Effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats

ZHENG Huihui; ZHOU Longyue; ZHAO Boxin; WANG Chunxia

doi:10.6039/j.issn.1001-0408.2023.18.02

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Effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats

更新时间：2025-09-26

- Effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats
- ZHONGGUO YAOFANG Vol. 34, Issue 18, Pages: 2182-2186(2023)
- 作者机构：
  
  南方医科大学南方医院药学部，广州　510080
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.18.02
  CLC： R969.1
- Received：07 June 2023，
  
  Revised：2023-08-28，
  
  Accepted：30 August 2023，
  
  Published：30 September 2023
- 稿件说明：
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郑晖晖,周龙玥,赵博欣,等.抑乳调经颗粒对奥氮平在大鼠体内药动学的影响[J].中国药房,2023,34(18):2182-2186.

ZHENG Huihui,ZHOU Longyue,ZHAO Boxin,et al.Effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats[J].ZHONGGUO YAOFANG,2023,34(18):2182-2186.
郑晖晖,周龙玥,赵博欣,等.抑乳调经颗粒对奥氮平在大鼠体内药动学的影响[J].中国药房,2023,34(18):2182-2186. DOI： 10.6039/j.issn.1001-0408.2023.18.02.

ZHENG Huihui,ZHOU Longyue,ZHAO Boxin,et al.Effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats[J].ZHONGGUO YAOFANG,2023,34(18):2182-2186. DOI： 10.6039/j.issn.1001-0408.2023.18.02.

摘要

目的

探讨抑乳调经颗粒对奥氮平在大鼠体内药动学的影响。

方法

分别按单剂量给药和多剂量给药，将SD大鼠随机分4组，每组6只。A、B组大鼠分别单次灌胃奥氮平（5 mg/kg）、奥氮平（5 mg/kg）+抑乳调经颗粒（0.972 g/kg）；C、D组大鼠同法给药，每天1次，连续给药14 d。分别在给药前及末次给药后5、15、30 min和1、2、3、6、8、12、24 h于大鼠眼眶静脉丛采血，采用液相色谱-质谱技术测定大鼠的血药浓度，采用DAS 2.0软件计算药动学参数。

结果

与A组比较，B组大鼠24 h内的药-时曲线下面积（AUC

0－24 h

）、AUC

0－∞

、峰浓度（

max

）均显著降低（

＜0.05），24 h内的平均滞留时间（MRT

0－24 h

）、MRT

0－∞

、表观清除率（CLz/F）均显著延长（

＜0.05）；C组与D组大鼠的药动学参数比较，差异均无统计学意义（

＞0.05）。

结论

单次联用抑乳调经颗粒会抑制奥氮平在大鼠体内的吸收，长期联用抑乳调经颗粒对奥氮平的药动学过程无明显影响。

Abstract

OBJECTIVE

To investigate the effects of Yiru tiaojing granules on the pharmacokinetics of olanzapine in rats.

METHODS

SD rats were randomly divided into 4 groups according to single-dose administration and multiple-dose administration， with 6 rats in each group. Groups A and B were given olanzapine （5 mg/kg） or olanzapine （5 mg/kg）+Yiru tiaojing granules （0.972 g/kg） in a single gavage， and groups C and D were administered with the same method once a day for 14 d. Blood was collected from the orbital venous plexus before administration and 5， 15， 30 min and 1， 2， 3， 6， 8， 12， 24 h after the last administration， respectively. The blood concentration was determined by LC-MS， and the pharmacokinetic parameters were calculated by using DAS 2.0 software.

RESULTS

Compared with group A， group B showed a significant decrease in AUC

0－24 h

， AUC

0－∞

and

max

（

＜0.05）， and a significant prolongation of MRT

0－24 h

， MRT

0－∞

and CLz/F （

＜0.05）； there was no statistically significant difference in the pharmacokinetic parameters between group C and group D （

＞0.05）.

CONCLUSIONS

A single administration of Yiru tiaojing granules can inhibit the absorption of olanzapine in rats， and long-term administration of Yiru tiaojing granules does not have a significant effect on the pharmacokinetic process of olanzapine.

关键词

Keywords

references

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