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Research progress of traditional Chinese medicine monomer and compound intervention on the Wnt signaling pathway in regulating bone metabolism
- ZHONGGUO YAOFANG Vol. 35, Issue 5, Pages: 623-628(2024)
- 作者机构：
1.重庆医科大学药学院，重庆 400016
2.重庆中医药学院附属第一医院/重庆市中医院药剂科，重庆 400021
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2024.05.20
CLC： R285.5Published：15 March 2024，
Received：16 September 2023，
Revised：21 January 2024，
扫 描 看 全 文
李婷,张小琼,刘梅等.中药单体及复方干预Wnt信号通路调控骨代谢的研究进展 Δ[J].中国药房,2024,35(05):623-628.
LI Ting,ZHANG Xiaoqiong,LIU Mei,et al.Research progress of traditional Chinese medicine monomer and compound intervention on the Wnt signaling pathway in regulating bone metabolism[J].ZHONGGUO YAOFANG,2024,35(05):623-628.
李婷,张小琼,刘梅等.中药单体及复方干预Wnt信号通路调控骨代谢的研究进展 Δ[J].中国药房,2024,35(05):623-628. DOI： 10.6039/j.issn.1001-0408.2024.05.20.
LI Ting,ZHANG Xiaoqiong,LIU Mei,et al.Research progress of traditional Chinese medicine monomer and compound intervention on the Wnt signaling pathway in regulating bone metabolism[J].ZHONGGUO YAOFANG,2024,35(05):623-628. DOI： 10.6039/j.issn.1001-0408.2024.05.20.
摘要
骨代谢是指骨骼重塑过程中发生的分解合成代谢，其平衡由骨吸收和骨形成调控。这种平衡稍有偏差就会导致各种骨骼疾病，如骨质疏松症、肾性骨病等。中药单体和复方在治疗骨代谢疾病方面具有一定优势。Wnt信号通路包括依赖
β
-连环蛋白（
β
-catenin）的经典Wnt信号通路和不依赖
β
-catenin的非经典Wnt信号通路，且2种通路均可通过调控骨形成和骨吸收来维持骨代谢平衡，对骨骼发育、骨量维持和骨重塑至关重要。近年来，多种中药单体（如芍药内酯苷、梓醇、淫羊藿苷）以及中药复方（如左归丸、益肾固骨方、杜仲健骨方等）被证实可通过激活Wnt信号通路，促进骨髓间充质干细胞成骨分化、成骨细胞增殖和分化来修复骨损伤和治疗骨质疏松症。基于此，本文总结了中药单体及复方干预Wnt信号通路调控骨代谢的研究进展，以期为中药防治骨代谢疾病的临床应用及新药研发提供思路。
Abstract
Bone metabolism refers to the decomposition and anabolism occurring during bone remodeling， and its balance is regulated by bone resorption and bone formation. A slight deviation of this balance causes various skeletal diseases， such as osteoporosis and renal osteodystrophy. Traditional Chinese medicine （TCM） monomers and compounds have certain advantages in treating bone metabolism diseases. The Wnt signaling pathway includes the canonical Wnt signaling pathway， dependent on
β
-catenin， and the non-canonical Wnt signaling pathway， independent of
β
-catenin. Both types of pathways can maintain bone metabolism balance by regulating bone formation and bone resorption and are essential for bone development， bone mass maintenance， and bone remodeling. A variety of TCM monomers （albiflorin， catalpol and icariin） and formulas （Zuogui pill， Yishen gugu prescription， Duzhong jiangu prescription， etc.） have been confirmed to promote differentiation of bone marrow mesenchymal stem cells， proliferation and differentiation of osteoblasts， bone injury repair， and osteoporosis improvement by activating the Wnt signaling pathway in recent years. Here， this article summarizes the research progress in the Wnt signaling pathway regulation of bone metabolism by TCM monomers and compounds to provide ideas for the clinical application of TCM and the research and development of new drugs for the prevention and treatment of bone metabolism diseases.
关键词
中药单体中药复方骨代谢Wnt信号通路骨形成骨吸收
Keywords
traditional Chinese medicine compoundbone metabolismWnt signaling pathwaybone formationbone resorption
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