Meta-analysis of the effects of <italic style="font-style: italic">ABCB1</italic> genotype on the efficacy and safety of taxanes in the treatment of breast cancer

ZHANG Shufang; LI Yan; LIU Lun; GENG Xiaoning; ZHOU Bo; ZHANG Zhongtao; LIU Fulei

doi:10.6039/j.issn.1001-0408.2024.10.18

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Meta-analysis of the effects of ABCB1 genotype on the efficacy and safety of taxanes in the treatment of breast cancer

更新时间：2025-09-25

- Meta-analysis of the effects of ABCB1 genotype on the efficacy and safety of taxanes in the treatment of breast cancer
- ZHONGGUO YAOFANG Vol. 35, Issue 10, Pages: 1254-1259(2024)
- 作者机构：
  
  1.青岛大学附属泰安市中心医院药学部，山东泰安　271099
  2.山东第一医科大学第一附属医院（山东省千佛山医院）临床药学科，济南　250014
  3.青岛大学附属泰安市中心医院博士后工作站，山东泰安　271099
  4.青岛大学附属泰安市中心医院肿瘤精确干预与转化医学实验室，山东泰安　271099
  5.青岛大学附属泰安市中心医院科研科，山东泰安　271099
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.10.18
  CLC： R969
- Received：03 November 2023，
  
  Revised：2024-04-24，
  
  Accepted：28 April 2024，
  
  Published：30 May 2024
- 稿件说明：
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张恕芳,李妍,刘伦,等.ABCB1基因型对紫杉烷类药物用于乳腺癌疗效和安全性影响的Meta分析[J].中国药房,2024,35(10):1254-1259.

ZHANG Shufang,LI Yan,LIU Lun,et al.Meta-analysis of the effects of ABCB1 genotype on the efficacy and safety of taxanes in the treatment of breast cancer[J].ZHONGGUO YAOFANG,2024,35(10):1254-1259.
张恕芳,李妍,刘伦,等.ABCB1基因型对紫杉烷类药物用于乳腺癌疗效和安全性影响的Meta分析[J].中国药房,2024,35(10):1254-1259. DOI： 10.6039/j.issn.1001-0408.2024.10.18.

ZHANG Shufang,LI Yan,LIU Lun,et al.Meta-analysis of the effects of ABCB1 genotype on the efficacy and safety of taxanes in the treatment of breast cancer[J].ZHONGGUO YAOFANG,2024,35(10):1254-1259. DOI： 10.6039/j.issn.1001-0408.2024.10.18.

摘要

目的

评价

ABCB1

基因型对紫杉烷类药物用于乳腺癌疗效和安全性的影响。

方法

检索Embase、Cochrane图书馆、PubMed、中国知网和万方数据，收集紫杉烷类药物用于乳腺癌的队列研究和病例-对照研究。检索时限为建库起至2023年7月。筛选文献、提取数据和评价质量后，采用RevMan 5.3软件进行Meta分析。

结果

共纳入11项研究，共计1 321例患者。3种基因型与有效率及发生骨髓抑制、神经毒性（除

ABCB1

C1236T等位基因和隐性基因外）、超敏反应均无关（

＞0.05）。亚组分析结果显示，使用蒽环类药物+5-氟尿嘧啶+环磷酰胺+紫杉烷类药物时，

ABCB1

C1236T显性模型与有效率有关（

＜0.05）；使用紫杉烷类药物+曲妥珠单抗时，

ABCB1

C3435T隐性模型与有效率有关（

＜0.05）。样本量≥100、使用环磷酰胺+表柔比星+5-氟尿嘧啶+紫杉醇或环磷酰胺+表柔比星+紫杉醇+曲妥珠单抗或环磷酰胺+表柔比星+5-氟尿嘧

啶+曲妥珠单抗+紫杉醇方案的

ABCB1

C1236T等位基因模型和隐性模型以及非洲地区、样本量＜100的隐性模型与发生周围神经病变，隐性模型与发生皮肤不良反应均有关（

＜0.05）。样本量≥100时发生中性粒细胞计数减少与

ABCB1

C3435T隐性模型，样本量＜100、使用多西他赛+表柔比星+环磷酰胺时发生白细胞计数减少与等位基因模型和显性模型，发生感染与显性模型均有关（

＜0.05）。样本量＜100时发生中性粒细胞计数减少与

ABCB1

G2677T/A等位基因模型，样本量≥100时发生水肿与等位基因模型和隐性模型，发生感染与等位基因模型和显性模型均有关，尤其在中性粒细胞计数伴发热患者中（

＜0.05）。

结论

ABCB1

基因型与紫杉烷类药物用于乳腺癌患者的有效率无相关性，但

ABCB1

C3435T与发生中性粒细胞计数减少、白细胞计数减少和感染有关，

ABCB1

C1236T与发生神经毒性和皮肤不良反应有关，

ABCB1

G2677T/A与发生中性粒细胞计数减少、感染和水肿有关。

Abstract

OBJECTIVE

To evaluate the effects of

ABCB1

genotypes on the efficacy and safety of taxanes in the treatment of breast cancer.

METHODS

By searching Embase， the Cochrane Library， PubMed， CNKI， and Wanfang databases， cohort studies and case-control studies about taxanes in the treatment of breast cancer were collected from the establishment of the database to July 2023. After screening literature， extracting data and evaluating quality， meta-analysis was performed by using RevMan 5.3 software.

RESULTS

A total of 11 studies were included， involving 1 321 patients. There was no correlation between the three genotypes and effective rate， the incidence of myelosuppression， the incidence of neurotoxicity （except for the allele and recessive model of

ABCB1

C1236T）， and the incidence of hypersensitivity reactions （

＞0.05）. The subgroup analysis showed that there was a correlation between

ABCB1

C1236T dominant model and effective rate when using anthracyclines+5-fluorouracil+cyclophosphamide+taxanes （

＜0.05）， there was a correlation between

ABCB1

C3435T recessive model and effective rate when using taxanes+trastuzumab （

＜0.05）.

ABCB1

C1236T allele model and recessive model were correlated with sample size ≥100 and using cyclophosphamide+epirubicin+5-fluorouracil+paclitaxel or cyclophosphamide+epirubicin+paclitaxel+trastuzumab or cyclophosphamide+epirubicin+5-fluorouracil+trastuzumab+paclitaxel regimens； recessive model with sample size ＜100 and the African region were correlated with the incidence of peripheral neuropathy； recessive model was correlated with cutaneous adverse reactions （

＜0.05）.

ABCB1

C3435T recessive model was correlated with the incidence of reduced neutrophil count with sample size ≥100； the incidence of white blood cell count reduction with sample size ＜100 and using docetaxel+epirubicin+cyclophosphamide was correlated with both the allele model and the dominant model； the incidence of infections was correlated with the dominant model （

＜0.05）. The incidence of neutrophil count reduction with the sample size ＜100 was correlated with allele model of

ABCB1

G2677T/A； the incidence of edema with sample size ≥100 was correlated with allele model and recessive model； the incidence of infection was correlated with allele model and dominant model， especially in patients with neutrophil count complicated with fever （

＜0.05）.

CONCLUSIONS

ABCB1

genotypes are not correlated with effective rate of taxanes in the treatment of breast cancer， but

ABCB1

C3435T genotype is associated with decreased neutrophil counts， decreased white blood cell counts and infections；

ABCB1

C1236T genotype is associated with neurotoxicity and cutaneous adverse reactions；

ABCB1

G2677T/A genotype is associated with decreased neutrophil counts， infections， and edema.

关键词

Keywords

references

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Meta-analysis of the effects of ABCB1 genotype on the efficacy and safety of taxanes in the treatment of breast cancer

DOI：10.6039/j.issn.1001-0408.2024.10.18

摘要

Abstract

关键词

Keywords

references