Research progress on anti-pulmonary fibrosis effect and mechanism of flavonoids

WANG Yiting; PENG Weiwen; WANG Zhuqiang; HUANG Liting

doi:10.6039/j.issn.1001-0408.2023.23.22

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Research progress on anti-pulmonary fibrosis effect and mechanism of flavonoids

更新时间：2023-12-08

- Research progress on anti-pulmonary fibrosis effect and mechanism of flavonoids
- ZHONGGUO YAOFANG Vol. 34, Issue 23, Pages: 2939-2944(2023)
- 作者机构：
  
  广州中医药大学附属中山中医院，广东中山　528400
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2023.23.22
  CLC： R965
- Published：15 December 2023，
  
  Received：19 April 2023，
  
  Revised：12 November 2023，
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王依婷,彭伟文,王珠强等.黄酮类成分抗肺纤维化的作用机制研究进展 ^Δ[J].中国药房,2023,34(23):2939-2944.

WANG Yiting,PENG Weiwen,WANG Zhuqiang,et al.Research progress on anti-pulmonary fibrosis effect and mechanism of flavonoids[J].ZHONGGUO YAOFANG,2023,34(23):2939-2944.
王依婷,彭伟文,王珠强等.黄酮类成分抗肺纤维化的作用机制研究进展 ^Δ[J].中国药房,2023,34(23):2939-2944. DOI： 10.6039/j.issn.1001-0408.2023.23.22.

WANG Yiting,PENG Weiwen,WANG Zhuqiang,et al.Research progress on anti-pulmonary fibrosis effect and mechanism of flavonoids[J].ZHONGGUO YAOFANG,2023,34(23):2939-2944. DOI： 10.6039/j.issn.1001-0408.2023.23.22.

摘要

肺纤维化是以成纤维细胞增殖及大量细胞外基质聚集并伴炎症损伤、组织结构破坏为特征的一大类肺疾病的终末期表现。研究表明，黄酮类成分具有抗肺纤维化的作用，其中二氢杨梅素、桑色素、漆黄素等可通过抑制成纤维细胞分化，阿尔泰金莲花总黄酮、橘皮苷、蒙花苷等可通过发挥抗炎作用，黄芩总黄酮、黄芩苷、白杨素等可通过抑制上皮-间充质转化，荔枝核总黄酮、地奥司明、水飞蓟宾等可通过抑制氧化应激，槲皮素、黄芩苷、芹菜素等可通过调控自噬，镰形棘豆总黄酮、毛蕊异黄酮、二氢槲皮素等可通过调控细胞凋亡过程，柚皮素、黄芩苷、香草兰总黄酮等可通过抑制细胞焦亡等多种途径，发挥抗肺纤维化的作用。

Abstract

Pulmonary fibrosis is the end-stage manifestation of a large class of lung diseases characterized by fibroblast proliferation and accumulation of a large amount of extracellular matrix accompanied by inflammatory injury and tissue structure destruction. Studies have shown that flavonoids have anti-pulmonary fibrosis effects through multiple paths， including dihydromyricetin， morin and fisetin can inhibit fibroblast differentiation；

Trollius altaicus

flavonoids， hesperidin and linarin can play an anti-inflammatory role； total flavonoids from

Scutellaria baicalensis，

scutellarin and chrysin can inhibit epithelial-mesenchymal transition； total flavonoids of

Litchi chinensis，

diosmin

and silybin can play an anti-oxidative stress role； quercetin， baicalin and apigenin can regulate autophagy； total flavonoids of

Oxytropis falcata，

calycosin and dihydroquercetin can regulate apoptosis； naringin， scutellarin and total flavonoids of

Dracocephalum moldavica

can inhibit pyroptosis， thus exerting anti-pulmonary fibrosis effects.

关键词

黄酮类成分肺纤维化作用机制

Keywords

pulmonary fibrosismechanism

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