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Study progress on pharmacogenomics of sodium-glucose linked transporter 2 inhibitors
- ZHONGGUO YAOFANG Vol. 35, Issue 14, Pages: 1790-1794(2024)
- 作者机构：
1.江南大学附属医院药学部，江苏 无锡 214000
2.徐州医科大学药学院，江苏 徐州 221000
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2024.14.21
CLC： R977.1+5;R968Published：30 July 2024，
Received：20 February 2024，
Revised：25 June 2024，
- 稿件说明：
扫 描 看 全 文
庄永如,宋金方.钠-葡萄糖耦联转运体2抑制剂的药物基因组学研究进展 Δ[J].中国药房,2024,35(14):1790-1794.
ZHUANG Yongru,SONG Jinfang.Study progress on pharmacogenomics of sodium-glucose linked transporter 2 inhibitors[J].ZHONGGUO YAOFANG,2024,35(14):1790-1794.
庄永如,宋金方.钠-葡萄糖耦联转运体2抑制剂的药物基因组学研究进展 Δ[J].中国药房,2024,35(14):1790-1794. DOI： 10.6039/j.issn.1001-0408.2024.14.21.
ZHUANG Yongru,SONG Jinfang.Study progress on pharmacogenomics of sodium-glucose linked transporter 2 inhibitors[J].ZHONGGUO YAOFANG,2024,35(14):1790-1794. DOI： 10.6039/j.issn.1001-0408.2024.14.21.
摘要
钠-葡萄糖耦联转运体2抑制剂（SGLT2i）是一类新型口服降糖药物，广泛应用于2型糖尿病患者的降糖治疗，但由于患者的遗传背景差异，常导致药物治疗的反应性多样。本文通过综述SGLT2i的药物基因组学研究报道，发现
UGT1A9
、
UGT2B4
、
SLC5A2
、
ABCB1
、
PNPLA3
、
WFS1
基因变异可能影响SGLT2i的药代动力学以及SGLT2i在改善非酒精性脂肪性肝病、减重等方面的降糖外效应，但尚无足够的临床证据支持基因多态性影响SGLT2i的降糖疗效。
Abstract
odium-glucose linked transporter 2 inhibitors（SGLT2i） are novel oral hypoglycaemic agents and are widely used for hypoglycemic therapy in patients with type 2 diabetes mellitus， but differences in the genetic backgrounds of patients often lead to variable responsiveness to drug therapy. By summarizing the pharmacogenomic studies of SGLT2i， the article found that the genetic variants of
UGT1A9
，
UGT2B4
，
SLC5A2
，
ABCB1
，
PNPLA3
and
WFS1
may influence the pharmacokinetics of SGLT2i and the external hypoglycemic effects of SGLT2i in improving non-alcoholic fatty liver disease， weight loss and so on， but there is no clinical evidence that genetic polymorphisms affect the hypoglycemic efficacy of SGLT2i.
关键词
基因多态性钠-葡萄糖耦联转运体2抑制剂个体差异药物基因组学药代动力学药效动力学
Keywords
SGLT2iindividual differencespharmacogenomicspharmacokineticspharmacodynamics
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