Research progress of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing

YANG Chaoqiang; WANG Xiaomin; WANG Liang; WANG Yican; KANG Tiantai; YANG Qing; SHU Hongxu; YANG Yunyun; ZHANG Hulin

doi:10.6039/j.issn.1001-0408.2024.06.23

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Research progress of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing

更新时间：2024-04-09

- Research progress of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing
  增强出版
- ZHONGGUO YAOFANG Vol. 35, Issue 6, Pages: 767-772(2024)
- 作者机构：
  
  1.甘肃中医药大学中医临床学院，兰州　730030
  2.甘肃中医药大学附属医院北院骨科，兰州　730030
  3.甘肃省中心医院骨科，兰州　730070
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.06.23
  CLC： R96;R285;R274.9
- Published：30 March 2024，
  
  Received：03 July 2023，
  
  Revised：31 January 2024，
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杨超强,汪小敏,王亮等.中药调控相关信号通路促进腱骨愈合的研究进展 ^Δ[J].中国药房,2024,35(06):767-772.

YANG Chaoqiang,WANG Xiaomin,WANG Liang,et al.Research progress of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing[J].ZHONGGUO YAOFANG,2024,35(06):767-772.
杨超强,汪小敏,王亮等.中药调控相关信号通路促进腱骨愈合的研究进展 ^Δ[J].中国药房,2024,35(06):767-772. DOI： 10.6039/j.issn.1001-0408.2024.06.23.

YANG Chaoqiang,WANG Xiaomin,WANG Liang,et al.Research progress of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing[J].ZHONGGUO YAOFANG,2024,35(06):767-772. DOI： 10.6039/j.issn.1001-0408.2024.06.23.

摘要

腱骨愈合是一种复杂的生物学过程，多条信号通路参与其中，如转化生长因子β信号通路、骨形态发生蛋白信号通路、Wnt信号通路、成纤维细胞生长因子信号通路、核因子κB信号通路等。本文总结了中药调控相关信号通路促进腱骨愈合的研究现状，发现多种中药单体或提取物（如黄芩素、淫羊藿苷、骨碎补总黄酮、小白菊内酯、三七总皂苷等）及中药复方（如桃红四物汤、六味地黄丸、续筋接骨液等）能够通过调节以上信号通路促进骨形成、抗炎、抗氧化等，进而有效促进腱骨愈合。

Abstract

Tendon-bone healing is a complex biological process. Multiple signaling pathways are involved in tendon-bone healing， including transforming growth factor-β signaling pathway， bone morphogenetic protein signaling pathway， Wnt signaling pathway， fibroblast growth factor signaling pathway and nuclear transcription factor-κB signaling pathway. This paper summarizes the research status of traditional Chinese medicine regulating related signaling pathways to promote tendon-bone healing. It is found that a variety of traditional Chinese medicine monomers or herbal extracts （such as baicalein， icariin， total flavonoids of

Drynaria fortunei

， parthenolide， total saponins of

Panax notoginseng

， etc.） and traditional Chinese medicine compounds （such as Taohong siwu decoction， Liuwei dihuang pill， Xujin jiegu liquid， etc.） can promote bone formation， anti-inflammatory， anti-oxidation， by regulating the above signaling pathways， thereby effectively promoting tendon-bone healing.

关键词

中药腱骨愈合信号通路作用机制

Keywords

tendon-bone healingsignal pathwaymechanism of action

references

谢求恩，易启鹏，王鹏，等. 淫羊藿苷-透明质酸对兔肩袖腱骨愈合的影响及机制研究[J]. 现代中西医结合杂志，2023，32（3）：320-325.

XIE Q E，YI Q P，WANG P，et al. Effect of epimedium-hyaluronic acid on the healing of rotator cuff tendon bone in rabbits and its mechanism[J]. Mod J Integr Tradit Chin West Med，2023，32（3）：320-325.

廖昊燃，余伟林，胡庆翔，等. 生物学方法促进肩袖腱骨愈合研究进展[J]. 中华肩肘外科电子杂志，2021，7（2）：183-186.

LIAO H R，YU W L，HU Q X，et al. Research progress of biological methods in promoting rotator cuff tendon-bone healing[J]. Chin J Shoulder Elb Electron Ed，2021，7（2）：183-186.

孙畅，郭亭，李林涛，等. 前交叉韧带重建术后腱骨愈合的生物学干预研究进展[J]. 中华骨与关节外科杂志，2020，13（10）：863-869.

SUN C，GUO T，LI L T，et al. Research progress of biological intervention on tendon-bone healing after anterior cruciate ligament reconstruction[J]. Chin J Bone Jt Surg，2020，13（10）：863-869.

杨超强，汪小敏，王亮，等. 间充质干细胞促进腱骨愈合的机制研究进展[J]. 中国中医骨伤科杂志，2023，31（2）：84-88.

YANG C Q，WANG X M，WANG L，et al. Research pro-gress on mechanism of mesenchymal stem cells promoting tendon healing[J]. Chin J Tradit Med Traumatol Orthop，2023，31（2）：84-88.

方雨婷，柳直，张双明，等. 基于“肝肾同源”理论辨治前交叉韧带自体肌腱重建术后腱骨愈合探析[J]. 中国民族民间医药，2022，8（17）：18-21.

FANG Y T，LIU Z，ZHANG S M，et al. Differentiation and treatment of tendon bone healing after the anterior cruciate ligament autologous tendon reconstruction based on the theory of “homology of liver and kidney”[J]. Chin J Ethnomed Ethnopharmacy，2022，8（17）：18-21.

ZHU M，LIN T M，LIM K S，et al. Novel growth factor combination for improving rotator cuff repair：a rat in vivo study[J]. Am J Sports Med，2022，50（4）：1044-1053.

GARDNER B B，HE T C，WU S，et al. Growth factor expression during healing in 3 distinct tendons[J]. J Hand Surg Glob Online，2022，4（4）：214-219.

KOCH D W，SCHNABEL L V，ELLIS I M，et al. TGF-β2 enhances expression of equine bone marrow-derived mesen-chymal stem cell paracrine factors with known associations to tendon healing[J]. Stem Cell Res Ther，2022，13（1）：477.

NIU X B，SUBRAMANIAN A，HWANG T H，et al. Tendon cell regeneration is mediated by attachment site-resident progenitors and BMP signaling[J]. Curr Biol，2020，30（17）：3277-3292.e5.

HAN L，LIU H，FU H J，et al. Exosome-delivered BMP-2 and polyaspartic acid promotes tendon bone healing in rotator cuff tear via Smad/RUNX2 signaling pathway[J]. Bioengineered，2022，13（1）：1459-1475.

HAN L，HU Y G，JIN B，et al. Sustained BMP-2 release and platelet rich fibrin synergistically promote tendon-bone healing after anterior cruciate ligament reconstruction in rat[J]. Eur Rev Med Pharmacol Sci，2019，23（20）：8705-8712.

XU L，QIAN Z，WANG S N，et al. Galectin-3 enhances osteogenic differentiation of precursor cells from patients with diffuse idiopathic skeletal hyperostosis via Wnt/β-catenin signaling[J]. J Bone Miner Res，2022，37（4）：724-739.

CHEN Y，ZHANG T，WAN L Y，et al. Early treadmill running delays rotator cuff healing via neuropeptide Y media-ted inactivation of the Wnt/β-catenin signaling[J]. J Orthop Translat，2021，30：103-111.

CHEN J Y，SVENSSON J，SUNDBERG C J，et al. FGF gene expression in injured tendons as a prognostic biomarker of 1-year patient outcome after Achilles tendon repair[J]. J Exp Orthop，2021，8（1）：20.

GUO D S，LI H，LIU Y B，et al. Fibroblast growth factor-2 promotes the function of tendon-derived stem cells in Achilles tendon restoration in an Achilles tendon injury rat model[J]. Biochem Biophys Res Commun，2020，521（1）：91-97.

JIAO X，ZHANG Y X，LI W T，et al. HIF-1α inhibition attenuates severity of Achilles tendinopathy by blocking NF-κB and MAPK pathways[J]. Int Immunopharmacol，2022，106：108543.

HUANG J C，LIN J L，LI C B，et al. Palovarotene can attenuate heterotopic ossification induced by tendon stem cells by downregulating the synergistic effects of Smad and NF-κB signaling pathway following stimulation of the inflammatory microenvironment[J]. Stem Cells Int，2022，2022：1560943.

ZHANG X T，JIANG H J，LIANG Z R，et al. Osteopractic total flavone promoting rat extra-articular tendon-bone healing through mTOR pathway[J]. China J Orthop Traumatol，2018，31（3）：248-253.

LI X Z，SU Z，SHEN K Y，et al. Eugenol-preconditioned mesenchymal stem cell-derived extracellular vesicles promote antioxidant capacity of tendon stem cells in vitro and in vivo[J]. Oxid Med Cell Longev，2022，2022：3945195.

BUHRMANN C，MOBASHERI A，BUSCH F，et al. Curcumin modulates nuclear factor kappa B （NF-kappa B）-mediated inflammation in human tenocytes in vitro：role of the phosphatidylinositol 3-kinase/Akt pathway[J]. J Biol Chem，2011，286（32）：28556-28566.

谢求恩，何江，谢心军，等. 续筋接骨液与自体富血小板血浆促进兔肩袖腱骨界面愈合的实验研究[J]. 中国中医骨伤科杂志，2020，28（8）：1-7.

XIE Q E，HE J，XIE X J，et al. Experimental study on the auxo-action of Xujin jiegu liquid and APRP on tendon bone healing of rabbit rotator cuff[J]. Chin J Tradit Med Traumatol Orthop，2020，28（8）：1-7.

李洲，韩沛林，陆文君，等. 调控TGF-β1促进损伤肌腱优质愈合的研究进展[J]. 哈尔滨医科大学学报，2019，53（1）：106-109.

LI Z，HAN P L，LU W J，et al. Research progress on regulating TGF-β1 to promote high-quality healing of injured tendon[J]. J Harbin Med Univ，2019，53（1）：106-109.

乔明珠，吕浩，胡芷苜，等. 基于Wnt/β-catenin信号通路的复方补肾活血颗粒对骨髓间充质干细胞成骨、成脂分化的影响[J]. 中国中医药信息杂志，2023，9（11）：107-113.

QIAO M Z，LYU H，HU Z M，et al. Effects of Compound bushen huoxue granules on osteogenic and lipogenic differentiation of bone marrow mesenchymal stem cells based on Wnt/β-catenin signaling pathway[J]. Chin J Inf Tradit Chin Med，2023，9（11）：107-113.

TIAN X G，JIANG H J，CHEN Y H，et al. Baicalein acce-lerates tendon-bone healing via activation of Wnt/β-catenin signaling pathway in rats[J]. Biomed Res Int，2018，2018：3849760.

ZHANG X Y，CHEN Y P，ZHANG C，et al. Icariin acce-lerates fracture healing via activation of the Wnt1/β-catenin osteogenic signaling pathway[J]. Curr Pharm Biotechnol，2020，21（15）：1645-1653.

ZHANG X Y，CHEN Y P，ZHANG C，et al. Effects of icariin on the fracture healing in young and old rats and its mechanism[J]. Pharm Biol，2021，59（1）：1245-1255.

许华亮，宋炎成，张俊辉，等. 小白菊内酯通过NF-κB信号通路促进炎症环境中肌腱干细胞的成骨分化[J]. 黑龙江中医药，2021，50（3）：76-78.

XU H L，SONG Y C，ZHANG J H，et al. Parthenolide promotes osteogenic differentiation of tendon stem cells in inflammatory environment through NF-κB signaling pathway[J]. Heilongjiang J Tradit Chin Med，2021，50（3）：76-78.

史友刚. 不同浓度三七总皂苷对大鼠肌腱干细胞成骨分化及Osx、Runx2、β-catenin表达影响的实验研究[D]. 成都：成都体育学院，2022.

Shi Y G. Effect of total saponins of Panax notoginseng at different concentrations on osteogenic differentiation and expression of Osx，Runx2 and β-catenin in rat tendon stem cells [D]. Chengdu：Chengdu Sport University，2022.

刘晓华，孙晋，马佳，等. 三七总皂苷对腱骨愈合的促进作用[J]. 科技导报，2020，38（6）：41-45.

LIU X H，SUN J，MA J，et al. The promoting effect of total saponins of Panax notoginseng for tendon and bone healing[J]. Sci Technol Rev，2020，38（6）：41-45.

ZHOU H Y，JIANG S，LI P F，et al. Improved tendon healing by a combination of tanshinone ⅡA and miR-29b inhibitor treatment through preventing tendon adhesion and enhancing tendon strength[J]. Int J Med Sci，2020，17（8）：1083-1094.

WANG C L，SHA Y Q，WANG S X，et al. Lysyl oxidase suppresses the inflammatory response in anterior cruciate ligament fibroblasts and promotes tissue regeneration by targeting myotrophin via the nuclear factor-kappa B pathway[J]. J Tissue Eng Regen Med，2020，14（8）：1063-1076.

BAI J W，XU J X，HANG K，et al. Glycyrrhizic acid promotes osteogenic differentiation of human bone marrow stromal cells by activating the Wnt/β-catenin signaling pathway[J]. Front Pharmacol，2021，12：607635.

徐众华，许炯博，钱文武，等. 桃红四物汤对兔肩袖损伤的修复作用及机制[J]. 中国药房，2021，32（24）：2975-2979.

XU Z H，XU J B，QIAN W W，et al. Repair effect and mechanism of Taohong siwu decoction on rotator cuff injury in rabbits[J]. China Pharm，2021，32（24）：2975-2979.

陈能，吕燃，谭方，等. 六味地黄丸组方对前交叉韧带损伤患者TGF-β1、BMP-2基因表达及术后功能康复的影响[J]. 现代生物医学进展，2022，22（6）：1174-1179.

CHEN N，LYU R，TAN F，et al. Effects of Liuwei dihuang pills prescription on TGF-β1，BMP-2 gene expression and postoperative functional rehabilitation in patients with anterior cruciate ligament injury[J]. Prog Mod Biomed，2022，22（6）：1174-1179.

李凯明，李玲慧，朱立国，等. 补肾活血中药对成骨细胞增殖、分化作用的研究进展[J]. 陕西中医，2019，40（7）：979-981.

LI K M，LI L H，ZHU L G，et al. Research progress on the proliferation and differentiation of osteoblasts by Chinese herbs for tonifying kidney and promoting blood circulation[J]. Shaanxi J Tradit Chin Med，2019，40（7）：979-981.

朱余俊，吕浩，江渟. 复方补肾活血颗粒对人骨髓间充质干细胞增殖及Wnt/PI3K-Akt信号通路相关蛋白表达的影响[J]. 中国中医药信息杂志，2022，29（3）：79-84.

ZHU Y J，LYU H，JIANG T. Effects of Compound bushen huoxue granules on proliferation of bone marrow mesenchymal stem cells and expression of related proteins in Wnt/PI3K-Akt signaling pathway[J]. Chin J Inf Tradit Chin Med，2022，29（3）：79-84.

杨杰. 复方接骨片对异体肌腱重建兔前交叉韧带腱-骨界面影响的实验研究[D]. 沈阳：辽宁中医药大学，2020.

YANG J. Experimental study on the effect of Compound bone-setting tablet on tendon-bone interface reconstruction of rabbit anterior cruciate ligament with allogenic tendon[D].Shenyang：Liaoning University of Traditional Chinese Medicine，2020.

乔宇. 基于网络药理学探讨复方接骨片促进ACL断裂重建后腱骨愈合的机制[D]. 沈阳：辽宁中医药大学，2021.

QIAO Y. Based on network pharmacology on the mechanism of Compound jiegu tablet in promoting tendon hea-ling after ACL rupture and reconstruction[D].Shenyang：Liaoning University of Traditional Chinese Medicine，2021.

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