Study on the optimization of processing technology of honey bran-fried Atractylodis Rhizoma and its anti-gastric ulcer effect

ZHU Wenting; LU Meixia; HUANG Yaojie; LIU Zhiwei; DING Yan; SHI Linfeng; YE Xide

doi:10.6039/j.issn.1001-0408.2023.18.08

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Study on the optimization of processing technology of honey bran-fried Atractylodis Rhizoma and its anti-gastric ulcer effect

更新时间：2025-09-26

- Study on the optimization of processing technology of honey bran-fried Atractylodis Rhizoma and its anti-gastric ulcer effect
- ZHONGGUO YAOFANG Vol. 34, Issue 18, Pages: 2213-2218(2023)
- 作者机构：
  
  1.江西中医药大学附属医院药学部，南昌　330006
  2.江西中医药大学药学院，南昌　330004
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.18.08
  CLC： R965;R283
- Received：03 April 2023，
  
  Revised：2023-07-18，
  
  Accepted：03 August 2023，
  
  Published：30 September 2023
- 稿件说明：
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朱文婷,陆美霞,黄瑶洁,等.蜜糠炒苍术炮制工艺优选及其抗胃溃疡作用研究[J].中国药房,2023,34(18):2213-2218.

ZHU Wenting,LU Meixia,HUANG Yaojie,et al.Study on the optimization of processing technology of honey bran-fried Atractylodis Rhizoma and its anti-gastric ulcer effect[J].ZHONGGUO YAOFANG,2023,34(18):2213-2218.
朱文婷,陆美霞,黄瑶洁,等.蜜糠炒苍术炮制工艺优选及其抗胃溃疡作用研究[J].中国药房,2023,34(18):2213-2218. DOI： 10.6039/j.issn.1001-0408.2023.18.08.

ZHU Wenting,LU Meixia,HUANG Yaojie,et al.Study on the optimization of processing technology of honey bran-fried Atractylodis Rhizoma and its anti-gastric ulcer effect[J].ZHONGGUO YAOFANG,2023,34(18):2213-2218. DOI： 10.6039/j.issn.1001-0408.2023.18.08.

摘要

目的

优选蜜糠炒苍术的炮制工艺，并对其炮制前后的抗胃溃疡作用进行比较。

方法

采用L

（3

）正交实验设计，结合熵权逼近理想解排序（TOPSIS）模型，以苍术酮、

-桉叶醇、白术内酯Ⅲ、苍术素含量的综合评分为评价指标，以辅料与药材比例、炒制温度、炒制时间为考察因素，优选蜜糠炒苍术的炮制工艺并验证。以无水乙醇灌胃建立胃溃疡小鼠模型，以复方氢氧化铝片为阳性对照，以血清炎症因子[白细胞介素2（IL-2）、IL-6、肿瘤坏死因子α（TNF-α）

]

含量、溃疡指数和胃溃疡抑制率为评价指标，比较生苍术和蜜糠炒苍术的抗胃溃疡作用。

结果

蜜糠炒苍术的最优炮制工艺为辅料与药材比例3∶10（g/g）、炮制温度140 ℃、炒制时间4 min。3次验证实验结果显示，最优工艺炮制所得蜜糠炒苍术中苍术酮等4种成分的含量较为稳定（RSD为3.47%～5.80%，

＝3），综合评分为95.53%～95.89%（RSD＝0.21%，

＝3）。生苍术和蜜糠炒苍术均可不同程度地升高胃溃疡模型小鼠血清IL-2含量，降低其血清IL-6、TNF-α含量，蜜糠炒苍术可显著降低其溃疡指数（

＜0.05或

＜0.01）；蜜糠炒苍术对上述指标的改善作用普遍优于同剂量生苍术（

＜0.05或

＜0.01）；低、中、高剂量生苍术和蜜糠炒苍术对小鼠胃溃疡的抑制率分别为9.18%、19.30%、30.70%和50.32%、61.39%、53.16%。

结论

优选出的蜜糠炒苍术炮制工艺稳定、可行，且苍术经蜜糠炒制后抗胃溃疡的作用有所增强。

Abstract

OBJECTIVE

To optimize the processing technology of honey bran-fried Atractylodis Rhizoma， and to compare the anti-gastric ulcer effect before and after processing.

METHODS

Combing with entropy-weight and technique for order preference by similarity to ideal solution model， L

（3

） orthogonal experiment design was adopted to optimize the processing technology of honey bran-fried Atractylodis Rhizoma using the comprehensive score of the contents of atractylone，

-cineole， atractylenolide Ⅲ and atractylodine as evaluation index， using the ratio of excipients to medicine， frying temperature and frying time as factors. The validation tests were conducted. The gastric ulcer model of mice was induced by intragastrical administration of anhydrous ethanol；using Compound aluminum hydroxide tablet as positive control， anti-gastric ulcer effect of Atractylodis Rhizoma was compared with that of honey bran-fried Atractylodis Rhizoma using the contents of serum inflammato

ry factors [interleukin-2 （IL-2）， IL-6， tumor necrosis factor-α （TNF-α）

]

， ulcer index and inhibitory rate of gastric ulcer as evaluation indexes.

RESULTS

The optimal processing technology of honey bran-fried Atractylodis Rhizoma was as follows：ratio of adjuvant and medicinal materials of 3∶10 （g/g）， frying temperature at 140 ℃ and frying time of 4 min. Results of 3 validation tests showed that the contents of 4 components （including atractylone）， in honey bran-fried Atractylodis Rhizoma processed by the optimal technology kept stable （RSDs were 3.47%-5.80%，

＝3）； the comprehensive scores were 95.53%-95.89% （RSD＝0.21%，

＝3）. Atractylodis Rhizoma and honey bran-fried Atractylodis Rhizoma could increase the serum content of IL-2 in mice， but reduce serum contents of IL-6 and TNF-α to varying degrees； honey bran-fried Atractylodis Rhizoma could significantly decrease its ulcer indexes （

＜0.05 or

＜0.01）； the improvement effect of honey bran-fried Atractylodis Rhizoma on the above indicators was generally better than that of the same dosage of Atractylodis Rhizoma （

＜0.05 or

＜0.01）. The inhibitory rates of low-dose， medium-dose and high-dose Atractylodis Rhizoma and honey bran-fried Atractylodis Rhizoma to gastric ulcer in mice were 9.18%， 19.30%， 30.70%， and 50.32%， 61.39%， 53.16%， respectively.

CONCLUSIONS

The optimal processing technology of honey bran-fried Atractylodis Rhizoma is stable and feasible， and the anti-gastric ulcer effect of Atractylodis Rhizoma has been enhanced after being fried with honey bran.

关键词

Keywords

references

国家药典委员会 . 中华人民共和国药典：一部 [M ] . 2020年版 . 北京：中国医药科技出版社， 2020 ： 168 .

陈天阳，张萍，成扬 . 苍术酮含量测定方法、燥性及药理作用的研究进展 [J ] . 中成药， 2022 ， 44 （ 6 ）： 1902 - 1905 .

王孝涛 . 历代中药炮制法汇典：现代部分 [M ] . 南昌：江西科学技术出版社， 1998 ： 25 - 26 .

邓怡芳，祝婧，钟凌云，等 . 建昌帮特色辅料蜜糠的应用现状及研究进展 [J ] . 江西中医药大学学报， 2021 ， 33 （ 6 ）： 116 - 119 .

邓爱平，李颖，吴志涛，等 . 苍术化学成分和药理的研究进展 [J ] . 中国中药杂志， 2016 ， 41 （ 21 ）： 3904 - 3913 .

张明发，沈雅琴 . 中药苍术炮制前后药理作用的研究进展 [J ] . 抗感染药学， 2017 ， 14 （ 3 ）： 481 - 485 .

KIMURA Y ， SUMIYOSHI M . Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice [J ] . J Ethnopharmacol ， 2012 ， 141 （ 1 ）： 530 - 536 .

张明发，沈雅琴 . 苍术及其活性成分β-桉叶醇的神经药理作用的研究进展 [J ] . 抗感染药学， 2017 ， 14 （ 1 ）： 6 - 11 .

PLENGSURIYAKARN T ， MATSUDA N ， KARBWANG J ， et al . Anticancer activity of Atractylodes lancea （Thunb.） DC in a hamster model and application of PET-CT for early detection and monitoring progression of cholangiocarcinoma [J ] . Asian Pac J Cancer Prev ， 2015 ， 16 （ 15 ）： 6279 - 6284 .

于艳，袁媛，贾天柱，等 . 茅苍术麸炒前后对乙酸致胃溃疡大鼠胃动素和胃泌素的影响 [J ] . 药物分析杂志， 2016 ， 36 （ 6 ）： 968 - 973 .

吴红伟，李东辉，边甜甜，等 . 基于响应面法结合熵权法多指标优选黄芪药材产地加工炮制一体化工艺 [J ] . 中草药， 2021 ， 52 （ 19 ）： 5854 - 5861 .

冯晓莉，李成义，魏舒畅，等 . 基于主观赋值结合熵权TOPSIS法综合评价不同产地黄花菜质量 [J ] . 中国现代应用药学， 2022 ， 39 （ 22 ）： 2927 - 2934 .

吴红伟，李东辉，张育贵，等 . 基于熵权TOPSIS模型对不同加工方式黄芪药材质量的综合评价 [J ] . 中国药学杂志， 2021 ， 56 （ 16 ）： 1325 - 1331 .

魏伟，吴希美，李元建 . 药理实验方法学：第4版 [M ] . 北京：人民卫生出版社， 2010 ： 69 - 73 .

杨雪晴，徐伟，肖春萍，等 . 米泔水制北苍术炮制工艺及其抗腹泻药效作用研究 [J ] . 中草药， 2022 ， 53 （ 1 ）： 78 - 86 .

赵玉霞 . 樟帮特色米泔漂苍术工艺及药效学研究 [D ] . 南昌：江西中医药大学， 2019 .

WEN Z ， YOU X K ， LIU B ， et al . Formation of atractylone liposomes by rapid expansion from supercritical to surfactant solution [J ] . Asia Pac J Chem Eng ， 2011 ， 6 （ 4 ）： 624 - 630 .

XUE Q X ， ZHOU Z J ， YIN X ， et al . Research progress on chemical constituents and pharmacological effects of Atractylodes chinensis [C ] // 2020 2nd International Confe-rence on Medical Sciences and Biological Engineering ， London ： Francis Academic Press ， 2020 ： 88 - 91 .

HAN N R ， MOON P D ， NAM S Y ， et al . Inhibitory effects of atractylone on mast cell-mediated allergic reactions [J ] . Chem Biol Interact ， 2016 ， 258 ： 59 - 68 .

刘梦云，秦祎苒，刘秋怡，等 . 基于正交试验设计-熵权逼近理想解排序法（TOPSIS）优选巴戟天酒炙工艺及炮制前后药效对比研究 [J ] . 中草药， 2021 ， 52 （ 20 ）： 6208 - 6215 .

朱卫东，杜承勇，吴勇 . 一种基于相关系数矩阵的TOPSIS决策方法 [J ] . 数学的实践与认识， 2014 ， 44 （ 4 ）： 33 - 38 .

YU Y ， JIA T Z ， CAI Q ， et al . Comparison of the anti-ulcer activity between the crude and bran-processed Atractylodes lancea in the rat model of gastric ulcer induced by acetic acid [J ] . J Ethnopharmacol ， 2015 ， 160 ： 211 - 218 .

XU L ， SONG X L ， SU L L ， et al . New therapeutic strategies based on IL-2 to modulate Treg cells for autoimmune diseases [J ] . Int Immunopharmacol ， 2019 ， 72 ： 322 - 329 .

于艳，贾天柱，才谦 . 茅苍术及其麸炒品对胃溃疡大鼠抗炎作用的比较研究 [J ] . 中国中药杂志， 2016 ， 41 （ 4 ）： 705 - 710 .

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