Advances in effect mechanism research of traditional Chinese medicine on comorbid depressive symptoms in chronic pain

LIU Guanghua; SHI Dongliang; FU Wen; WANG Zihua; CUI Jiakang

doi:10.6039/j.issn.1001-0408.2024.19.20

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Advances in effect mechanism research of traditional Chinese medicine on comorbid depressive symptoms in chronic pain

更新时间：2024-10-11

- Advances in effect mechanism research of traditional Chinese medicine on comorbid depressive symptoms in chronic pain
- ZHONGGUO YAOFANG Vol. 35, Issue 19, Pages: 2438-2443(2024)
- 作者机构：
  
  1.河南中医药大学骨伤学院，郑州　450046
  2.河南中医药大学第二附属医院/河南省中医院骨伤病诊疗中心，郑州　450002
  3.河南中医药大学第一附属医院风湿免疫科，郑州　450014
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.19.20
  CLC： R965;R285
- Published：15 October 2024，
  
  Received：04 April 2024，
  
  Revised：15 August 2024，
- 稿件说明：
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刘光华,史栋梁,傅文等.中医药对慢性疼痛-抑郁共病的作用机制研究进展 ^Δ[J].中国药房,2024,35(19):2438-2443.

LIU Guanghua,SHI Dongliang,FU Wen,et al.Advances in effect mechanism research of traditional Chinese medicine on comorbid depressive symptoms in chronic pain[J].ZHONGGUO YAOFANG,2024,35(19):2438-2443.
刘光华,史栋梁,傅文等.中医药对慢性疼痛-抑郁共病的作用机制研究进展 ^Δ[J].中国药房,2024,35(19):2438-2443. DOI： 10.6039/j.issn.1001-0408.2024.19.20.

LIU Guanghua,SHI Dongliang,FU Wen,et al.Advances in effect mechanism research of traditional Chinese medicine on comorbid depressive symptoms in chronic pain[J].ZHONGGUO YAOFANG,2024,35(19):2438-2443. DOI： 10.6039/j.issn.1001-0408.2024.19.20.

摘要

慢性疼痛是指持续或反复发作时间超过3个月的疼痛，与抑郁、焦虑等情绪具有高共病率。慢性疼痛-抑郁共病的发病机制错综复杂，给临床诊疗带来极大困扰。本文综述了近年中药单体和复方以及针刺疗法对慢性疼痛-抑郁共病作用机制的研究进展，发现中药单体（黄酮类、酚类、萜类、香豆素类、生物碱类化合物）、中药复方（乌头汤、柴胡桂枝汤等）及针刺疗法（针刺“百会”“印堂”“合谷”“太冲”等穴位）可以通过调节中枢神经系统中神经递质、脑源性神经营养因子、炎症因子的水平以及神经胶质细胞的活性，有效改善慢性疼痛-抑郁共病。

Abstract

Chronic pain refers to pain that persists or recurs for more than 3 months and has a high comorbidity rate with emotions such as depression and anxiety. The complex pathogenesis of comorbid depressive symptoms in chronic pain poses great challenges to clinical diagnosis and treatment. This article reviews the research progress on the effect mechanism on the comorbid depressive symptoms in chronic pain by traditional Chinese medicine monomers， compound formulas， and acupuncture therapy in recent years. It is found that traditional Chinese medicine monomers （flavonoids， phenols， terpenes， coumarins， alkaloids）， traditional Chinese medicine formulas （

Aconitum carmichaeli

decoction， Chaihu guizhi decoction， etc.）， and acupuncture therapy （acupuncture at acupoints such as Baihui， Yintang， Hegu， and Taichong） can effectively improve comorbid depressive symptoms in chronic pain by regulating the levels of neurotransmitters， brain-derived neurotrophic factors and inflammatory factors， and the activity of glial cells in the central nervous system.

关键词

慢性疼痛-抑郁共病中药单体中药复方神经递质炎症作用机制

Keywords

traditional Chinese medicine monomertraditional Chinese medicine compound formulasneurotransmittersinflammationmechanism

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