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Research progress of active components and compounds of traditional Chinese medicine improving liver fibrosis by regulating JAK/STAT signaling pathway
- ZHONGGUO YAOFANG Vol. 35, Issue 15, Pages: 1923-1927(2024)
- 作者机构：
1.广西中医药大学研究生学院，南宁 530001
2.广西中医药大学第一附属医院脾胃病科，南宁 530001
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2024.15.21
CLC： R965;R285.5Published：15 August 2024，
Received：02 December 2023，
Revised：25 March 2024，
- 稿件说明：
扫 描 看 全 文
邓斯铭,刘礼剑,黎丽群等.中药活性成分及复方调控JAK/STAT信号通路改善肝纤维化的研究进展 Δ[J].中国药房,2024,35(15):1923-1927.
DENG Siming,LIU Lijian,LI Liqun,et al.Research progress of active components and compounds of traditional Chinese medicine improving liver fibrosis by regulating JAK/STAT signaling pathway[J].ZHONGGUO YAOFANG,2024,35(15):1923-1927.
邓斯铭,刘礼剑,黎丽群等.中药活性成分及复方调控JAK/STAT信号通路改善肝纤维化的研究进展 Δ[J].中国药房,2024,35(15):1923-1927. DOI： 10.6039/j.issn.1001-0408.2024.15.21.
DENG Siming,LIU Lijian,LI Liqun,et al.Research progress of active components and compounds of traditional Chinese medicine improving liver fibrosis by regulating JAK/STAT signaling pathway[J].ZHONGGUO YAOFANG,2024,35(15):1923-1927. DOI： 10.6039/j.issn.1001-0408.2024.15.21.
摘要
肝纤维化是各种慢性肝损伤的病理过程，若不及时治疗，最终可能导致肝硬化或肝癌。Janus激酶/信号转导及转录激活蛋白（JAK/STAT）信号通路与肝纤维化的发生发展密切相关。本文基于JAK/STAT信号通路总结了中药活性成分及复方改善肝纤维化的研究进展，发现活血化瘀类（如鬼箭羽醇、紫杉醇等成分及二十五味松石丸、肝复康等复方）、清热解毒类（如桦木酸、杠板归总黄酮等成分及片仔癀、克癀胶囊等复方）、疏肝行气类（如秦皮素、葫芦素B等成分及柴胡疏肝散、小柴胡汤等复方）中药活性成分和复方均可通过抑制JAK/STAT信号通路活性，降低炎症反应，抑制肝星状细胞增殖等，发挥改善肝纤维化的作用。
Abstract
Hepatic fibrosis is a pathological process of chronic liver injury. Without timely intervention and treatment， liver fibrosis may eventually lead to liver cirrhosis and cancer. Janus kinase （JAK）/signal transducer and activator of transcription （STAT） signaling pathway is closely associated with the occurrence and development of liver fibrosis. Based on this， this paper summarized and analyzed the mechanism and effects of active ingredients and compounds of traditional Chinese medicine improving liver fibrosis based on JAK/STAT signaling pathway. It is found that the active ingredients and compounds of traditional Chinese medicine that promote blood circulation and remove blood stasis （ingredients such as ethanol extract of
Euonymus alatus
and paclitaxel， as well as compounds such as Ershiwuwei songshi pill and Ganfukang）， clear away heat and toxic material （ingredients such as betulinic acid， total flavonoids from
Persicaria perfoliata
， as well as compounds such as Pianzaihuang and Kehuang capsules）， and sooth the liver and promote qi circulation （ingredients such as fraxetin and cucurbitacin B， as well as compounds such as Chaihu shugan powder and Xiaochaihu decoction） can all relieve liver fibrosis by inhibiting the activity of the JAK/STAT signaling pathway， reducing inflam
matory reactions， and inhibiting the proliferation of hepatic stellate cells.
关键词
肝纤维化JAK/STAT信号通路中药活性成分复方
Keywords
JAK/STAT signaling pathwaytraditional Chinese medicineactive ingredientscompounds
references
SHE S P，WU X N，ZHENG D F，et al. PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target[J]. J Hepatol，2020，72（3）：506-518.
WANG S，FRIEDMAN S L. Hepatic fibrosis：a convergent response to liver injury that is reversible[J]. J Hepatol，2020，73（1）：210-211.
ASRANI S K，DEVARBHAVI H，EATON J，et al. Burden of liver diseases in the world[J]. J Hepatol，2019，70（1）：151-171.
ZHAO Z M，ZHU C W，HUANG J Q，et al. Efficacy and safety of Fuzheng huayu tablet on persistent advanced liver fibrosis following 2 years entecavir treatment：a single arm clinical objective performance criteria trial[J]. J Ethnopharmacol，2022，298：115599.
中国中西医结合学会肝病专业委员会. 肝纤维化中西医结合诊疗指南：2019年版[J]. 中国中西医结合杂志，2019，39 （11）：1286-1295.
Liver Disease Professional Committee of the Chinese Association of Traditional Chinese and Western Medicine. Guidelines for integrated traditional Chinese and Western medicine diagnosis and treatment of liver fibrosis：2019 edition[J]. Chin J Integr Tradit West Med，2019，39 （11）：1286-1295.
白彦铭，梁爽，周波. 中西医联合治疗肝纤维化的研究进展[J/OL]. 实用中医内科杂志，2022：1-4[2023-07-14]. http：//kns.cnki.net/kcms/detail/21.1187.R.20220913.1942.006.htmlhttp://kns.cnki.net/kcms/detail/21.1187.R.20220913.1942.006.html.
BAI Y M，LIANG S，ZHOU B. Research progress of combined treatment of liver fibrosis with traditional Chinese and Western medicine[J/OL]. J Pract Tradit Chin Intern Med，2022：1-4[2023-07-14].http：//kns.cnki.net/kcms/detail/21.1187.R.20220913.1942.006.htmlhttp://kns.cnki.net/kcms/detail/21.1187.R.20220913.1942.006.html.
WANG Z，YAO L C，HU X，et al. Advancements in mesenchymal stem cell therapy for liver cirrhosis：unvei- ling origins，treatment mechanisms，and current research frontiers[J]. Tissue Cell，2023，84：102198.
ZHENG Y F，JI S X，LI X，et al. Qijia Rougan formula ameliorates ECM deposition in hepatic fibrosis by regula- ting the JAK1/STAT6-microRNA-23a feedback loop in macrophage M2 polarization[J]. Biomed Pharmacother，2023，168：115794.
PANG Q Y，YOU L，MENG X M，et al. Regulation of the JAK/STAT signaling pathway：the promising targets for cardiovascular disease[J]. Biochem Pharmacol，2023，213：115587.
PHILIPS R L，WANG Y X，CHEON H，et al. The JAK-STAT pathway at 30：much learned，much more to do[J]. Cell，2022，185（21）：3857-3876.
ZHAO L，LI J，MO G，et al. Recombinant protein EBI3 attenuates Clonorchis sinensis-induced liver fibrosis by inhibiting hepatic stellate cell activation in mice[J]. Parasit Vectors，2023，16（1）：246.
CAO S Y，ZHU C，FENG J，et al. Helicobacter hepaticus infection induces chronic hepatitis and fibrosis in male BALB/c mice via the activation of NF-κB，Stat3，and MAPK signaling pathways[J]. Helicobacter，2020，25（2）：e12677.
RAMADAN H K，BADR G，RAMADAN N K，et al. Enhanced immune responses，PI3K/AKT and JAK/STAT signaling pathways following hepatitis C virus eradication by direct-acting antiviral therapy among Egyptian patients：a case control study[J]. Pathog Dis，2021，79（3）：ftab008.
SAALIM M，RESHAM S，MANZOOR S，et al. IL-22 in hepatocyte’s survival of Pakistani patients with end stage liver disease：an insight into IL-22 mediated hepato-regenerative pathway[J]. Mol Biol Rep，2019，46（1）：1127-1138.
王咏兰，陶柏楠，陈明环，等. 基于JAK2/STAT3信号通路探究鬼箭羽醇提物抗CCl4诱导C57BL/6J小鼠肝纤维化作用机制[J]. 中国药理学通报，2023，39（5）：875-881.
WANG Y L，TAO B N，CHEN M H，et al. Effects of ethanolic extracts of Euonymus alatus on CCl4-induced hepatic fibrosis in mice based on JAK2/STAT3 signaling pathway and its mechanism[J]. Chin Pharmacol Bull，2023，39（5）：875-881.
冯锦，吴建红，熊响莲，等. 紫杉醇通过调控JAK2/STAT3通路对肝纤维化模型大鼠Th17/Treg影响的研究[J]. 中国免疫学杂志，2022，38（13）：1564-1569.
FENG J，WU J H，XIONG X L，et al. Paclitaxel regulates effect of JAK2/STAT3 pathway on Th17/Treg in hepatic fibrosis model rats[J]. Chin J Immunol，2022，38（13）：1564-1569.
严栋梁，邵伟斌，葛创，等. 川芎嗪对刀豆蛋白A诱导的小鼠肝纤维化JAK2/STAT3信号通路的影响[J]. 肝脏，2018，23（3）：255-259.
YAN D L，SHAO W B，GE C，et al. Effect of ligustrazine on JAK2/STAT3 signaling pathway in mouse liver fibrosis induced by concanavalin A[J]. Chin Hepatol，2018，23（3）：255-259.
徐冲，秦小东，任丽，等. 基于JAK1/STAT3信号通路研究高车前素对肝纤维化小鼠的影响[J]. 中草药，2022，53（19）：6093-6100.
XU C，QIN X D，REN L，et al. Effect of hispidulin on hepatic fibrosis mice based on JAK1/STAT3 signaling pathway[J]. Chin Tradit Herb Drugs，2022，53（19）：6093-6100.
孙墨晗，张秋菊，赵哲，等. 基于网络药理学和细胞实验探讨阿魏酸抗肝纤维化的作用机制[J].世界科学技术-中医药现代化，2023，25 （12）：3908-3919.
SUN M H，ZHANG Q J，ZHAO Z，et al. To explore the mechanism of ferulic acid against liver fibrosis based on network pharmacology and cell experiment[J]. Mod Tradit Chin Med Mater Med World Sci Technol，2023，25 （12）：3908-3919.
ZHAO H Z，WU L，ZHANG Y，et al. Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation[J]. J Ethnopharmacol，2022，296：115459.
曹后康，高雅，黄思茂，等. 杠板归总黄酮抗大鼠肝纤维化作用的机制研究[J]. 中国药理学通报，2017，33（9）：1303-1308.
CAO H K，GAO Y，HUANG S M，et al. Research on mechanism of effect of total flavonoids extracted from Polygonum perfoliatum L.on anti-hepatic fibrosis in rats[J]. Chin Pharmacol Bull，2017，33（9）：1303-1308.
欧士钰，杜凌，韦捷，等. 荔枝核总黄酮通过JAK2/STAT3信号通路抗大鼠肝纤维化的实验研究[J]. 检验医学与临床，2022，19（23）：3216-3219.
OU S Y，DU L，WEI J，et al. Effects of total flavone from Litchi chinensis Sonn. on rats with hepatic fibrosis through JAK2/STAT3 signaling pathway[J]. Lab Med Clin，2022，19（23）：3216-3219.
吴斌，王蓉，李胜男，等. 秦皮素通过调节JAK1/STAT3信号通路抑制肝纤维化[J]. 中南药学，2019，17（3）：420-425.
WU B，WANG R，LI S N，et al. Anti-fibrotic effect of fraxetin on liver fibrosis in rats by targeting the JAK1/STAT3 signaling pathway[J]. Cent South Pharm，2019，17（3）：420-425.
SALLAM A M，ESMAT A，ABDEL-NAIM A B. Cucurbitacin B attenuates CCl4-induced hepatic fibrosis in mice through inhibition of STAT3[J]. Chem Biol Drug Des，2018，91（4）：933-941.
孟霞，王学丛，丰平，等. 瘦素对大鼠肝纤维化的信号转导调控及槲寄生碱的干预作用[J]. 中国比较医学杂志，2015，25（10）：1-6.
MENG X，WANG X C，FENG P，et al. The signal transduction pathway of rats with liver fibrosis regulated by leptin and interfering effects of mistletoe alkali[J]. Chin J Comp Med，2015，25（10）：1-6.
许湘，陆华冠，谢新，等. 二十五味松石丸调节巨噬细胞表型改善CCl4诱导的大鼠肝纤维化[J]. 中药药理与临床，2023，39（6）：17-23.
XU X，LU H G，XIE X，et al. Ershiwuwei songshi pills improve CCl4 -induced liver fibrosis in rats by regulating macrophage phenotype [J]. Pharmacol Clin Chin Mater Med，2023，39（6）：17-23.
李晋，姜妙娜，贾玉杰. 肝复康对肝纤维化大鼠肝组织JAK2和STAT3表达的影响[J]. 临床肝胆病杂志，2010，26（5）：527-530.
LI J，JIANG M N，JIA Y J. Effect of Ganfukang on JAK2 and STAT3 expression in rats with liver fibrosis[J]. J Clin Hepatol，2010，26（5）：527-530.
王卫真，孟明辉，孔丽，等. Jak/Stat信号通路在经典CCl4大鼠肝纤维化模型中的动态变化及扶正化瘀方对其影响[J]. 临床肝胆病杂志，2014，30（4）：344-348.
WANG W Z，MENG M H，KONG L，et al. Role of Jak/Stat pathway in CCl4-induced rat liver fibrosis model and molecular action mechanism of Fuzheng huayu recipe in treatment of liver fibrosis[J]. J Clin Hepatol，2014，30（4）：344-348.
林春凤，熊清，宁潇雨，等. 基于网络药理学探讨EGFR/JAK1/STAT3通路在片仔癀抗肝纤维化中的作用[J]. 福建中医药，2023，9（6）：45-51.
LIN C F，XIONG Q，NING X Y，et al. To explore the role of EGFR/JAK1/STAT3 signaling pathway in anti-hepatic fibrosis based on network pharmacology[J]. Fujian J Tradit Chin Med，2023，9（6）：45-51.
倪沁雨，林佳成，涂天智，等. 基于网络药理学探讨克癀胶囊抗肝纤维化的作用机制[J]. 中西医结合肝病杂志，2023，33（6）：518-524.
NI Q Y，LIN J C，TU T Z，et al. The mechanism of Kehuang capsule against hepatic fibrosis based on network pharmacology[J]. Chin J Integr Tradit West Med Liver Dis，2023，33（6）：518-524.
娄莹莹，李佃贵，周文平，等. 肝复健方对瘦素调控肝纤维化大鼠JAK2/STAT3信号通路的影响[J]. 中医杂志，2013，54（9）：781-784.
LOU Y Y，LI D G，ZHOU W P，et al. Effect of Ganfujian formula on the JAK2/STAT3 signaling pathway in leptin-induced liver fibrosis in rats[J]. J Tradit Chin Med，2013，54（9）：781-784.
贺松其，文彬，吕志平，等. 保肝宁对肝纤维化模型大鼠肝组织形态学及JAK2、STAT3蛋白磷酸化水平的影响[J]. 上海中医药杂志，2008，42（5）：75-79.
HE S Q，WEN B，LYU Z P，et al. Influence of “Bao Gan Ning” on liver histomorphology and protein phosphorylation levels of JAK2 and STAT3 of liver fibrosis rats[J]. Shanghai J Tradit Chin Med，2008，42（5）：75-79.
杨武斌，唐金凤，米本中. 柴胡疏肝散对早期肝纤维化大鼠JAK2/STAT3信号通路的影响[J]. 癌变·畸变·突变，2022，34（3）：200-205.
YANG W B，TANG J F，MI B Z. Effects of Chaihushugan powder on the JAK2/STAT3 signaling pathway in rats with hepatic fibrosis[J]. Carcinog Teratog Mutagen，2022，34（3）：200-205.
李晋，徐尚福，金凤，等. 小柴胡汤下调JAK2，STAT3的表达治疗大鼠肝纤维化[J]. 中国实验方剂学杂志，2014，20（18）：118-122.
LI J，XU S F，JIN F，et al. Xiaochaihu tang depress expression of JAK2 and STAT3 of liver fibrosis in rats[J]. Chin J Exp Tradit Med Formulae，2014，20（18）：118-122.
张学政，吴冬冰，张学娟，等. 黄芪建中汤对肝纤维化大鼠JAK/STAT信号通路的调节作用研究[J]. 中西医结合肝病杂志，2023，33（9）：800-804，809.
ZHANG X Z，WU D B，ZHANG X J，et al. Regulatory effect of Huangqi jianzhong decoction on JAK/STAT signal pathway in rats with hepatic fibrosis[J]. Chin J Integr Tradit West Med Liver Dis，2023，33（9）：800-804，809.
厉姣龙，周振华. 柔肝方对肝纤维化小鼠肝脏内IL-22分泌和IL-22R1表达作用的研究[J]. 上海中医药大学学报，2022，36（5）：69-76.
LI J L，ZHOU Z H. Study on effects of Rougan formula on IL-22 secretion and IL-22R1 expression in liver of mice with liver fibrosis[J]. Acad J Shanghai Univ Tradit Chin Med，2022，36（5）：69-76.
郑旭锐，李长秦，项颖环，等. 加味四逆散及拆方对肝星状细胞JAK2-STAT3信号通路的影响[J]. 辽宁中医药大学学报，2012，14（3）：67-69.
ZHENG X R，LI C Q，XIANG Y H，et al. Experiments study of Jiawei sinisan and the separate components on hepatic stellate cell of JAK2-STAT3 signal pathway[J]. J Liaoning Univ Tradit Chin Med，2012，14（3）：67-69.
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