Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier and interfering with ulcerative colitis based on the “thickening intestine” theory

WANG Jinxin; LI Liqun; HUANG Xiaoyan; HUANG Maoguang; LUO Feng; CHEN Yueying; LI Yuling; XIE Sheng; LIU Yuanyuan

doi:10.6039/j.issn.1001-0408.2023.21.18

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Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier and interfering with ulcerative colitis based on the “thickening intestine” theory

更新时间：2023-11-10

- Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier and interfering with ulcerative colitis based on the “thickening intestine” theory
- ZHONGGUO YAOFANG Vol. 34, Issue 21, Pages: 2671-2677(2023)
- 作者机构：
  
  1.广西中医药大学研究生学院，南宁　530001
  2.广西中医药大学第一附属医院脾胃病科二区，南宁　530023
  3.广西中医药大学第一附属医院中医治未病中心，南宁　530023
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.21.18
  CLC： R285;R965
- Published：15 November 2023，
  
  Received：04 April 2023，
  
  Revised：18 August 2023，
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王金鑫,黎丽群,黄晓燕等.基于“厚肠”理论的中医药调控黏液屏障干预溃疡性结肠炎的机制研究进展 ^Δ[J].中国药房,2023,34(21):2671-2677.

WANG Jinxin,LI Liqun,HUANG Xiaoyan,et al.Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier and interfering with ulcerative colitis based on the “thickening intestine” theory[J].ZHONGGUO YAOFANG,2023,34(21):2671-2677.
王金鑫,黎丽群,黄晓燕等.基于“厚肠”理论的中医药调控黏液屏障干预溃疡性结肠炎的机制研究进展 ^Δ[J].中国药房,2023,34(21):2671-2677. DOI： 10.6039/j.issn.1001-0408.2023.21.18.

WANG Jinxin,LI Liqun,HUANG Xiaoyan,et al.Research advance in the mechanism exploration of traditional Chinese medicine regulating mucus barrier and interfering with ulcerative colitis based on the “thickening intestine” theory[J].ZHONGGUO YAOFANG,2023,34(21):2671-2677. DOI： 10.6039/j.issn.1001-0408.2023.21.18.

摘要

溃疡性结肠炎（UC）是临床慢性肠道病变，肠上皮黏液屏障受损是该病的重要病理机制。黏蛋白2（MUC2）是肠道黏液屏障的主要组成部分，而杯状细胞是分泌MUC2的“主力军”，可维持和更新肠黏液层，保证其完整性。因此，通过促进杯状细胞合成MUC2从而修复肠道黏液屏障，是治疗UC的重要策略。中医学者认为肠道中存在一层固有的“脂膜”或“脂膏”，湿热等病理因素导致该结构变薄，是“腹泻”“肠澼”发生的根本病机，这与现代医学中肠道黏液屏障受损导致UC不谋而合。本文通过总结中药复方或中药活性成分调控肠道黏液屏障干预UC的作用机制发现，黄连解毒汤、芍药汤、复方苦参汤等中药复方以及苍术挥发油、芍药苷、木瓜三萜等中药活性成分可通过促进杯状细胞合成分泌功能，达到“厚肠”的目的，进而改善UC症状。

Abstract

Ulcerative colitis （UC） is a clinical chronic intestinal disease， and the damage of the intestinal epithelial mucus barrier is an important pathological mechanism of UC. Mucin 2 （MUC2） is a major component of the intestinal mucus barrier， and goblet cells are the “main force” of MUC2 secretion， maintaining and renewing the intestinal mucus layer to ensure its integrity. Therefore， repairing the intestinal mucus barrier by promoting the synthesis of MUC2 by goblet cells is an important strategy for the treatment of UC. Traditional Chinese medicine scholars believe that there is an inherent layer of “lipid membrane” or “fat paste” in the intestine， and pathological factors such as moisture and heat lead to the thinning of this structure， which is the fundamental pathogenesis of “diarrhea” and “intestinal dysentery”. It coincides with the damage of intestinal mucus barrier leading to UC in modern medicine. Based on this， this paper summarized the mechanism of Chinese herbal compounds or Chinese herbal active components in regulating intestinal mucus barrier to interfere with UC. It was found that Chinese herbal compounds such as Huanglian jiedu decoction， Shaoyao decoction and Compound Kusen decoction， as well as Chinese herbal active ingredients such as volatile oil of

Atractylodes lancea

， paeoniflorin and papaya triterpenes could promote the synthesis and secretion function of goblet cells， and achieve the purpose of “thickening intestine”， thus relieving UC symptoms.

关键词

中医药溃疡性结肠炎黏蛋白2杯状细胞肠道黏液屏障

Keywords

ulcerative colitismucin 2goblet cellintestinal mucus barrier

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