Effects of esketamine for multimodal analgesia on opioid consumption and gastric motility in mechanically ventilated non-surgical ICU patients

LONG Yi; LIU Qian; LI Rui; WU Guixin; HE Aiting; JIANG Zhengying

doi:10.6039/j.issn.1001-0408.2024.04.16

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Effects of esketamine for multimodal analgesia on opioid consumption and gastric motility in mechanically ventilated non-surgical ICU patients

更新时间：2024-02-23

- Effects of esketamine for multimodal analgesia on opioid consumption and gastric motility in mechanically ventilated non-surgical ICU patients
- ZHONGGUO YAOFANG Vol. 35, Issue 4, Pages: 468-471(2024)
- 作者机构：
  
  重庆大学附属肿瘤医院重症医学科，重庆　400030
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.04.16
  CLC： R971+.3;R614.2
- Published：29 February 2024，
  
  Received：14 August 2023，
  
  Revised：28 January 2024，
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隆毅,刘倩,李蕊等.艾司氯胺酮多模式镇痛对ICU机械通气非手术患者阿片类药物用量和胃运动功能的影响 ^Δ[J].中国药房,2024,35(04):468-471.

LONG Yi,LIU Qian,LI Rui,et al.Effects of esketamine for multimodal analgesia on opioid consumption and gastric motility in mechanically ventilated non-surgical ICU patients[J].ZHONGGUO YAOFANG,2024,35(04):468-471.
隆毅,刘倩,李蕊等.艾司氯胺酮多模式镇痛对ICU机械通气非手术患者阿片类药物用量和胃运动功能的影响 ^Δ[J].中国药房,2024,35(04):468-471. DOI： 10.6039/j.issn.1001-0408.2024.04.16.

LONG Yi,LIU Qian,LI Rui,et al.Effects of esketamine for multimodal analgesia on opioid consumption and gastric motility in mechanically ventilated non-surgical ICU patients[J].ZHONGGUO YAOFANG,2024,35(04):468-471. DOI： 10.6039/j.issn.1001-0408.2024.04.16.

摘要

目的

探讨艾司氯胺酮多模式镇痛对重症监护病房（ICU）机械通气非手术患者阿片类药物用量和胃运动功能的影响。

方法

选择我院2023年2月1日至7月31日ICU机械通气非手术患者40例，使用信封法随机分为对照组和艾司氯胺酮（S-K）组，每组20例患者。对照组患者给予舒芬太尼，S-K组患者恒速输注盐酸艾司氯胺酮注射液0.2 mg/（kg·h）+舒芬太尼。比较两组患者的治疗期长度、镇痛达标率、镇静水平、镇痛镇静药物使用量及胃运动功能指标。

结果

两组患者的治疗期长度、镇痛达标率、镇静水平、丙泊酚和咪达唑仑使用量比较，差异均无统计学意义（

＞0.05）。S-K组患者舒芬太尼使用量显著小于对照组（

＜0.05）。与随机分组后1 h比较，S-K组患者随机分组后72 h的胃窦收缩频率、胃窦收缩幅度、胃窦运动指数均显著提高，且显著高于对照组（

＜0.05）。

结论

艾司氯胺酮可在保证镇痛、镇静水平的同时，降低ICU机械通气非手术患者的阿片类药物使用量，改善胃运动功能。

Abstract

OBJECTIVE

To investigate the effects of esketamine for multimodal analgesia on opioid consumption and gastric motility in mechanically ventilated non-surgical intensive care unit （ICU） patients.

METHODS

Forty cases of mechanically ventilated non-surgical patients in the ICU of our hospital from February 1st， 2023 to July 31st， 2023 were selected and randomly divided into control group and esketamine （S-K） group using grouping method with opaque envelopes， with 20 cases in each group. Control group was given sufentanil， and S-K group was infused with Esketamine hydrochloride injection at a constant rate of 0.2 mg/（kg·h）+ sufentanil. The treatment period length， analgesic compliance rate， sedation level， analgesic and sedative consumption， and gastric motility indexes were compared between the two groups.

RESULTS

There was no statistically significant difference in the treatment period length， analgesic compliance rate， sedation level， or the consumption of propofol and midazolam between the two groups （

＞0.05）. The consumption of sufentanil in the S-K group was significantly less than control group （

＜0.05）. Compared with 1 h after randomization， the antral contraction frequency， antral contraction amplitude and antral motility index of patients in the S-K group were significantly higher at 72 h after randomization and were significantly higher than control group （

＜0.05）.

CONCLUSIONS

Esketamine may reduce opioid consumption and improve gastric motility in mechanically ventilated non-surgical ICU patients while ensuring a level of analgesic sedation.

关键词

艾司氯胺酮多模式镇痛机械通气重症监护病房胃运动功能

Keywords

multimodal analgesiamechanical ventilationintensive care unitgastric motility

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