Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury

JIA Suxia; XU Xiaomin; YANG Huicong; LIU Shumin

doi:10.6039/j.issn.1001-0408.2024.01.22

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Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury

更新时间：2024-01-11

- Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury
- ZHONGGUO YAOFANG Vol. 35, Issue 1, Pages: 124-128(2024)
- 作者机构：
  
  黑龙江中医药大学中医药研究院，哈尔滨　150040
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.01.22
  CLC： R965;R285.5
- Published：15 January 2024，
  
  Received：28 June 2023，
  
  Revised：11 November 2023，
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贾素霞,徐晓敏,杨慧聪等.中药调控Nrf2/HO-1信号通路干预心肌缺血再灌注损伤的研究进展 ^Δ[J].中国药房,2024,35(01):124-128.

JIA Suxia,XU Xiaomin,YANG Huicong,et al.Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury[J].ZHONGGUO YAOFANG,2024,35(01):124-128.
贾素霞,徐晓敏,杨慧聪等.中药调控Nrf2/HO-1信号通路干预心肌缺血再灌注损伤的研究进展 ^Δ[J].中国药房,2024,35(01):124-128. DOI： 10.6039/j.issn.1001-0408.2024.01.22.

JIA Suxia,XU Xiaomin,YANG Huicong,et al.Research progress of traditional Chinese medicine in regulating Nrf2/HO-1 signaling pathway to interfere with myocardial ischemia-reperfusion injury[J].ZHONGGUO YAOFANG,2024,35(01):124-128. DOI： 10.6039/j.issn.1001-0408.2024.01.22.

摘要

心肌缺血再灌注损伤（MIRI）是心肌梗死患者进行血运重建时的严重并发症。核转录因子红系2相关因子2（Nrf2）/血红素加氧酶1（HO-1）信号通路在MIRI病理进程中具有重要意义。目前研究发现，中药对缺血再灌注引起的心肌损伤具有很好的效果。本文基于Nrf2/HO-1信号通路总结中药复方和单体干预MIRI的作用机制，发现中药复方（益心方、温阳通脉方、定心方Ⅰ号方）以及中药单体萜类（银杏内酯、黄芪甲苷、人参皂苷等）、酚类（巴西苏木素、苏木酮A、白藜芦醇等）、醌类（芦荟素、大黄素）等均可通过激活Nrf2/HO-1信号通路，抑制氧化应激、炎症反应等，从而减轻MIRI。

Abstract

Myocardial ischemia-reperfusion injury （MIRI） is a serious complication of revascularization in patients with myocardial infarction. The nuclear factor erythroid 2-related factor 2 （Nrf2）/heme oxygenase-1 （HO-1） signaling pathway plays an important role in the pathological process of MIRI. Currently，research has found that traditional Chinese medicine has a good effect on myocardial injury caused by ischemia-reperfusion. Based on the Nrf2/HO-1 signaling pathway，this article summarizes the action mechanism of traditional Chinese medicine formulas and monomers in intervening with MIRI. It is found that traditional Chinese medicine formulas （Yixin formula，Wenyang tongmai formula，Dingxin formula Ⅰ），monomers such as terpenoids （ginkgolides，astragaloside Ⅳ，ginsenosides），phenols （brazilin，hematoxylin A，resveratrol） and quinones （aloe，emodin） can alleviate MIRI by activating the Nrf2/HO-1 signaling pathway，inhibiting oxidative stress and inflammatory reactions，etc.

关键词

中药心肌缺血再灌注损伤核转录因子红系2相关因子2血红素加氧酶1信号通路

Keywords

myocardial ischemia-reperfusion injurynuclear factor erythroid 2-related factor 2heme oxygenase-1signaling pathway

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