浏览全部资源
扫码关注微信
- Journal Information
- Archive
- Submission
- For Reviewers
- Statement and Policies
Current status and prospect of composite nano-phototherapy agents in the phototherapy for breast cancer treatment
- ZHONGGUO YAOFANG Vol. 34, Issue 14, Pages: 1781-1787(2023)
- 作者机构：
1.山东中医药大学药学院，济南 250355
2.山东中医药大学中医学院，济南 250355
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2023.14.22
CLC： R943;R737.9Published：30 July 2023，
Received：05 January 2023，
Revised：26 June 2023，
扫 描 看 全 文
章瑾,王尚志,杨明睿等.复合纳米光疗剂在乳腺癌光疗法中的研究现状与展望 Δ[J].中国药房,2023,34(14):1781-1787.
ZHANG Jin,WANG Shangzhi,YANG Mingrui,et al.Current status and prospect of composite nano-phototherapy agents in the phototherapy for breast cancer treatment[J].ZHONGGUO YAOFANG,2023,34(14):1781-1787.
章瑾,王尚志,杨明睿等.复合纳米光疗剂在乳腺癌光疗法中的研究现状与展望 Δ[J].中国药房,2023,34(14):1781-1787. DOI： 10.6039/j.issn.1001-0408.2023.14.22.
ZHANG Jin,WANG Shangzhi,YANG Mingrui,et al.Current status and prospect of composite nano-phototherapy agents in the phototherapy for breast cancer treatment[J].ZHONGGUO YAOFANG,2023,34(14):1781-1787. DOI： 10.6039/j.issn.1001-0408.2023.14.22.
摘要
光疗法作为一种辅助替代疗法，因非侵入性的诊疗特点广泛用于乳腺癌的早期诊断与后期治疗。但现有光疗剂因疏水性及组织靶向性差、光稳定性低、体内毒副作用明显，限制了其应用范围。随着纳米技术的发展，新型复合纳米光疗剂应运而生。该文总结了近5年新型纳米光疗剂在乳腺癌光疗法中的最新进展，发现随着多功能纳米材料在乳腺癌成像诊疗一体化领域中的发展，经修饰改进后的光疗剂分别在改善光响应以提高光热转换或增加活性氧的生成、靶向肿瘤微环境/免疫细胞/癌细胞表面受体以实现药物的可控响应式释放、利用仿生材料及内源物质改善生物相容性等方面取得了进一步发展。虽然新型光疗剂在转移性乳腺癌模型的治疗中表现出高细胞杀伤率，并能有效抑制其复发转移，但在安全性和协同治疗兼容性等方面仍存在问题。未来研究不仅可以在光疗剂现有作用的基础上加以改进，还可以结合免疫疗法，开发给药途径更便捷的口服药物，以放大免疫反应，多途径协同抵御乳腺癌侵袭。
Abstract
As an adjuvant alternative therapy， phototherapy is widely used for early diagnosis and late treatment of breast cancer due to its non-invasive treatment characteristics. But the application of phototherapeutic agents has been limited in the clinic due to poor hydrophobicity and tissue targeting， low photostability， and obvious toxic side effects
in vivo
. With the development of nanotechnology， new composite nano-phototherapy agents have emerged. This paper summarizes the latest developments and findings of new composite nano-phototherapy agents for phototherapy in the field of breast cancer treatment in the past 5 years. With the development of multifunctional nanomaterials in the field of breast cancer imaging diagnosis and treatment， the modified phototherapy agent achieved further development respectively from improving light response to improve the light thermal conversion or increasing the generation of reactive oxygen species， targeting tumor microenvironment， immune cells and cancer cell surface receptors to achieve drug controllable response release， using biomimetic materials and endogenous substances to improve biocompatibility. Although phototherapeutic agents exhibit high cell-killing rates in the treatment of metastatic breast cancer models and effectively inhibit their recurrence and metastasis， problems remain regarding the safety and compatibility of synergistic therapy. Future studies can not only improve the existing effects of phototherapeutic agents， but also develop oral drugs with more convenient routes based on immunotherapy to amplify the immune response and resist breast cancer through multiple routes.
关键词
光疗剂纳米材料光热治疗光动力治疗乳腺癌
Keywords
nanomaterialsphotothermal therapyphotodynamic therapybreast cancer
references
SUNG H，FERLAY J，SIEGEL R L，et al. Global cancer statistics 2020：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin，2021，71（3）：209-249.
陈茂山，吕青. 《基于人口登记数据2000—2020年全球乳腺癌发病和死亡率分析》要点解读[J]. 中国胸心血管外科临床杂志，2022，29（4）：401-406.
SAMANTA K，SETUA S，KUMARI S，et al. Gemcitabine combination nano therapies for pancreatic cancer[J]. Pharmaceutics，2019，11（11）：574.
吴洪军. 用于乳腺癌治疗的叶酸靶向聚合物囊泡及OCTA/NIRF在体评估研究[D]. 北京：北京协和医学院，2022.
ALVES C G，LIMA-SOUSA R，MELO B L，et al. Heptamethine cyanine-loaded nanomaterials for cancer immuno-photothermal/photodynamic therapy：a review[J]. Pharmaceutics，2022，14（5）：1015.
REVURI V，RAJENDRAKUMAR S K，PARK M S，et al. Heat-confined tumor-docking reversible thermogel potentiates systemic antitumor immune response during near-infrared photothermal ablation in triple-negative breast cancer[J]. Adv Healthc Mater，2021，10（21）：e2100907.
WANG X N，LUO D，BASILION J P. Photodynamic therapy：targeting cancer biomarkers for the treatment of cancers[J]. Cancers，2021，13（12）：2992.
JIN F Y，QI J，ZHU M X，et al. NIR-triggered sequentially responsive nanocarriers amplified cascade synergistic effect of chemo-photodynamic therapy with inspired antitumor immunity[J]. ACS Appl Mater Interfaces，2020，12（29）：32372-32387.
DU C，DING Y，QIAN J W，et al. Achieving traceless ablation of solid tumors without recurrence by mild photothermal-chemotherapy of triple stimuli-responsive polymer-drug conjugate nanoparticles[J]. J Mater Chem B，2019，7（3）：415-432.
JIN F Y，QI J，LIU D，et al. Cancer-cell-biomimetic upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer[J]. J Control Release，2021，337：90-104.
HOWAILI F，ÖZLISELI E，KÜÇÜKTÜRKMEN B，et al. Stimuli-responsive，plasmonic nanogel for dual delivery of curcumin and photothermal therapy for cancer treatment[J]. Front Chem，2020，8：602941.
DING Y N，YANG R，YU W P，et al. Chitosan oligosaccharide decorated liposomes combined with TH302 for photodynamic therapy in triple negative breast cancer[J]. J Nanobiotechnology，2021，19（1）：147.
HOU Y J，YANG X X，LIU R Q，et al. Pathological mechanism of photodynamic therapy and photothermal therapy based on nanoparticles[J]. Int J Nanomedicine，2020，15：6827-6838.
ZHAO M，LIU J Z，TANG Y T，et al. Hyaluronidase responsive second near-infrared fluorescent nano complex for combined HER2 blockade and chemotherapy of HER2+ breast cancer[J]. Biomater Adv，2022，141：213115.
YIN Z B，JI Q，WU D，et al. H2O2-responsive gold nanoclusters@mesoporous silica@manganese dioxide nanozyme for off/on modulation and enhancement of magnetic resonance imaging and photodynamic therapy[J]. ACS Appl Mater Interfaces，2021，13（13）：14928-14937.
XU Z L，CHEN J，LI Y N，et al. Yolk-shell Fe3O4@carbon@platinum-chlorin e6 nanozyme for MRI-assisted sy-nergistic catalytic-photodynamic-photothermal tumor therapy[J]. J Colloid Interface Sci，2022，628（Pt A）：1033-1043.
LI Z R，FAN F，MA J Y，et al. Oxygen- and bubble-generating polymersomes for tumor-targeted and enhanced photothermal-photodynamic combination therapy[J]. Biomater Sci，2021，9（17）：5841-5853.
LI J W，ZHOU Y，XU J，et al. Water-soluble and degra-dable gelatin/polyaniline assemblies with a high photothermal conversion efficiency for pH-switchable precise photothermal therapy[J]. ACS Appl Mater Interfaces，2022，14（47）：52670-52683.
WANG T T，ZHANG H，HAN Y B，et al. Light-enhanced O2-evolving nanoparticles boost photodynamic therapy to elicit antitumor immunity[J]. ACS Appl Mater Interfaces，2019，11（18）：16367-16379.
AN P J，FAN F Y，GU D H，et al. Photothermal-reinforced and glutathione-triggered in situ cascaded nanocatalytic therapy[J]. J Control Release，2020，321：734-743.
LI K L，MA X T，HE S，et al. Ultrathin nanosheet-supported Ag@Ag2O core-shell nanoparticles with vastly enhanced photothermal conversion efficiency for NIR-Ⅱ-triggered photothermal therapy[J]. ACS Biomater Sci Eng，2022，8（2）：540-550.
CHU Z Y，TIAN T，TAO Z C，et al. Upconversion nanoparticles@AgBiS2 core-shell nanoparticles with cancer- cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers[J]. Bioact Mater，2022，17：71-80.
ZHANG Y H，ZHU X H，ZHANG J，et al. Synergistic upconversion photodynamic and photothermal therapy under cold near-infrared excitation[J]. J Colloid Interface Sci，2021，600：513-529.
WANG Q，QU B T，LI J，et al. Multifunctional MnO2/Ag3SbS3 nanotheranostic agent for single-laser-triggered tumor synergistic therapy in the NIR-Ⅱ biowindow[J]. ACS Appl Mater Interfaces，2022，14（4）：4980-4994.
LIU Y N，WEI C F，LIN A G，et al. Responsive functiona-lized MoSe2 nanosystem for highly efficient synergistic therapy of breast cancer[J]. Colloids Surf B Biointerfaces，2020，189：110820.
JIANG Q J，LIU L，LI Q Y，et al. NIR-laser-triggered gadolinium-doped carbon dots for magnetic resonance imaging，drug delivery and combined photothermal chemotherapy for triple negative breast cancer[J]. J Nanobiotechnology，2021，19（1）：64.
WEI C X，JIN X，WU C W，et al. Carbon spheres with high photothermal conversion efficiency for photothermal therapy of tumor[J]. Diam Relat Mater，2022，126：109048.
WANG L，LIU G H，HU Y P，et al. Doxorubicin-loaded polypyrrole nanovesicles for suppressing tumor metastasis through combining photothermotherapy and lymphatic system-targeted chemotherapy[J]. Nanoscale，2022，14（8）：3097-3111.
GAO P，WANG M Z，CHEN Y Y，et al. A COF-based nanoplatform for highly efficient cancer diagnosis，photodynamic therapy and prognosis[J]. Chem Sci，2020，11（26）：6882-6888.
SUN Q Q，TANG K，SONG L Q，et al. Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy[J]. Biomater Sci，2021，9（23）：7977-7983.
MA Y S，QIAN C T，MA L L，et al. High-stabilized polydopamine modified low eutectic fatty acids based on near-infrared response for breast cancer therapy[J]. J Photochem Photobiol B，2021，220：112213.
HAYAT S M G，BIANCONI V，PIRRO M，et al. CD47：role in the immune system and application to cancer therapy[J]. Cell Oncol，2020，43（1）：19-30.
LIU J，HE S S，LUO Y L，et al. Tumor-microenvironment-activatable polymer nano-immunomodulator for precision cancer photoimmunotherapy[J]. Adv Mater，2022，34（8）：e2106654.
CHEN Z，ZHAO P F，LUO Z Y，et al. Cancer cell membrane-biomimetic nanoparticles for homologous-targeting dual-modal imaging and photothermal therapy[J]. ACS Nano，2016，10（11）：10049-10057.
ZHAO P Q，XU Y L，JI W，et al. Biomimetic black phosphorus quantum dots-based photothermal therapy combined with anti-PD-L1 treatment inhibits recurrence and metastasis in triple-negative breast cancer[J]. J Nanobiotechnology，2021，19（1）：181.
LIN C H，CHEN Y C，HUANG P N. Preparation of multifunctional dopamine-coated zerovalent iron/reduced graphene oxide for targeted phototheragnosis in breast cancer[J]. Nanomaterials （Basel），2020，10（10）：1957.
PANIKAR S S，RAMÍREZ-GARCÍA G，VALLEJO-CARDONA A A，et al. Novel anti-HER2 peptide-conjugated theranostic nanoliposomes combining NaYF4：Yb，Er nanoparticles for NIR-activated bioimaging and chemo-photodynamic therapy against breast cancer[J]. Nanoscale，2019，11（43）：20598-20613.
YASOTHAMANI V，KARTHIKEYAN L，SHYAMSIVAPPAN S，et al. Synergistic effect of photothermally targeted NIR-responsive nanomedicine-induced immunogenic cell death for effective triple negative breast cancer therapy[J]. Biomacromolecules，2021，22（6）：2472-2490.
CHENG D，JI Y J，WANG B，et al. Dual-responsive nanohybrid based on degradable silica-coated gold nanorods for triple-combination therapy for breast cancer[J]. Acta Biomater，2021，128：435-446.
NIU S W，ZHANG X J， WILLIAMS G R，et al. Hollow mesoporous silica nanoparticles gated by chitosan-copper sulfide composites as theranostic agents for the treatment of breast cancer[J]. Acta Biomater，2021，126：408-420.
ZHENG S H，NGUYEN V D，SONG S Y，et al. Combined photothermal-chemotherapy of breast cancer by near infrared light responsive hyaluronic acid-decorated nanostructured lipid carriers[J]. Nanotechnology，2017，28（43）：435102.
ZHUANG B，CHEN T，HUANG Y Q，et al. Chemo-photothermal immunotherapy for eradication of orthotopic tumors and inhibition of metastasis by intratumoral injection of polydopamine versatile hydrogels[J]. Acta Pharm Sin B，2022，12（3）：1447-1459.
LIU T I，LU T Y，YANG Y C，et al. New combination treatment from ROS-induced sensitized radiotherapy with nanophototherapeutics to fully eradicate orthotopic breast cancer and inhibit metastasis[J]. Biomaterials，2020，257：120229.
PAN Y W，ZHOU S Q，LIU C，et al. Dendritic polyglycerol-conjugated gold nanostars for metabolism inhibition and targeted photothermal therapy in breast cancer stem cells[J]. Adv Healthc Mater，2022，11（8）：e2102272.
WANG Y，LI M S，LUO T，et al. Development of FL/MR dual-modal Au nanobipyramids for targeted cancer ima-ging and photothermal therapy[J]. Mater Sci Eng C Mater Biol Appl，2021，127：112190.
PAN Y，HE Y C，ZHAO X，et al. Engineered red blood cell membrane-coating salidroside/indocyanine green nanovesicles for high-efficiency hypoxic targeting phototherapy of triple-negative breast cancer[J]. Adv Healthc Mater，2022，11（17）：e2200962.
ZOR F，SELEK F N，ORLANDO G，et al. Biocompatibi-lity in regenerative nanomedicine[J]. Nanomedicine （Lond），2019，14（20）：2763-2775.
QIN Y，LIU T T，GUO M F，et al. Mild-heat-inducible sequentially released liposomal complex remodels the tumor microenvironment and reinforces anti-breast-cancer therapy[J]. Biomater Sci，2020，8（14）：3916-3925.
SHIN H H，CHOI H W，LIM J H，et al. Near-infrared light-triggered thermo-responsive poly（N-isopropylacryla-mide）-pyrrole nanocomposites for chemo-photothermal cancer therapy[J]. Nanoscale Res Lett，2020，15（1）：214.
MAO C Q，YEH S，FU J，et al. Delivery of an ectonucleotidase inhibitor with ROS-responsive nanoparticles overcomes adenosine-mediated cancer immunosuppression[J]. Sci Transl Med，2022，14（648）：eabh1261.
LI X，ZOU Q，ZHANG J，et al. Self-assembled dual-targeted epirubicin-hybrid polydopamine nanoparticles for combined chemo-photothermal therapy of triple-negative breast cancer[J]. Int J Nanomedicine，2020，15：6791-6811.
LIU X R，WANG C，MA H S，et al. Water-responsive hybrid nanoparticles codelivering ICG and DOX effectively treat breast cancer via hyperthermia-aided DOX func-tionality and drug penetration[J]. Adv Healthc Mater，2019，8（8）：e1801486.
HUANG Z Q，WEI G F，ZENG Z S，et al. Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor[J]. Therano-stics，2019，9（19）：5542-5557.
李婵莲，宋佳敏，陈美玲，等. 巨噬细胞膜仿生纳米递药系统在疾病靶向治疗中的应用[J]. 中国药房，2022，33（18）：2290-2294.
HUANG Y J，GUAN Z L，DAI X L，et al. Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer[J]. Nat Commun，2021，12（1）：4310.
0
Views
3
下载量
0
CSCD
- L-PDFDownload
- WORDDownload
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Address：8/F,129 Daping Main Street,Yuzhong District,Chongqing 400042,P.R.China
- Technical support is provided by Beijing Founder Electronics co., LTD 渝ICP备15012710号
公网安备50010302001817 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.