Optimization of water extraction process of Maxing kechuan granules

LIANG Dongqian; WANG Jingjing; WANG Xin; CHAI Tianchuan; LI Chunhua

doi:10.6039/j.issn.1001-0408.2023.17.09

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Optimization of water extraction process of Maxing kechuan granules

更新时间：2023-09-14

- Optimization of water extraction process of Maxing kechuan granules
- ZHONGGUO YAOFANG Vol. 34, Issue 17, Pages: 2095-2100(2023)
- 作者机构：
  
  1.河北中医药大学药学院，石家庄　050200
  2.保定市第一中医院脑病科，河北保定　071000
  3.河北省中医院制剂室，石家庄　050011
  4.河北省中药组方制剂技术创新中心，石家庄　050091
  5.河北省高校中药开发与产业化应用技术研发中心，石家庄　050091
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.17.09
  CLC： R917;R943
- Published：15 September 2023，
  
  Received：16 March 2023，
  
  Revised：28 July 2023，
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梁董茜,王晶晶,王欣等.麻杏咳喘颗粒的水提工艺优化 ^Δ[J].中国药房,2023,34(17):2095-2100.

LIANG Dongqian,WANG Jingjing,WANG Xin,et al.Optimization of water extraction process of Maxing kechuan granules[J].ZHONGGUO YAOFANG,2023,34(17):2095-2100.
梁董茜,王晶晶,王欣等.麻杏咳喘颗粒的水提工艺优化 ^Δ[J].中国药房,2023,34(17):2095-2100. DOI： 10.6039/j.issn.1001-0408.2023.17.09.

LIANG Dongqian,WANG Jingjing,WANG Xin,et al.Optimization of water extraction process of Maxing kechuan granules[J].ZHONGGUO YAOFANG,2023,34(17):2095-2100. DOI： 10.6039/j.issn.1001-0408.2023.17.09.

摘要

目的

优选麻杏咳喘颗粒的水提工艺。

方法

以药效成分盐酸麻黄碱、岩白菜素、升麻素苷、5-

-甲基维斯阿米醇苷、柚皮苷、橙皮苷含量及出膏率为考察指标，采用层次分析（AHP）-熵权法确定各指标权重，并计算综合评分作为响应值，在单因素实验的基础上采用Box-Behnken响应面法对各指标进行考察，优选麻杏咳喘颗粒的最佳水提工艺，并进行工艺验证。

结果

优选出麻杏咳喘颗粒的最佳水提工艺为浸泡时间40 min，加水量8倍，总提取时间180 min。经3次验证实验结果显示，综合评分为94.82分（RSD＝0.96%，

＝3），与预测值94.64分差异较小。

结论

优化后的麻杏咳喘颗粒水提工艺稳定可靠，可为该制剂的进一步开发提供参考。

Abstract

OBJECTIVE

To optimize the water extraction process of Maxing kechuan granules.

METHODS

With the contents of ephedrine hydrochloride， bergenin， prim-

-glucosylcimifugin， 5-

-methylvisamin， naringin and hesperidin and the rate of extraction as the evaluation indexes， the weight was determined by the analytic hierarchy process（APH）-entropy weight method， and the comprehensive score was calculated as the response value. Based on the single-factor test， the Box-Behnken response surface method was used to investigate the factors， and the best water extraction process of Maxing kechuan granules was optimized； process validation was also carried out.

RESULTS

The best water extraction process of Maxing kechuan granules optimized was as follows： soaking for 40 minutes， adding 8 times water， and extracting for 180 minutes. After three validation tests， the comprehensive score was 94.82 （RSD＝0.96%，

＝3）， which had a small difference from the predicted value of 94.64.

CONCLUSIONS

The water extraction process of Maxing kechuan granules is stable and reliable， which can provide a reference for the development of the preparation.

关键词

麻杏咳喘颗粒水提工艺Box-Behnken响应面法层次分析熵权法权重综合评分

Keywords

water extraction processBox-Behnken response surface methodanalytic hierarchy processentropy weight methodweightcomprehensive score

references

黄光强，郑飘雪，梁洁，等. Box-Behnken响应面法结合多指标综合评分法优化龙眼叶提取工艺[J]. 中国药房，2022，33（14）：1688-1693.

韩云凤，唐茜，石懿，等. 基于熵权法-层次分析法结合响应面法优化养阴润目颗粒的提取工艺[J]. 中国现代应用药学，2022，39（7）：896-903.

田楠楠，杨茜和，朱雅暄，等. 麻黄的化学成分及其药效作用和药代特征[J]. 中国中药杂志，2022，47（13）：3409-3424.

ZENG Q，ZHOU T T，ZHAO F Y，et al. p62-Nrf2 regulatory loop mediates the anti-pulmonary fibrosis effect of bergenin[J]. Antioxidants，2022，11（2）：307.

常潞，荆文光，程显隆，等. 防风化学成分药理作用研究进展及质量标志物预测分析[J]. 中国现代中药，2022，24（10）：2026-2039.

DE SOUZA A B F，DE MATOS N A，CASTRO T F，et al. Effects in vitro and in vivo of hesperidin administration in an experimental model of acute lung inflammation[J]. Free Radic Biol Med，2022，180：253-262.

ALAM M，AHSAN F，MAHMOOD T，et al. Meticulous parade on naringin respecting its pharmacological activities and novel formulations[J]. Avicenna J Phytomed，2022，12（5）：457-474.

王晶晶，程媛，忻晓东，等. Box-Behnken响应面法优化大黄泄浊颗粒提取工艺[J]. 时珍国医国药，2022，33（8）：1886-1889.

殷锦锦，杜培丽，谭湘萍，等. 基于AHP-TOPSIS法的阿托西班临床合理用药评价标准的建立与应用[J]. 中国药房，2023，34（1）：86-90.

卢英，邓攀，刘勇. 熵权法结合Box-Behnken响应面法优化肿节风药材的提取工艺[J]. 中国药房，2023，34（9）：1071-1075.

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