Investigation and analysis of the use of acetaminophen in primary medical institutions of Shaanxi province

YANG Fang; LIU Xingchen; LIU Xingyu; LIU Xiaoyong; XIANG Cheng; YANG Caijun

doi:10.6039/j.issn.1001-0408.2024.17.17

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Investigation and analysis of the use of acetaminophen in primary medical institutions of Shaanxi province

更新时间：2024-09-09

- Investigation and analysis of the use of acetaminophen in primary medical institutions of Shaanxi province
- ZHONGGUO YAOFANG Vol. 35, Issue 17, Pages: 2152-2157(2024)
- 作者机构：
  
  1.西安交通大学药学院临床药学系，西安　710115
  2.西安市高陵区医院药剂科，西安　710200
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.17.17
  CLC： R95;R971
- Published：15 September 2024，
  
  Received：17 May 2024，
  
  Revised：06 August 2024，
- 稿件说明：
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杨芳,刘星宸,刘星雨等.陕西省基层医疗机构氨酚待因使用情况调查分析[J].中国药房,2024,35(17):2152-2157.

YANG Fang,LIU Xingchen,LIU Xingyu,et al.Investigation and analysis of the use of acetaminophen in primary medical institutions of Shaanxi province[J].ZHONGGUO YAOFANG,2024,35(17):2152-2157.
杨芳,刘星宸,刘星雨等.陕西省基层医疗机构氨酚待因使用情况调查分析[J].中国药房,2024,35(17):2152-2157. DOI： 10.6039/j.issn.1001-0408.2024.17.17.

YANG Fang,LIU Xingchen,LIU Xingyu,et al.Investigation and analysis of the use of acetaminophen in primary medical institutions of Shaanxi province[J].ZHONGGUO YAOFANG,2024,35(17):2152-2157. DOI： 10.6039/j.issn.1001-0408.2024.17.17.

摘要

目的

调查分析陕西省基层医疗机构氨酚待因使用情况，为促进氨酚待因的规范、合理使用提供证据支持。

方法

按照整群分层随机抽样的方法，在陕西省全部10个省辖市中随机各选取1个区、1个县（或2个区）的基层医疗机构2020－2023年开具的所有氨酚待因处方，采用国际疾病分类（ICD）编码对现有临床诊断进行归类，对搜集的处方用药信息进行描述性分析，并采用SPSS 25.0软件对数据进行单因素分析和Logistic回归分析，找出影响用药疗程＞10 d的关键因素。

结果

本研究共收集到氨酚待因有效处方7 375张。使用氨酚待因的主要以女性（52.11%）、年龄19～64岁（66.73%）的患者为主。基于ICD编码，氨酚待因的使用涉及最多的疾病类别为肌肉骨骼系统或结缔组织疾病或症状、体征（43.48%）；排名前3位的临床诊断为关节病（25.59%）、骨折（9.95%）、牙痛（8.58%）。药品用法用量明确的7 175张处方中符合氨酚待因说明书推荐的处方有3 366张，有5.63%的处方对乙酰氨基酚日使用量超2.0 g/d的极量限制。处方用药疗程超常规限制（7 d）的处方有4 051张，超使用疗程限制（10 d）的处方有1 336张。影响用药疗程＞10 d的因素主要为医疗机构所属区域、类型以及患者性别、年龄，基层医疗机构中的陕南地区、乡镇卫生院以及老年人、女性患者用药疗程＞10 d的现象偏多。

结论

陕西省基层医疗机构氨酚待因的临床应用存在一定的不合理，主要表现在药品用法用量、临床诊断以及用药疗程不适宜；医疗机构所属区域、类型以及患者年龄、性别均会影响该类药品的用药疗程。

Abstract

OBJECTIVE

To investigate and analyze the use of acetaminophen in primary medical institutions of Shaanxi province， and to provide evidence for promoting the standardized and rational use of acetaminophen.

METHODS

According to the method of cluster stratified random sampling， all prescriptions of acetaminophen issued by primary medical institutions in one district and one county （or two districts） were randomly selected from 10 provincial cities of Shaanxi province from 2020 to 2023； the existing clinical diagnoses were classified by using the International Classification of Diseases （ICD） code， and the drug information of collected prescriptions was analyzed descriptively. SPSS 25.0 software was used for single-factor analysis and Logistic regression analysis to find out the key factors affecting the duration of medication ＞10 d.

RESULTS

A total of 7 375 valid prescriptions for acetaminophen were collected in this study. The patients who used acetaminophen were mainly female （52.11%） and aged 19-64 （66.73%）. Based on the ICD code， the disease categories most involved in the use of acetaminophen were musculoskeletal system， connective tissue diseases or symptoms and signs （43.48%）； the top 3 clinical diagnoses were joint disease （25.59%）， fracture （9.95%）， and toothache （8.58%）. Among the 7 175 prescriptions with clear drug usage and dosage， 3 366 were in line with the recommendation of acetaminophen instruction， and 5.63% of the prescriptions exceeded the maximum dose limit of acetaminophen 2.0 g/d. There were 4 051 prescriptions exceeding the conventional limit of treatment duration （7 d）， and 1 336 prescriptions exceeding the limit of treatment duration （10 d）. The main factors affecting the duration of drug treatment ＞10 d were the region and type of medical institutions， the gender and age of patients， and the phenomenon of the duration of drug treatment ＞10 d was common in the primary medical institutions from southern Shaanxi， township health centers， the elderly and female patients.

CONCLUSIONS

There are some unreasonable clinical applications of acetaminophen in primary medical institutions of Shaanxi province， which are mainly manifested in inappropriate usage and dosage， unsuitable clinical diagnosis and drug duration. The region， type of medical institution， age and gender of patients will affect the duration of this drug prescription.

关键词

氨酚待因基层医疗机构镇痛药合理用药陕西省

Keywords

primary medical institutionsanalgesicsrational drug useShaanxi province

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