浏览全部资源
扫码关注微信
江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
Published:30 October 2023,
Received:28 April 2023,
Revised:12 September 2023,
扫 描 看 全 文
叶盛航,张煜薇,孟晓伟等.大豆苷元通过雌激素样作用防治骨质疏松症的机制研究现状 Δ[J].中国药房,2023,34(20):2556-2560.
YE Shenghang,ZHANG Yuwei,MENG Xiaowei,et al.Mechanism research status of daidzein in the prevention and treatment of osteoporosis through estrogen-like effect[J].ZHONGGUO YAOFANG,2023,34(20):2556-2560.
叶盛航,张煜薇,孟晓伟等.大豆苷元通过雌激素样作用防治骨质疏松症的机制研究现状 Δ[J].中国药房,2023,34(20):2556-2560. DOI: 10.6039/j.issn.1001-0408.2023.20.20.
YE Shenghang,ZHANG Yuwei,MENG Xiaowei,et al.Mechanism research status of daidzein in the prevention and treatment of osteoporosis through estrogen-like effect[J].ZHONGGUO YAOFANG,2023,34(20):2556-2560. DOI: 10.6039/j.issn.1001-0408.2023.20.20.
骨质疏松症作为一种高发病率、高致残率的全身性骨病,已成为近年来的研究热点。大豆异黄酮中的大豆苷元可以与雌激素受体结合,模拟雌激素样作用防治骨质疏松症,其作用机制包括:通过激活Wnt信号通路来促进成骨细胞形成和分化,提高骨密度,改善骨组织健康;通过降低核因子κB受体激活蛋白配体/骨保护素比例,下调巨噬细胞集落刺激因子(M-CSF)的表达来抑制破骨细胞分化,减缓骨吸收;协同抗氧化和调节免疫,以达到预防和治疗骨质疏松症的目的。此外,不同剂量的大豆苷元对骨密度和骨质疏松会产生不同的效应,这可能与研究设计、样本选择和个体差异等因素有关。
Osteoporosis, as a systemic bone disease with high incidence rate and high disability rate, has become a research hotspot in recent years. The daidzein in soybean isoflavones can bind with estrogen receptors, simulating the prevention and treatment of osteoporosis with estrogen-like effect. Its mechanism of action includes promoting osteoblast formation and differentiation by activating the Wnt signaling pathway, increasing bone density, and improving bone tissue health; inhibiting osteoclast differentiation and slowing down bone resorption by reducing receptor activator of nuclear factors κB ligand/osteoprotegerin ratio, downregulating the expression of macrophage colony-stimulating factor (M-CSF); collaborating antioxidant and immune regulation to achieve the goal of preventing and treating osteoporosis. In addition, different doses of daidzein have different effects on bone density and osteoporosis, which may be related to factors such as study design, sample selection, and individual differences.
大豆苷元骨质疏松症雌激素样作用作用机制
osteoporosisestrogen-like effectmechanism
何姣姣,陈玉林,张敏,等.肠道菌群在骨质疏松症发病机制中的研究[J].中国骨质疏松杂志,2023,29(8):1197-1202.
HE J J,CHEN Y L,ZHANG M,et al. Study on the role of intestinal microflora in the pathogenesis of osteoporosis[J].Chin J Osteoporos,2023,29(8):1197-1202.
孙强. 大豆苷元对大鼠糖皮质激素性骨质疏松的预防作用研究[D]. 西安:第四军医大学,2013.
SUN Q. Protective effect of daidzein on glucocorticoid-induced osteoporosis rats[D]. Xi’an:The Fourth Military Medical University,2013.
陈嘉序,陈如扬,连媛,等. 大豆异黄酮的生物转化及功能活性研究进展[J]. 食品研究与开发,2021,42(9):176-182.
CHEN J X,CHEN R Y,LIAN Y,et al. Progress in microbial conversion and functional activity of soy isoflavones[J]. Food Res Dev,2021,42(9):176-182.
张清文,卫俊杰. 糖尿病性骨质疏松症发病机制的研究进展[J]. 现代临床医学,2022,48(5):378-380.
ZHANG Q W,WEI J J. Research progress on pathoge-nesis of diabetic osteoporosis[J]. J Mod Clin Med,2022,48(5):378-380.
程丛丛,李云秀,袁海涛,等. Wnt/β-catenin通路成分Axin和TCF4在卵巢癌中的研究进展[J]. 中国生育健康杂志,2021,32(1):83-84,101.
CHENG C C,LI Y X,YUAN H T,et al. Research pro-gress of Wnt/β-catenin pathway components Axin and TCF4 in ovarian cancer[J]. Chin J Reprod Heath,2021,32(1):83-84,101.
刘彦邑,黄艳. Wnt通路对不同组织中巨噬细胞功能影响的研究进展[J]. 中国药学杂志,2019,54(14):1132-1136.
LIU Y Y,HUANG Y. Advances in research on the effects of Wnt pathway on macrophage function in different tissues[J]. Chin Pharm J,2019,54(14):1132-1136.
曾克武,王学美,富宏,等. 淫羊藿苷通过Wnt/β-catenin信号通路抑制淀粉样蛋白Aβ25-35所诱导的神经毒性[J]. 中国药学杂志,2011,46(22):1719-1722.
ZENG K W,WANG X M,FU H,et al. Inhibition of β-amyloid protein(Aβ25-35)-induced neurotoxicity by icariin via Wnt/β-catenin signaling pathway[J]. Chin Pharm J,2011,46(22):1719-1722.
吴娟,吴勇军,李智,等. 肿瘤中Dapper蛋白家族表观遗传调控的研究进展[J]. 中国临床药理学与治疗学,2019,24(12):1434-1440.
WU J,WU Y J,LI Z,et al. Epigenetic regulation of Dapper family proteins in cancer[J]. Chin J Clin Pharmacol Ther,2019,24(12):1434-1440.
KIM M H,PARK J S,SEO M S,et al. Genistein and daidzein repress adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells via Wnt/β-catenin signalling or lipolysis[J]. Cell Prolif,2010,43(6):594-605.
张洁,田艾. M2巨噬细胞参与骨再生相关信号通路的作用与机制[J]. 中国组织工程研究,2023,27(2):314-321.
ZHANG J,TIAN A. Advances in the signaling pathway of M2 macrophages involved in bone regeneration[J]. Chin J Tissue Eng Res,2023,27(2):314-321.
王晨越,吴莉沙,汤承博,等. Wnt/β-连环蛋白通路在免疫检查点抑制剂耐药中作用的研究进展[J]. 上海大学学报(自然科学版),2023,29(2):224-233.
WANG C Y,WU L S,TANG C B,et al. Progress in research on the role of the Wnt/β-catenin pathway in immune checkpoint inhibitor resistance[J]. J Shanghai Univ Nat Sci Ed,2023,29(2):224-233.
PENG S L,GAO Y J,SHI S R,et al. LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation[J]. Cell Prolif,2022,55(1):e13174.
柯可,谢志坚,杨晓峰. 黄酮类化合物对成骨细胞作用机制的研究进展[J]. 中国新药与临床杂志,2015,34(2):81-86.
KE K,XIE Z J,YANG X F. Research progress on effect and mechanism of flavonoids on osteoblast[J]. Chin J N Drugs Clin Remedies,2015,34(2):81-86.
章文娟,谢保平,李伟娟,等. 补骨脂素抑制破骨细胞形成及其机制的实验研究[J]. 第三军医大学学报,2017,39(7):641-645.
ZHANG W J,XIE B P,LI W J,et al. Inhibitory effect of psoralen on osteoclast formation and its underlying mechanism in vitro[J]. J Third Mil Med Univ,2017,39(7):641-645.
王想福,孙凤歧,叶丙霖,等. 破骨细胞与骨质疏松症的关系研究进展[J]. 中国骨质疏松杂志,2015,21(11):1420-1424.
WANG X F,SUN F Q,YE B L,et al. Research progress in the relationship between osteoclasts and osteoporosis[J]. Chin J Osteoporos,2015,21(11):1420-1424.
虞凡. il-17rc基因敲除对小鼠椎体松质骨结构的影响[D]. 南昌:南昌大学,2022.
YU F. Using transgenic mice to explore the effect of il-17rc gene knockout on bone metabolism[D]. Nanchang:Nanchang University,2022.
李家乐,罗达胜,郑刘杰,等.人骨关节炎软骨细胞上调成骨细胞中骨保护素的作用途径[J/OL].中国组织工程研究,2023:1-8(2023-08-29)[2023-09-03].https://kns.cnki.net/kcms/detail/21.1581.R.20230828.1448.012.html.DOI:10.12307/2024.419https://kns.cnki.net/kcms/detail/21.1581.R.20230828.1448.012.html.DOI:10.12307/2024.419.
LI J L,LUO D S,ZHENG L J,et al. Human osteoarthritic chondrocytes up-regulate the expression of osteoprotegerin in osteoblasts via the Indian hedgehog signaling pathway [J/OL].Chin J Tissue Eng Res,2023:1-8(2023-08-29)[2023-09-03].https://kns.cnki.net/kcms/detail/21.1581.R.20230828.1448.012.htmlhttps://kns.cnki.net/kcms/detail/21.1581.R.20230828.1448.012.html. DOI:10.12307/2024.419http://dx.doi.org/10.12307/2024.419.
申萌萌,刘雁峰. uNK/M-CSF/NO通路与子宫内膜容受性[J]. 中华中医药杂志,2017,32(4):1650-1653.
SHEN M M,LIU Y F. Investigation of uNK/M-CSF/NO pathway and endometial receptivity[J]. China J Tradit Chin Med Pharm,2017,32(4):1650-1653.
陈红梅,王友莲. 破骨细胞在类风湿关节炎致骨破坏病理变化中的作用及其调控[J]. 中国骨质疏松杂志,2016,22(9):1168-1173.
CHEN H M,WANG Y L. Function and regulation of the osteoclast in the pathological changes of bone destruction in rheumatoid arthritis[J]. Chin J Osteoporos,2016,22(9):1168-1173.
周爱萍. 绝经激素治疗骨质疏松症的研究进展[J]. 中国城乡企业卫生,2023,38(6):45-48.
ZHOU A P. Research progress of menopausal hormone therapy for osteoporosis[J]. Chin J Urban Rural Enterp Hyg,2023,38(6):45-48.
王川,祁琳,陈雨萌,等. 大豆苷元对人成骨样MG-63细胞OPG及RANKL表达的调节作用[J]. 中国药理学通报,2021,37(6):803-809.
WANG C,QI L,CHEN Y M,et al. Effect of daidzein on OPG and RANKL expression in human osteoblast-like MG-63 cells[J]. Chin Pharmacol Bull,2021,37(6):803-809.
李硕,王建. 大豆异黄酮临床应用的研究进展[J]. 大豆科学,2020,39(4):633-640.
LI S,WANG J. Research progress on the clinical application of soybean isoflavones[J]. Soybean Sci,2020,39(4):633-640.
LU M N,XIE K G,HUANG K,et al. Effects of soybean isoflavone on metabolism of rat osteoblasts and cytokines in vitro[J]. J Food Sci,2020,85(4):1302-1306.
《中国骨质疏松杂志》骨代谢专家组. 骨代谢生化指标临床应用专家共识:2023修订版[J]. 中国骨质疏松杂志,2023,29(4):469-476.
Bone Metabolism Expert Group of Chinese Journal of Osteoporosis. Expert consensus on clinical application of biochemical indicators of bone metabolism:2023 revision[J]. Chin J Osteoporos,2023,29(4):469-476.
赵瑾凯,应剑,王勇,等. 茶与乳制品中关键成分的相互作用及对健康的影响[J]. 中国食物与营养,2023,29(5):39-44.
ZHAO J K,YING J,WANG Y,et al. Interaction of key ingredients in tea and dairy products and its effects on health[J]. Food Nutr China,2023,29(5):39-44.
邵瑾. 羟基化大豆苷元衍生物的合成及其体外抗氧化活性研究[D]. 兰州:兰州大学,2020.
SHAO J. Synthesis and in vitro antioxidant activity study of hydroxylated of derivatives daidzein[D]. Lanzhou: Lanzhou University,2020.
HORTON J E,RAISZ L G,SIMMONS H A,et al.Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes[J].Science,1972,177(4051):793-795.
石少辉. 去势大鼠胫骨形态计量学改变及骨髓基质细胞IL-1、IL-6、TNF-α、TGF-β mRNA的表达[D]. 天津:天津医科大学,2004.
SHI S H. The changes of histomorphometry of tibia and expression of IL-1,IL-6,TNF-α and TGF-β mRNA on bone marrow stromal cells in ovariectomized rats[D]. Tianjin:Tianjin Medical University,2004.
陈潇. LPS调控破骨相关炎症因子表达及机制探讨[D]. 福州:福建医科大学,2016.
CHEN X. LPS mediate the osteoclastogenesis-related cytokines and mechanism involved[D]. Fuzhou:Fujian Medical University,2016.
李乐飞,金鑫,李程育,等. 大豆苷元抑制人成骨样MG-63细胞分泌IL-6的分子机制研究[J]. 武警后勤学院学报(医学版),2018,27(6):467-471.
LI L F,JIN X,LI C Y,et al. Molecular mechanism of daidzein on inhibiting IL-6 secretion in human osteoblast-like MG-63 cells[J]. J Logist Univ PAP Med Sci,2018,27(6):467-471.
王如梦. 联合法大豆苷元的制备及其生物活性评价[D]. 哈尔滨:哈尔滨商业大学,2020.
WANG R M. Preparation and bioactivity evaluation of aglycone by combined method[D]. Harbin:Harbin University of Commerce,2020.
TANAKA M,FUJII S,INOUE H,et al. (S)-equol is more effective than (R)-equol in inhibiting osteoclast formation and enhancing osteoclast apoptosis,and reduces estrogen deficiency-induced bone loss in mice[J]. J Nutr,2022,152(8):1831-1842.
JIN X,SUN J,YU B,et al. Daidzein stimulates osteoge-nesis facilitating proliferation,differentiation,and antiapoptosis in human osteoblast-like MG-63 cells via estrogen receptor-dependent MEK/ERK and PI3K/Akt activation[J]. Nutr Res,2017,42:20-30.
包蕾,邹世恩,张绍芬. 雌激素受体和过氧化物酶体增殖物激活受体γ介导大豆苷元对骨形成的量效作用[J]. 中西医结合学报,2011,9(2):165-172.
BAO L,ZOU S E,ZHANG S F. Dose-dependent effects of daidzein in regulating bone formation through estrogen receptors and peroxisome proliferator-activated receptor γ[J]. J Chin Integr Med,2011,9(2):165-172.
杨杨,张娜,王如梦,等. 不同剂量大豆苷元对去卵巢大鼠骨质疏松的影响[C]//中国食品科学技术学会第十七届年会摘要集. 西安,2020:162.
YANG Y,ZHANG N,WANG R M,et al. Effects of aglycone at different doses on osteoprosis in ovariectomized rats[C]// Abstracts of the 17th Annual Meeting of CIFST.Xi’an,2020:162.
0
Views
2
下载量
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution