Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway

LI Xue; ZHANG Yunlong; SONG Ziyi; ZHANG Zhujiang; YANG Chao; REN Tianjiao; JIA Linzhen

doi:10.6039/j.issn.1001-0408.2024.14.22

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Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway

更新时间：2024-07-25

- Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway
- ZHONGGUO YAOFANG Vol. 35, Issue 14, Pages: 1795-1800(2024)
- 作者机构：
  
  1.齐齐哈尔医学院基础医学院，黑龙江齐齐哈尔　161006
  2.黑龙江省药食同源资源与代谢性疾病防治重点实验室，黑龙江齐齐哈尔　161006
  3.齐齐哈尔医学院公共卫生学院，黑龙江齐齐哈尔　161006
  4.齐齐哈尔医学院口腔医学院，黑龙江齐齐哈尔　161006
  5.齐齐哈尔医学院医学技术学院，黑龙江齐齐哈尔　161006
  6.齐齐哈尔医学院药学院，黑龙江齐齐哈尔　161006
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.14.22
  CLC： R965;R285.5
- Published：30 July 2024，
  
  Received：20 January 2024，
  
  Revised：18 June 2024，
- 稿件说明：
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李雪,张云龙,宋子毅等.中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展 ^Δ[J].中国药房,2024,35(14):1795-1800.

LI Xue,ZHANG Yunlong,SONG Ziyi,et al.Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway[J].ZHONGGUO YAOFANG,2024,35(14):1795-1800.
李雪,张云龙,宋子毅等.中药通过PI3K/Akt信号通路干预肾间质纤维化的研究进展 ^Δ[J].中国药房,2024,35(14):1795-1800. DOI： 10.6039/j.issn.1001-0408.2024.14.22.

LI Xue,ZHANG Yunlong,SONG Ziyi,et al.Research progress on the intervention of traditional Chinese medicine in renal interstitial fibrosis based on PI3K/Akt signaling pathway[J].ZHONGGUO YAOFANG,2024,35(14):1795-1800. DOI： 10.6039/j.issn.1001-0408.2024.14.22.

摘要

肾间质纤维化（RIF）是慢性肾病的主要病理表现结果，由于其发生机制复杂，临床上尚无特效治疗措施。磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）信号通路的异常激活及其下游靶基因的活化是RIF发生进展的关键诱因。中药具有药效确切、毒副作用小等特点，可多靶点、多途径协同调控RIF的发生进展。本文以PI3K/Akt信号通路为核心，对中药在RIF治疗中的作用靶点及调控机制进行归纳，发现多种中药有效成分（如青藤碱、芒果苷、圆锥绣球提取物等）以及复方（如复肾功方、气邦益肾方等）可通过该通路抑制成纤维细胞增殖、改善炎症反应与氧化应激、维持线粒体稳态、减缓铁死亡发生等，从而延缓RIF的发生进展。

Abstract

Renal

interstitial fibrosis（RIF） is the main pathological manifestation of chronic kidney disease. Due to the complexity of the mechanism， there is no specific treatment for RIF in clinical practice. The abnormal activation of the phosphatidylinositol 3-kinase （PI3K）/protein kinase B（Akt） signaling pathway and the activation of downstream target genes are key drivers of RIF induction and progression. Traditional Chinese medicine has the characteristics of precise efficacy and minimal toxic side effects， and the occurrence and development of RIF can be regulated by multiple targets and mutual coordination. This review focuses on the PI3K/Akt signaling pathway and summarizes the potential targets and regulatory mechanisms of traditional Chinese medicine in the treatment of RIF. It is found that various effective ingredients （such as sinomenine， mangiferin， coumarin derivates from

Hydrangea paniculata

， etc.） and formulas （such as Fushengong decoction， Qi-Bang-Yi-Shen formula， etc.） of traditional Chinese medicine can inhibit fibroblast proliferation， improve inflammation and oxidative stress， maintain mitochondrial stability， and slow down ferroptosis through this pathway， thereby delaying the occurrence and progression of RIF.

关键词

中药PI3K/Akt信号通路肾间质纤维化作用机制

Keywords

PI3K/Akt signaling pathwayrenal interstitial fibrosisaction of mechanism

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