ZHU Jing,XIE Ji,ZHAO Ziting,et al.Meta-analysis of efficacy and safety of cabozantinib in the treatment of advanced thyroid cancer[J].ZHONGGUO YAOFANG,2023,34(22):2800-2804.
ZHU Jing,XIE Ji,ZHAO Ziting,et al.Meta-analysis of efficacy and safety of cabozantinib in the treatment of advanced thyroid cancer[J].ZHONGGUO YAOFANG,2023,34(22):2800-2804. DOI: 10.6039/j.issn.1001-0408.2023.22.20.
Meta-analysis of efficacy and safety of cabozantinib in the treatment of advanced thyroid cancer
To review the efficacy and safety of cabozantinib in the treatment of advanced thyroid cancer.
METHODS
2
Retrieved from PubMed, the Cochrane Library, Embase, ClinicalTrials.gov, Wanfang data, VIP, CNKI and China Clinical Trials Registry, randomized controlled trials (RCTs) about cabozantinib (trial group) versus placebo (control group) were collected from the inception to Nov. 2022. After literature screening, data extraction and quality evaluation, meta-analysis was performed by using RevMan 5.4 software.
RESULTS
2
A total of 4 RCTs were included involving 588 patients. The results of the meta-analysis showed that the progression free survival (PFS) [HR=0.24, 95%CI (0.19,0.31),
<0.000 01], and hypertension [RR=6.50,95%CI (3.90,10.83),
P
<0.000 01] in trial group were significantly higher than control group; there was no statistical significance in overall survival (OS) [HR=0.83,95%CI (0.67,1.02),
P
=0.07] or the incidence of fatigue [RR=1.25,95%CI (0.78,1.98),
P
=0.35] between the two groups. Subgroup analysis showed that PFS and ORR in patients with differentiated thyroid carcinoma (DTC) and medullary thyroid carcinoma (MTC) in the trial group were significantly higher than control group (
P
<0.05). There was no significant difference in OS of DTC and MTC patients in the trial group compared with the control group (
P
>0.05).
CONCLUSIONS
2
Cabozantinib can prolong PFS and increase ORR in patients with advanced thyroid cancer, but the incidence of AE is high.
关键词
卡博替尼甲状腺癌有效性安全性Meta分析
Keywords
thyroid cancerefficacysafetymeta-analysis
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