated Hospital of Shandong First Medical University（Shandong Provincial Qianfoshan Hospital）

Dept. of Clinical Pharmacy， the First Affiliated Hospital of Shandong First Medical University （Shandong Provincial Qianfoshan Hospital）/Shandong Engineering and Technology Research Center for Pediatric Drug Clinical Evaluation and Development/Shandong Medicine and Health Key Laboratory of Clinical Pharmacy

Dept. of Pediatrics， the First Affiliated Hospital of Shandong First Medical University （Shandong Provincial Qianfoshan Hospital）/Shandong Engineering and Technology Research Center for Pediatric Drug Clinical Evaluation and Development

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