Comparison of the efficacy and safety between the drug winning the bidding for centralized procurement and the original drug of ticagrelor in acute coronary syndrome patients after percutaneous coronary intervention

MIAO Yang; MENG Zhongru; QI Wang; ZHANG Dan; XU Kangshi; WANG Hongxia

doi:10.6039/j.issn.1001-0408.2024.20.14

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Comparison of the efficacy and safety between the drug winning the bidding for centralized procurement and the original drug of ticagrelor in acute coronary syndrome patients after percutaneous coronary intervention

更新时间：2024-10-25

- Comparison of the efficacy and safety between the drug winning the bidding for centralized procurement and the original drug of ticagrelor in acute coronary syndrome patients after percutaneous coronary intervention
- ZHONGGUO YAOFANG Vol. 35, Issue 20, Pages: 2522-2526(2024)
- 作者机构：
  
  1.南京大学医学院附属盐城第一医院/盐城市第一人民医院药学部，江苏盐城　224000
  2.南京大学医学院附属盐城第一医院/盐城市第一人民医院心血管内科，江苏盐城　224000
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2024.20.14
  CLC： R973+.2
- Published：30 October 2024，
  
  Received：18 July 2024，
  
  Revised：06 September 2024，
- 稿件说明：
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缪阳,孟中如,祁旺等.替格瑞洛集采中标药与原研药用于ACS患者 PCI后的疗效与安全性比较 ^Δ[J].中国药房,2024,35(20):2522-2526.

MIAO Yang,MENG Zhongru,QI Wang,et al.Comparison of the efficacy and safety between the drug winning the bidding for centralized procurement and the original drug of ticagrelor in acute coronary syndrome patients after percutaneous coronary intervention[J].ZHONGGUO YAOFANG,2024,35(20):2522-2526.
缪阳,孟中如,祁旺等.替格瑞洛集采中标药与原研药用于ACS患者 PCI后的疗效与安全性比较 ^Δ[J].中国药房,2024,35(20):2522-2526. DOI： 10.6039/j.issn.1001-0408.2024.20.14.

MIAO Yang,MENG Zhongru,QI Wang,et al.Comparison of the efficacy and safety between the drug winning the bidding for centralized procurement and the original drug of ticagrelor in acute coronary syndrome patients after percutaneous coronary intervention[J].ZHONGGUO YAOFANG,2024,35(20):2522-2526. DOI： 10.6039/j.issn.1001-0408.2024.20.14.

摘要

目的

比较替格瑞洛集采中标药与原研药用于急性冠脉综合征（ACS）患者经皮冠脉介入术（PCI）后1年的疗效与安全性。

方法

选择2021年7月至2023年6月我院收治的接受PCI的ACS患者420例，根据使用的替格瑞洛品种分为集采组（156例）和原研组（264例）。所有患者均规律服用阿司匹林肠溶片100 mg，每日1次；在此基础上，集采组患者给予集采中标的替格瑞洛片，原研组患者给予原研药替格瑞洛片，两组患者的用药剂量均为90 mg，每日2次，疗程均为12个月。比较两组患者治疗前及治疗1周后的血液常规指标，PCI后随访1年的净不良临床事件（NACE）、主要心脑血管不良事件（MACCE）、出血事件发生率和无MACCE及无出血事件生存率。

结果

两组患者治疗前及治疗1周后血液常规指标、PCI后随访1年的NACE、MACCE、出血事件发生率和无MACCE及无出血事件生存率比较，差异均无统计学意义（

＞0.05）。

结论

PCI后随访1年，替格瑞洛集采中标药的临床疗效和安全性与其原研药相当。

Abstract

OBJECTIVE

To compare the efficacy and safety between the drug winning the bidding for centralized procurement and the original drug of ticagrelor in acute coronary syndrome （ACS） patients one year after percutaneous coronary intervention （PCI）.

METHODS

Overall 420 ACS patients treated with PCI in our hospital from July 2021 to June 2023 were divided into centralized procurement group （156 cases） and original drug group （264 cases） according to the different varieties of ticagrelor. All patients were given Aspirin enteric-coated tablets 100 mg regularly， once a day； on this basis， patients in the centralized procurement group were given Ticagrelor tablets winning the bidding， while patients in the original drug group were given the original drug of Ticagrelor tablets. The dosage of Ticagrelor tablets taken by both groups of patients was 90 mg， twice a day， and the course of treatment was 12 months. The blood routine indicators were compared before treatment and one week after treatment， while the incidence of net adverse clinical events （NACE）， major adverse cardiovascular and cerebrovascular events （MACCE） and bleeding events， and the survival rate without MACCE and bleeding events during a one-year follow-up after PCI were also compared between two groups.

RESULTS

There were no statistically significant differences in blood r

outine indicators before treatment and one week after treatment， as well as the incidence of NACE， MACCE and bleeding events， survival rate without MACCE and bleeding events during a one-year follow-up after PCI between the two groups （

＞0.05）.

CONCLUSIONS

During a one-year follow-up after PCI， the efficacy and safety of the drug winning the bidding for centralized procurement of ticagrelor are comparable to the original drug.

关键词

替格瑞洛急性冠脉综合征经皮冠脉介入术仿制药原研药集中采购疗效安全性

Keywords

acute coronary syndromepercu-taneous coronary interventiongeneric drugoriginal drugcentralized procurementefficacysafety

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