Research on the role of resveratrol against breast cancer

GAO Qingdong; DUAN Xufang; LI Yan; XU Tao; YU Yangyang; BAI Guodong

doi:10.6039/j.issn.1001-0408.2024.11.22

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Research on the role of resveratrol against breast cancer

更新时间：2024-06-11

- Research on the role of resveratrol against breast cancer
- ZHONGGUO YAOFANG Vol. 35, Issue 11, Pages: 1408-1412(2024)
- 作者机构：
  
  1.佳木斯市中医医院药剂科，黑龙江佳木斯　154002
  2.佳木斯市向阳区人民医院药剂科，黑龙江佳木斯　154002
  3.黑龙江中医药大学附属第四医院药剂科，哈尔滨　150006
  4.佳木斯市中医医院制剂室，黑龙江佳木斯　154002
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.11.22
  CLC： R965
- Published：15 June 2024，
  
  Received：23 January 2024，
  
  Revised：22 May 2024，
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高庆东,段旭昉,李妍等.白藜芦醇抗乳腺癌的研究进展 ^Δ[J].中国药房,2024,35(11):1408-1412.

GAO Qingdong,DUAN Xufang,LI Yan,et al.Research on the role of resveratrol against breast cancer[J].ZHONGGUO YAOFANG,2024,35(11):1408-1412.
高庆东,段旭昉,李妍等.白藜芦醇抗乳腺癌的研究进展 ^Δ[J].中国药房,2024,35(11):1408-1412. DOI： 10.6039/j.issn.1001-0408.2024.11.22.

GAO Qingdong,DUAN Xufang,LI Yan,et al.Research on the role of resveratrol against breast cancer[J].ZHONGGUO YAOFANG,2024,35(11):1408-1412. DOI： 10.6039/j.issn.1001-0408.2024.11.22.

摘要

乳腺癌的发病率在女性恶性肿瘤中高居榜首，具有侵袭性强、恶性程度高、预后差的特征。白藜芦醇是一种植物抗氧化剂，在对抗乳腺癌发生和发展中具有潜在的多效性。本文通过评估多个体外和体内研究以探索白藜芦醇干预乳腺癌的作用机制，发现白藜芦醇可通过诱导细胞凋亡，调控自噬，抑制糖酵解，调节肿瘤微环境、基质金属蛋白酶、上皮-间质转化、耐药蛋白等的表达，来削弱乳腺癌细胞的增殖和存活能力，抑制乳腺癌细胞的生长、转移和侵袭，逆转乳腺癌细胞对阿霉素的耐药。白藜芦醇的临床试验研究数量有限，主要是关于其对乳腺癌的预防作用，这可能是影响全面评估白藜芦醇抗癌效果的原因之一。

Abstract

Breast cancer （BC） ranks first in the incidence rate of female malignant tumor， the notable features of which include high invasive behavior， high malignant degree and poor prognosis. Resveratrol， a plant antioxidant， has been identified as a potential therapeutic agent for the occurrence and progress of BC. This article explores the mechanism of resveratrol intervention in BC by evaluating several

in vitro

and

in vivo

studies. It was found that resveratrol can weaken the proliferation and survival ability of BC cells， suppress their growth， metastasis， and invasion， and reverse their resistance to adriamycin by promoting cell apoptosis， regulating autophagy， inhibiting glycolysis and regulating the tumor microenvironment， expressions of matrix metalloproteinases， epithelial-mesenchymal transition and drug-resistant proteins， etc. The limited number of clinical trial studies on resveratrol， mainly focusing on prevention effect of it on breast cancer， may be one of the reasons that affect the comprehensive evaluation of the anti-cancer efficacy of resveratrol.

关键词

白藜芦醇乳腺癌细胞凋亡自噬糖酵解肿瘤微环境细胞侵袭细胞转移耐药

Keywords

breast cancercell apoptosisautophagyglycolysistumor microenvironmentcell invasioncell metastasisdrug resistance

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