Literature analysis of atypical fractures associated with denosumab

ZHENG Yongfei; LIU Huina

doi:10.6039/j.issn.1001-0408.2023.16.15

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Literature analysis of atypical fractures associated with denosumab

更新时间：2023-08-24

- Literature analysis of atypical fractures associated with denosumab
- ZHONGGUO YAOFANG Vol. 34, Issue 16, Pages: 1999-2002(2023)
- 作者机构：
  
  郑州市骨科医院药学部，郑州　450052
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.16.15
  CLC： R969.3
- Published：30 August 2023，
  
  Received：12 January 2023，
  
  Revised：06 July 2023，
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郑永飞,刘慧娜.地舒单抗相关非典型骨折的文献分析[J].中国药房,2023,34(16):1999-2002.

ZHENG Yongfei,LIU Huina.Literature analysis of atypical fractures associated with denosumab[J].ZHONGGUO YAOFANG,2023,34(16):1999-2002.
郑永飞,刘慧娜.地舒单抗相关非典型骨折的文献分析[J].中国药房,2023,34(16):1999-2002. DOI： 10.6039/j.issn.1001-0408.2023.16.15.

ZHENG Yongfei,LIU Huina.Literature analysis of atypical fractures associated with denosumab[J].ZHONGGUO YAOFANG,2023,34(16):1999-2002. DOI： 10.6039/j.issn.1001-0408.2023.16.15.

摘要

目的

探讨地舒单抗相关非典型骨折（AF）的发生特点和规律，为临床合理用药提供参考。

方法

计算机检索PubMed、Web of Science、中国知网、万方数据、维普网，收集地舒单抗相关AF的个案报道，并进行描述性分析。

结果

共纳入文献19篇，涉及患者20例，其中男性3例、女性17例，平均年龄（69.80±15.39）岁。20例患者中，14例患者的原患疾病为骨质疏松症，6例为实体瘤骨转移和骨巨细胞瘤；AF发生时间为使用地舒单抗后3～132个月，平均（42.14±29.49）个月；14例患者在发生AF前出现了前驱症状；3例患者为尺骨骨折，17例为股骨骨折。绝大多数患者停药并采用手术固定治疗后，恢复良好，但有部分患者出现骨折延迟愈合。

结论

临床在长期使用地舒单抗时应警惕AF的发生；当患者出现大腿、腹股沟、髋关节和前臂疼痛等前驱症状时应及时就医，以保障用药安全。

Abstract

OBJECTIVE

To investigate the characteristics and regularity of denosumab-associated atypical fractures （AF）， so as to provide references for clinical rational use of drugs.

METHODS

The case reports of AF related to denosumab were retrieved from PubMed， Web of Science， CNKI， Wanfang data and VIP databases， and the reports were descriptively analyzed.

RESULTS

A total of 19 references were retrieved， including 20 patients. There were 3 males and 17 females， with an average age of （69.80±15.39） years. Among 20 patients， primary diseases of 14 patients were osteoporosis， and 6 cases were malignant tumor bone metastasis and giant cell tumor of bone. The occurrence time of AF ranged from 3 to 132 months after the administration of denosumab， with an average of （42.14±29.49） months. Fourteen cases had prodromal symptoms before AF. There were 3 cases of ulna fractures， and the remaining 17 cases were femoral fractures. The vast majority of patients recovered well after discontinuing medication and undergoing surgical fixation， but some patients experienced delayed fracture healing.

CONCLUSIONS

Long-term use of denosumab should be vigilant against AF. When patients experience prodromal symptoms such as thigh， groin， hip joint and forearm pain， they should seek medical attention in a timely manner to ensure medication safety.

关键词

地舒单抗非典型骨折骨质疏松症文献分析

Keywords

atypical fracturesosteoporosisliterature analysis

references

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