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Investigation of the relationship between metformin and sarcopenia-related traits based on Mendelian randomization
- ZHONGGUO YAOFANG Vol. 35, Issue 22, Pages: 2793-2798(2024)
- 作者机构：
中国科学技术大学附属第一医院离子医学中心（合肥离子医学中心），合肥 230088
- 作者简介：
- 基金信息：
DOI：10.6039/j.issn.1001-0408.2024.22.16
CLC： R977.1+5;R969.3Published：30 November 2024，
Received：14 December 2023，
Revised：16 June 2024，
- 稿件说明：
移动端阅览
朱岳,鞠营辉,杨玉莹等.基于孟德尔随机化探讨二甲双胍与肌少症相关特征的关联[J].中国药房,2024,35(22):2793-2798.
ZHU Yue,JU Yinghui,YANG Yuying,et al.Investigation of the relationship between metformin and sarcopenia-related traits based on Mendelian randomization[J].ZHONGGUO YAOFANG,2024,35(22):2793-2798.
朱岳,鞠营辉,杨玉莹等.基于孟德尔随机化探讨二甲双胍与肌少症相关特征的关联[J].中国药房,2024,35(22):2793-2798. DOI： 10.6039/j.issn.1001-0408.2024.22.16.
ZHU Yue,JU Yinghui,YANG Yuying,et al.Investigation of the relationship between metformin and sarcopenia-related traits based on Mendelian randomization[J].ZHONGGUO YAOFANG,2024,35(22):2793-2798. DOI： 10.6039/j.issn.1001-0408.2024.22.16.
摘要
目的
2
探讨二甲双胍与肌少症相关特征的关联。
方法
2
基于公开的全基因组关联研究相关数据库，利用与二甲双胍使用强相关的单核苷酸多态性位点作为工具变量，采用两样本孟德尔随机化（MR）分析方法[包括逆方差加权（IVW）法、MR-Egger回归法和加权中位数法
]
研究二甲双胍与肌少症3种相关特征（低握力、肌肉质量、步行速度）的关联。分别采用Cochran’s
Q
检验评估异质性、MR-Egger截距检验检测多效性、留一法进行敏感性分析。
结果
2
IVW法分析结果显示，二甲双胍的使用可能与低握力风险增加（
β
＝1.550，95%CI为0.389～2.711，
P
＝0.009）和四肢肌肉质量减少（右腿瘦体重：
β
＝－0.665，95%CI为－1.018～－0.312，
P
＜0.001；左腿瘦体重：
β
＝－0.710，95%CI为－1.049～－0.371，
P
＜0.001；右臂瘦体重：
β
＝－0.471，95%CI为－0.890～－0.053，
P
＝0.027；左臂瘦体重：
β
＝－0.463，95%CI为－0.865～－0.061，
P
＝0.024）存在显著关联，但与步行速度无关。其他2种方法的结果或因果效应方向与之一致。Cochran’s
Q
检验提示本研究结果存在一定异质性；MR-Egger截距检验未发现水平多效性；敏感性分析提示本研究结果具有稳健性。
结论
2
二甲双胍可能增加肌少症的风险。
Abstract
OBJECTIVE
2
To investigate the relationship between metformin and sarcopenia-related traits.
METHODS
2
Based on the data from publicly genome-wide association study-related databases， using single nucleotide polymorphisms strongly associated with metformin as instrumental variables， the two-sample Mendelian randomization （MR） analysis methods [inverse variance weighting （IVW） method， MR-Egger regression method and weighted median estimator method
]
were employed to investigate the relationship between metformin and three sarcopenia-related traits （low grip strength， muscle mass and walking speed）. Cochran’s
Q
test was used to assess heterogeneity， MR-Egger intercept test was used to detect horizontal pleiotropy， and leave-one-out analysis was performed for sensitivity analysis.
RESULTS
2
The results of IVW method showed that metformin use was significantly associated with an increased risk of low grip strength （
β
＝1.550， 95%CI was 0.389-2.711，
P
＝0.009） and reduced limb muscle mass （right leg lean body mass：
β
＝－0.665， 95%CI was －1.018-－0.312，
P
＜0.001； left leg lean body mass：
β
＝－0.710， 95%CI was －1.049-－0.371，
P
＜0.001； right arm lean body mass：
β
＝－0.471， 95%CI was －0.890-－0.053，
P
＝0.027； left arm lean body mass：
β
＝－0.463， 95%CI was －0.865-－0.061，
P
＝0.024），but was not associated with walking speed. The results or causal effects of the other two methods are consistent with it. The Cochran’s
Q
test indicated some degree of heterogeneity in the result of this study. No horizontal pleiotropy was detected by the MR-Egger intercept test. The sensitivity analysis suggested that the results of this study were stable.
CONCLUSIONS
2
Metformin may increase the risk of sarcopenia.
关键词
孟德尔随机化二甲双胍肌少症低握力肌肉质量关联分析
Keywords
metforminsarcopenialow grip strengthmuscle massrelationship analysis
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