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Research advances on the pathogenesis and treatment of unexplained recurrent spontaneous abortion
- ZHONGGUO YAOFANG Vol. 35, Issue 17, Pages: 2188-2192(2024)
- 作者机构：
1.宁波市第六医院药学部，浙江 宁波 315040
2.贵阳市第四人民医院药剂科，贵阳 550007
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2024.17.23
CLC： R969;R714.21Published：15 September 2024，
Received：10 March 2024，
Revised：21 July 2024，
- 稿件说明：
移动端阅览
陆冬媛,金建峰,罗伟伟等.不明原因复发性流产发病机制及治疗方法的研究进展 Δ[J].中国药房,2024,35(17):2188-2192.
LU Dongyuan,JIN Jianfeng,LUO Weiwei,et al.Research advances on the pathogenesis and treatment of unexplained recurrent spontaneous abortion[J].ZHONGGUO YAOFANG,2024,35(17):2188-2192.
陆冬媛,金建峰,罗伟伟等.不明原因复发性流产发病机制及治疗方法的研究进展 Δ[J].中国药房,2024,35(17):2188-2192. DOI： 10.6039/j.issn.1001-0408.2024.17.23.
LU Dongyuan,JIN Jianfeng,LUO Weiwei,et al.Research advances on the pathogenesis and treatment of unexplained recurrent spontaneous abortion[J].ZHONGGUO YAOFANG,2024,35(17):2188-2192. DOI： 10.6039/j.issn.1001-0408.2024.17.23.
摘要
自然流产是妊娠最常见的并发症之一，连续发生2次及以上的自然流产被定义为复发性流产（RSA），其中约有50%的患者病因不明。不明原因RSA（URSA）的发病机制尚未阐明，目前也缺乏特效治疗手段，是妇产科学研究的重点难点之一。本文对近年来URSA相关研究进行了文献调研，发现URSA发病机制与母胎界面免疫耐受失衡、滋养层细胞凋亡以及血管生成被抑制、免疫反应被激活有关。临床常采用免疫疗法（包括细胞疗法、细胞因子疗法、免疫抑制剂干预）、激素类药物、抗凝方案、中医疗法干预URSA，但部分疗法的安全性和有效性仍存在争议。
Abstract
pontaneous abortion is one of the most common complications of pregnancy， and two or more spontaneous abortions in a row are defined as recurrent spontaneous abortion （RSA）， of which about half of patients have unknown etiology. However， the pathogenesis of unexplained RSA （URSA） has not been elucidated， and the lack of effective treatment has made it one of the key and difficult points in the field of obstetrics and gynecology. This article conducts a literature review of recent research on URSA and finds that the pathogenesis of URSA is related to the imbalance of immune tolerance at the maternal-fetal interface， apoptosis of trophoblast cells， inhibition of angiogenesis， and activation of immune responses. Immunotherapy （including cell therapy， cytokine therapy， and immunosuppressive intervention）， hormone drugs， anticoagulant regimens， and traditional Chinese medicine therapies are commonly used in clinical practice to intervene in URSA， but the safety and effectiveness of some therapies are still controversial.
关键词
不明原因复发性流产发病机制治疗方法免疫
Keywords
pathogenesistherapiesimmune
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