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Intervention research status of traditional Chinese medicine monomers on autoimmune diseases by regulating Th17/Treg axis based on gut microbiota
- ZHONGGUO YAOFANG Vol. 34, Issue 20, Pages: 2550-2555(2023)
- 作者机构：
河南中医药大学第一附属医院心脏中心，郑州 450003
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2023.20.19
CLC： R965Published：30 October 2023，
Received：11 May 2023，
Revised：08 October 2023，
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黄金雨,董政委,王永霞.中药单体基于肠道菌群调节Th17/Treg轴对自身免疫性疾病的干预研究现状 Δ[J].中国药房,2023,34(20):2550-2555.
HUANG Jinyu,DONG Zhengwei,WANG Yongxia.Intervention research status of traditional Chinese medicine monomers on autoimmune diseases by regulating Th17/Treg axis based on gut microbiota[J].ZHONGGUO YAOFANG,2023,34(20):2550-2555.
黄金雨,董政委,王永霞.中药单体基于肠道菌群调节Th17/Treg轴对自身免疫性疾病的干预研究现状 Δ[J].中国药房,2023,34(20):2550-2555. DOI： 10.6039/j.issn.1001-0408.2023.20.19.
HUANG Jinyu,DONG Zhengwei,WANG Yongxia.Intervention research status of traditional Chinese medicine monomers on autoimmune diseases by regulating Th17/Treg axis based on gut microbiota[J].ZHONGGUO YAOFANG,2023,34(20):2550-2555. DOI： 10.6039/j.issn.1001-0408.2023.20.19.
摘要
自身免疫性疾病（ADs）是一类机体对自身抗原发生免疫反应而导致自身组织损害的疾病。促炎性的辅助性T细胞17（Th17）和抗炎性的调节性T细胞（Treg）在功能上相互拮抗，两者间的免疫失衡及相关细胞因子失调与多种ADs发生密切相关。大量证据表明，肠道菌群可通过调节细胞因子产生、调控转录因子表达、影响能量代谢等调节Th17/Treg分化，重建自身免疫耐受，延缓ADs进程。本文综述了红景天苷、人参皂苷Rg
1
、白芍总苷、熊果酸等中药单体基于肠道菌群调节Th17/Treg分化平衡途径在干预溃疡性结肠炎、类风湿性关节炎、1型糖尿病等ADs中的作用，结果显示其作用机制可能为恢复促炎因子与抗炎因子平衡从而缓解肠黏膜屏障受损、降低滑膜血管新生及改善胰腺β细胞破坏等。这可为ADs的中西医结合防治提供思路。
Abstract
Autoimmune diseases（ADs） are diseases in which the body’s immune tolerance is impaired， causing damage to its tissues. The pro-inflammatory helper T cell 17 （Th17） and anti-inflammatory regulatory T cell （Treg） are functionally antagonistic to each other， and the immune imbalance between them and the imbalance of related inflammatory factors are closely related to the occurrence of a variety of ADs. Plenty of evidence has shown that gut microbiota can regulate Th17/Treg differentiation， rebuild immune tolerance and delay the ADs process through regulating cytokine production， transcription factor expression and energy metabolism. This paper reviews the intervention effects of traditional Chinese medicine（TCM） monomers on the common ADs by regulating Th17/Treg differentiation balance based on intestinal flora： ulcerative colitis，rheumatoid arthritis and diabetes mellitus type 1. It is found that its mechanism of action may be to restore the balance of pro-inflammatory factors and anti-inflammatory factors to alleviate intestinal mucosal barrier damage， reduce synovial angiogenesis and improve pancreatic β cell destruction， which provides some ideas for the prevention and treatment of ADs with integrated traditional Chinese and western medicine.
关键词
中药单体自身免疫性疾病肠道菌群辅助性T细胞17调节性T细胞
Keywords
autoimmune diseasesgut microbiotahelper T cell 17regulatory T cell
references
COOPER G S，BYNUM M L K，SOMERS E C. Recent insights in the epidemiology of autoimmune diseases：improved prevalence estimates and understanding of cluste-ring of diseases[J]. J Autoimmun，2009，33（3/4）：197-207.
ABDEL-WAHAB N，SHAH M，LOPEZ-OLIVO M A，et al. Use of immune checkpoint inhibitors in the treatment of patients with cancer and preexisting autoimmune di-sease：a systematic review[J]. Ann Intern Med，2018，168（2）：121-130.
MICHAUDEL C，SOKOL H. The gut microbiota at the service of immunometabolism[J]. Cell Metab，2020，32（4）：514-523.
TORCHINSKY M B，BLANDER J M. T helper 17 cells：discovery，function，and physiological trigger[J]. Cell Mol Life Sci，2010，67（9）：1407-1421.
LEE G R. The balance of Th17 versus Treg cells in autoimmunity[J]. Int J Mol Sci，2018，19（3）：730.
OUYANG W J，KOLLS J K，ZHENG Y. The biological functions of T helper 17 cell effector cytokines in inflammation[J]. Immunity，2008，28（4）：454-467.
OMENETTI S，PIZARRO T T. The Treg/Th17 axis：a dynamic balance regulated by the gut microbiome[J]. Front Immunol，2015，6：639.
BUNTE K，BEIKLER T. Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases[J]. Int J Mol Sci，2019，20（14）：3394.
KUROLAP A，ESHACH ADIV O，KONNIKOVA L，et al. A unique presentation of infantile-onset colitis and eosinophilic disease without recurrent infections resulting from a novel homozygous CARMIL2 variant[J]. J Clin Immunol，2019，39（4）：430-439.
FASCHING P，STRADNER M，GRANINGER W，et al. Therapeutic potential of targeting the Th17/Treg axis in autoimmune disorders[J]. Molecules，2017，22（1）：134.
KAMADA N，SEO S U，CHEN G Y，et al. Role of the gut microbiota in immunity and inflammatory disease[J]. Nat Rev Immunol，2013，13（5）：321-335.
李思慧，吴巧凤. 肠道菌群对Th17/Treg免疫平衡和炎症性肠病影响的研究进展[J]. 免疫学杂志，2019，35（8）：722-726.
LI S H，WU Q F. The progress of the roles of gut flora in Th17/Treg axis balance and inflammatory bowel diseases[J]. Immunol J，2019，35（8）：722-726.
LÜHRS H，GERKE T，MÜLLER J G，et al. Butyrate inhibits NF-kappaB activation in lamina propria macrophages of patients with ulcerative colitis[J]. Scand J Gastroenterol，2002，37（4）：458-466.
BOPANNA S，ANANTHAKRISHNAN A N，KEDIA S，et al. Risk of colorectal cancer in Asian patients with ulcera-tive colitis：a systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol，2017，2（4）：269-276.
LIU X M，ZHOU M X，DAI Z Z，et al. Salidroside alle-viates ulcerative colitis via inhibiting macrophage pyroptosis and repairing the dysbacteriosis-associated Th17/Treg imbalance[J]. Phytother Res，2023，37（2）：367-382.
ZHANG R，ZHANG Q Q，CHEN Y N，et al. Combined treatment with Rg1 and adipose-derived stem cells alle-viates DSS-induced colitis in a mouse model[J]. Stem Cell Res Ther，2022，13（1）：272.
张彩，田志刚. ILC细胞与自身炎症性疾病[J]. 中国免疫学杂志，2019，35（6）：641-647.
ZHANG C，TIAN Z G. Innate lymphoid cells and inflammatory diseases[J]. Chin J Immunol，2019，35（6）：641-647.
DONG Y L，FAN H，ZHANG Z，et al. Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway[J]. Int J Biol Sci，2022，18（4）：1381-1397.
甘金刚，樊海南，张志强. 盐酸小檗碱对溃疡性结肠炎患者肠道菌群及免疫状态的影响[J]. 中国中西医结合消化杂志，2020，28（12）：949-953.
GAN J G，FAN H N，ZHANG Z Q. Effects of chlorhexidine hydrochloride on intestinal flora and immune status in patients with ulcerative colitis[J]. Chin J Integr Tradit West Med Dig，2020，28（12）：949-953.
XIAO Q P，ZHONG Y B，KANG Z P，et al. Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis[J]. Phytother Res，2022，36（4）：1708-1723.
WANG Y J，LI Q M，ZHA X Q，et al. Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function，modulating intestinal microbiota，and reducing oxidative stress and inflammatory responses[J]. Food Funct，2022，13（1）：143-160.
WEN S T，HE L，ZHONG Z T，et al. Stigmasterol restores the balance of Treg/Th17 cells by activating the butyrate-PPARγ axis in colitis[J]. Front Immunol，2021，12：741934.
HUA Y Z，LIU R Q，LU M，et al. Juglone regulates gut microbiota and Th17/Treg balance in DSS-induced ulce-rative colitis[J]. Int Immunopharmacol，2021，97：107683.
WU J W，WEI Z H，CHENG P，et al. Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis[J]. Therano-stics，2020，10（23）：10665-10679.
LIU Y J，TANG B，WANG F C，et al. Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner[J]. Thera-nostics，2020，10（12）：5225-5241.
ZHU L，XU L Z，ZHAO S，et al. Protective effect of bai-calin on the regulation of Treg/Th17 balance，gut microbiota and short-chain fatty acids in rats with ulcerative colitis[J]. Appl Microbiol Biotechnol，2020，104（12）：5449-5460.
JI J J，GE X Y，CHEN Y G，et al. Daphnetin ameliorates experimental colitis by modulating microbiota composition and Treg/Th17 balance[J]. FASEB J，2019，33（8）：9308-9322.
胡红锋，詹雅珍，丁金囡，等. 瑞香素改善结肠炎疗效的临床观察及机制初探[J]. 世界华人消化杂志，2021，29（5）：223-230.
HU H F，ZHAN Y Z，DING J N，et al. Clinical observation and preliminary study of mechanism of daphnetin in improving therapeutic effects for colitis[J]. World Chin J Dig，2021，29（5）：223-230.
ALRAFAS H R，BUSBEE P B，NAGARKATTI M，et al. Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells[J]. J Leukoc Biol，2019，106（2）：467-480.
JING Y P，LI A P，LIU Z R，et al. Absorption of Codonopsis pilosula saponins by coexisting polysaccharides alle-viates gut microbial dysbiosis with dextran sulfate sodium-induced colitis in model mice[J]. Biomed Res Int，2018，2018：1781036.
杨阳. 马齿苋多糖改善溃疡性结肠炎小鼠的作用及相关机制研究[D]. 大庆：黑龙江八一农垦大学，2022.
YANG Y. Studys of Portulaca oleracea L. polysaccharide on the effect and mechanism in ulcerative colitis mice[D]. Daqing：Heilongjiang Bayi Agricultural University，2022.
YOKOTA K. Osteoclast differentiation in rheumatoid arthritis[J]. Immunol Med，2023：1-6.
PENG J E，LU X R，XIE K L，et al. Dynamic alterations in the gut microbiota of collagen-induced arthritis rats following the prolonged administration of total glucosides of paeony[J]. Front Cell Infect Microbiol，2019，9：204.
姜冀，方海川，金晓畅，等. 白藜芦醇通过重塑肠道菌群改善类风湿性关节炎的作用机制研究[J]. 新中医，2022，54（1）：8-14.
JIANG J，FANG H C，JIN X C，et al. Mechanism of resveratrol improving rheumatoid arthritis by remodeling intestinal flora[J]. N Chin Med，2022，54（1）：8-14.
陶伟莉. 老鹳草多糖提取工艺的优化及治疗类风湿性关节炎的药效学研究[D]. 汕头：汕头大学，2022.
TAO W L. Efficient extraction and pharmacodynamic study on rheumatoid arthritis treatment of polysaccharide from Geranium wilfordii maxim[D]. Shantou：Shantou University，2022.
EMAMAULLEE J A，DAVIS J，MERANI S，et al. Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice[J]. Diabetes，2009，58（6）：1302-1311.
CHEN W W，YU Y Y，LIU Y，et al. Ursolic acid regulates gut microbiota and corrects the imbalance of Th17/Treg cells in T1DM rats[J]. PLoS One，2022，17（11）：e0277061.
LUO C，YANG D Y，HOU C，et al. Paeoniflorin protects NOD mice from T1D through regulating gut microbiota and TLR4 mediated myD88/TRIF pathway[J]. Exp Cell Res，2023，422（1）：113429.
LI X Q，CHEN Y，DAI G C，et al. Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice[J]. J Ethnopharmacol，2021，272：113934.
JIN B，ZHANG C X，GENG Y，et al. Therapeutic effect of ginsenoside Rd on experimental autoimmune encephalomyelitis model mice：regulation of inflammation and Treg/Th17 cell balance[J]. Mediators Inflamm，2020，2020：8827527.
DU Z Y，WANG Q F，HUANG X Y，et al. Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis[J]. Int Immunopharmacol，2020，81：106270.
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