Research progress about traditional Chinese medicine in the intervention of gastric cancer by regulating Th17/Treg balance

YIN Jiaqi; LI Liqun; XIE Sheng

doi:10.6039/j.issn.1001-0408.2024.03.20

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Research progress about traditional Chinese medicine in the intervention of gastric cancer by regulating Th17/Treg balance

更新时间：2024-02-07

- Research progress about traditional Chinese medicine in the intervention of gastric cancer by regulating Th17/Treg balance
- ZHONGGUO YAOFANG Vol. 35, Issue 3, Pages: 379-384(2024)
- 作者机构：
  
  1.广西中医药大学研究生学院，南宁　530001
  2.广西中医药大学第一附属医院脾胃病科，南宁　530001
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.03.20
  CLC： R285
- Published：15 February 2024，
  
  Received：03 July 2023，
  
  Revised：15 December 2023，
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尹嘉琪,黎丽群,谢胜.中药通过调节Th17/Treg平衡干预胃癌的研究进展 ^Δ[J].中国药房,2024,35(03):379-384.

YIN Jiaqi,LI Liqun,XIE Sheng.Research progress about traditional Chinese medicine in the intervention of gastric cancer by regulating Th17/Treg balance[J].ZHONGGUO YAOFANG,2024,35(03):379-384.
尹嘉琪,黎丽群,谢胜.中药通过调节Th17/Treg平衡干预胃癌的研究进展 ^Δ[J].中国药房,2024,35(03):379-384. DOI： 10.6039/j.issn.1001-0408.2024.03.20.

YIN Jiaqi,LI Liqun,XIE Sheng.Research progress about traditional Chinese medicine in the intervention of gastric cancer by regulating Th17/Treg balance[J].ZHONGGUO YAOFANG,2024,35(03):379-384. DOI： 10.6039/j.issn.1001-0408.2024.03.20.

摘要

胃癌（GC）是一种较为常见的消化道恶性肿瘤。辅助性T细胞17（Th17）和调节性T细胞（Treg）是CD4

T细胞的分化亚群，Th17/Treg的失衡已被证实与GC的发病进程密切相关。中药不仅可改善GC患者的生存预后，而且在GC的术后化疗中起到了增效减毒的效果。本文系统整理了中药通过调节Th17/Treg平衡干预GC的作用规律。结果发现，中药复方可通过发挥健脾益气、健脾温阳、化瘀解毒等功效以调节GC的Th17/Treg平衡；中药及其有效成分通过调节Th17/Treg平衡来干预GC的作用机制主要表现为抑制Th17、Treg的过度分化及其转录因子、细胞因子的过度表达，逆转GC Th17/Treg平衡向Th17或Treg的过度漂移，从而恢复GC Th17/Treg的免疫平衡。

Abstract

Gastric cancer （GC） is a common malignant tumor of the digestive tract. T helper cells 17 （Th17） and T regulatory cells （Treg） are differentiated subsets of CD4

T cells. Th17/Treg imbalance has been shown to be closely related to the progression of GC. Traditional Chinese medicine （TCM） can not only improve the survival prognosis of GC patients， but also play a role in enhancing the efficacy and reducing the toxicity of postoperative chemotherapy for GC. This paper systematically sorted out the action rules of TCM in the intervention of GC by regulating Th17/Treg balance. The results showed that the TCM compound could regulate the balance of GC Th17/Treg by invigorating the spleen and invigorating Qi， warming Yang， removing blood stasis and detoxifying. The mechanism of regulating Th17/Treg balance in the intervention of GC is mainly to inhibit the excessive differentiation of Th17 and Treg and the overexpression of transcription factors and cytokines， reverse the excessive drift of GC Th17/Treg balance to Th17 or Treg， and thus restore the immune balance of GC Th17/Treg.

关键词

中药胃癌辅助性T细胞17调节性T细胞免疫平衡临床疗效作用机制

Keywords

gastric cancerT helper cell 17T regulatory cellsimmune balanceclinical effectmechanism of action

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