LIU Shuang,CHEN Hongsheng,GUO Qi,et al.Investigation of patients’ preferences regarding therapeutic drug monitoring of mycophenolic acid in solid organ transplantation[J].ZHONGGUO YAOFANG,2024,35(01):90-94.
LIU Shuang,CHEN Hongsheng,GUO Qi,et al.Investigation of patients’ preferences regarding therapeutic drug monitoring of mycophenolic acid in solid organ transplantation[J].ZHONGGUO YAOFANG,2024,35(01):90-94. DOI: 10.6039/j.issn.1001-0408.2024.01.16.
Investigation of patients’ preferences regarding therapeutic drug monitoring of mycophenolic acid in solid organ transplantation
共收集到有效问卷140份,有效回收率为77.35%。140例患者接受MPA TDM的平均意愿得分为(4.01±0.65)分,表明总体意愿值较高;有116例(82.86%)患者表示愿意或非常愿意接受MPA TDM;既往接受过TDM与未接受过TDM患者的意愿得分差异有统计学意义[(4.30±0.53)分 vs. (3.80±0.65)分,
To investigate the preferences of patients who underwent solid organ transplantation regarding therapeutic drug monitoring (TDM) of mycophenolic acid (MPA) and explore the factors influencing patients’ decision-making process, so as to provide support for the development of individualized medication guidelines for MPA and improvement of clinical decision-making.
METHODS
2
The cross-sectional study was used to design the questionnaire on the patients’ preferences to accept MPA TDM, and involved patients who underwent solid organ transplantation and received MPA treatment at two tertiary hospitals in Beijing from April 14, 2022, to June 27, 2022. The Likert 5-level scoring method was used to score the patients’ preferences to accept MPA TDM, the influencing factors and their correlation of the patients’ preferences to accept MPA TDM were analyzed by Pearson correlation analysis and binary Logistic regression analysis, and the nonparametric test and chi-square test were used to rank and analyze the consistency of the factors affecting patients’ preference decision.
RESULTS
2
A total of 140 questionnaires were collected, and the effective recovery rate was 77.35%. The average preference score of 140 patients to receive MPA TDM was (4.01±0.65), and the overall preference value was high. There were 116 (82.86%) patients agreed or strongly agreed with MPA TDM. Significant differences were observed in preference scores between patients who had previously undergone MPA TDM and those who had never undergone it [(4.30±0.53) scores vs. (3.80±0.65) scores,
P
<0.001]. Additionally, patients’ preference scores were significantly influenced by their understanding level and attention level (
P
<0.001). The ranking of factors contributing to decision-making exhibited consistency (
P
<0.001). The factors were ranked in descending order of clinical efficacy, safety, comfortability, economy and time cost.
CONCLUSIONS
2
The patients who underwent solid organ transplantation hold high preferences towards MPA TDM. The primary factors influencing their decisions are their prior experience, understanding level, and attention level.
关键词
霉酚酸类药物治疗药物监测患者意愿实体器官移植问卷调查
Keywords
therapeutic drug monitoringpatient’s preferencessolid organ transplantationquestionnaire survey
references
NELSON J,ALVEY N,BOWMAN L,et al. Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation:endorsed by the American College of Clinical Pharmacy,American Society of Transplantation,and the International Society for Heart and Lung Transplantation[J]. Pharmacotherapy,2022,42(8):599-633.
LENTINE K L,SMITH J M,MILLER J M,et al. OPTN/SRTR 2021 annual data report:kidney[J]. Am J Transplant,2023,23(2 Suppl 1):S21-S120.
COLVIN M M,SMITH J M,AHN Y S,et al. OPTN/SRTR 2021 annual data report:heart[J]. Am J Transplant,2023,23(2 Suppl 1):S300-S378.
KWONG A J,EBEL N H,KIM W R,et al. OPTN/SRTR 2021 annual data report:liver[J]. Am J Transplant,2023,23(2 Suppl 1):S178-S263.
VALAPOUR M,LEHR C J,SCHLADT D P,et al. OPTN/SRTR 2021 annual data report:lung[J]. Am J Transplant,2023,23(2 Suppl 1):S379-S442.
BERGAN S,BRUNET M,HESSELINK D A,et al. Personalized therapy for mycophenolate:consensus report by the International Association of Therapeutic Drug Monito- ring and Clinical Toxicology[J]. Ther Drug Monit,2021,43(2):150-200.
DJULBEGOVIC B,GUYATT G H. Progress in evidence-based medicine:a quarter century on[J]. Lancet,2017,390(10092):415-423.
Institute of Medicine (US) Committee on Standards for Developing Trustworthy Clinical Practice Guidelines,GRAHAM R,MANCHER M,et al. Clinical practice guidelines we can trust[M]. Washington (DC):National Academies Press (US),2011:1-290.
BAI F,LING J,ESOIMEME G,et al. A systematic review of questionnaires about patient’s values and prefe- rences in clinical practice guidelines[J]. Patient Prefer Adherence,2018,12:2309-2323.
BASTEMEIJER C M,VOOGT L,VAN EWIJK J P,et al. What do patient values and preferences mean? A taxo- nomy based on a systematic review of qualitative papers[J]. Patient Educ Couns,2017,100(5):871-881.
RONG Y,PATEL V,KIANG T K L. Recent lessons learned from population pharmacokinetic studies of mycophenolic acid:physiological,genomic,and drug interactions leading to the prediction of drug effects[J]. Expert Opin Drug Metab Toxicol,2021,17(12):1369-1406.
LIU S,ZHANG E Y,SONG Z W,et al. Systematic review and meta-analysis on the necessity of therapeutic drug monitoring of mycophenolic acid[J]. Chin J Hosp Pharm,2021,41(5):495-501,511.
DOWNING H J,PIRMOHAMED M,BERESFORD M W,et al. Paediatric use of mycophenolate mofetil[J]. Br J Clin Pharmacol,2013,75(1):45-59.
CAI M Y,ZHOU L,GAO D H,et al. A national survey of individualized pharmaceutical care practice in Chinese hospitals in 2019[J]. Front Pharmacol,2023,14:1022134.
YIN T,LIANG H Y,HUANG Q,et al. A survey of therapeutic drug monitoring status in China[J]. Ther Drug Monit,2023,45(2):151-158.
LIU S,ZHANG E Y,YI Z M,et al. Analysis for the current status of mycophenolic acid therapeutic drug monito- ring in China[J]. Chin J Clin Pharmacol,2021,37(3):308-311.
ZENG L N,YI Q S,HUANG L,et al. The guideline for therapeutic drug monitoring guidelines development[J]. J Evid Based Med,2022,15(3):272-283.
SERRANO-AGUILAR P,TRUJILLO-MARTIN M D E L M,PÉREZ DE LA ROSA A,et al. Patient participation in a clinical guideline development for systemic lupus erythematosus[J]. Patient Educ Couns,2015,98(9):1156-1163.
YE Z K,REINTAM BLASER A,LYTVYN L,et al. Gastrointestinal bleeding prophylaxis for critically ill patients:a clinical practice guideline[J]. BMJ,2020,368:16722.
Study on the present situation of narcotic drugs equipment and management in 251 primary healthcare institutions from Qiandongnan prefecture
临床药理学中以问题为基础的教学模式的探索与实践
社区药学服务对高血压患者认知行为的影响的调查分析
Evaluation of the rationality and feasibility of the grouping method for centralized procurement of insulin drugs in Wuhan based on the results of questionnaire survey among endocrinology physicians
Investigation and Analysis of the Implementation Status and Effect of Electronic Prescription and Remote Pharma- ceutical Care in Social Pharmacy from the Perspective of Consumers
Related Author
HAN Minzhen
ZHANG Zhenzhu
XIA Jie
LIU Yang
HU Hanshuai
WANG Jinxingyi
龙锐 张成志 朱深银 周远大 邱峰 陈庆宪 李娟
邹殿明 洪惠
Related Institution
Dept. of Pharmacy, the Second Affiliated Hospital of Guizhou Medical University, Guizhou Kaili