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Research progress on the prevention and treatment of cardiovascular diseases using traditional Chinese medicine for promoting blood circulation and removing blood stasis by regulating autophagy
- ZHONGGUO YAOFANG Vol. 35, Issue 16, Pages: 2048-2054(2024)
- 作者机构：
1.黑龙江中医药大学药学院，哈尔滨 150040
2.黑龙江中医药大学基础医学院，哈尔滨 150040
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2024.16.20
CLC： R285Published：30 August 2024，
Received：29 March 2024，
Revised：12 July 2024，
- 稿件说明：
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孙鑫,梁霄,李娅兰等.活血化瘀类中药通过调控细胞自噬防治心血管疾病的研究进展 Δ[J].中国药房,2024,35(16):2048-2054.
SUN Xin,LIANG Xiao,LI Yalan,et al.Research progress on the prevention and treatment of cardiovascular diseases using traditional Chinese medicine for promoting blood circulation and removing blood stasis by regulating autophagy[J].ZHONGGUO YAOFANG,2024,35(16):2048-2054.
孙鑫,梁霄,李娅兰等.活血化瘀类中药通过调控细胞自噬防治心血管疾病的研究进展 Δ[J].中国药房,2024,35(16):2048-2054. DOI： 10.6039/j.issn.1001-0408.2024.16.20.
SUN Xin,LIANG Xiao,LI Yalan,et al.Research progress on the prevention and treatment of cardiovascular diseases using traditional Chinese medicine for promoting blood circulation and removing blood stasis by regulating autophagy[J].ZHONGGUO YAOFANG,2024,35(16):2048-2054. DOI： 10.6039/j.issn.1001-0408.2024.16.20.
摘要
细胞自噬是由多分子多通路共同介导完成的，在心血管疾病中，自噬可以通过磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白（mTOR）、腺苷一磷酸活化的蛋白激酶/mTOR、丝裂原活化蛋白激酶、p53、Wnt/
β
-连环蛋白等关键信号通路发挥作用。活血化瘀类中药单体如羟基红花黄色素A、人参皂苷Rb
1
、红景天苷、川芎内酯、姜黄素等，中药复方及制剂如黄芪保心汤、桃红四物汤、通心络胶囊、双参宁心胶囊、速效救心丸等均能通过上述关键信号通路调控细胞自噬，进而缓解心血管疾病的进程。
Abstract
Autophagy is mediated by multiple molecules and pathways. In cardiovascular diseases， autophagy can play a role through key signaling pathways such as phosphoinositide 3-kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR）， adenosine monophosphate-activated protein kinase （AMPK）/mTOR， mitogen-activated protein kinases （MAPK）， p53， Wnt/
β
-catenin， etc. Traditional Chinese medicine （TCM） monomers for promoting blood circulation and removing blood stasis such as hydroxysafflor yellow A， ginsenoside Rb
1
， salidroside， ligustrin， curcumin， etc.， and TCM prescription and preparations such as Huangqi baoxin decoction， Taohong siwu decoction， Tongxinluo capsule， Shuangshen ningxin capsule， Suxiao jiuxin pills， etc. can regulate autophagy through the above-mentioned key signaling pathways， thereby alleviating the progression of cardiovascular diseases.
关键词
细胞自噬中药活血化瘀心血管疾病
Keywords
traditional Chinese medicinepromoting blood circulation and removing blood stasiscardiovascular disease
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