Research progress on drug delivery by ophthalmic microneedle

LIU Han; ZHANG Lanyue; SHEN Qiang; PENG Xiaojing

doi:10.6039/j.issn.1001-0408.2025.03.19

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Research progress on drug delivery by ophthalmic microneedle

更新时间：2025-02-10

- Research progress on drug delivery by ophthalmic microneedle
- ZHONGGUO YAOFANG Vol. 36, Issue 3, Pages: 367-372(2025)
- 作者机构：
  
  1.重庆大学附属江津医院眼科，重庆　402260
  2.重庆大学附属江津医院肾脏与风湿免疫科，重庆　402260
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.03.19
  CLC： R988.1;R943
- Published：15 February 2025，
  
  Received：18 July 2024，
  
  Revised：25 December 2024，
  
  Accepted：2025-01-14
- 稿件说明：
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刘涵,张蓝月,沈强等.眼科微针药物递送的研究进展 ^Δ[J].中国药房,2025,36(03):367-372.

LIU Han,ZHANG Lanyue,SHEN Qiang,et al.Research progress on drug delivery by ophthalmic microneedle[J].ZHONGGUO YAOFANG,2025,36(03):367-372.
刘涵,张蓝月,沈强等.眼科微针药物递送的研究进展 ^Δ[J].中国药房,2025,36(03):367-372. DOI： 10.6039/j.issn.1001-0408.2025.03.19.

LIU Han,ZHANG Lanyue,SHEN Qiang,et al.Research progress on drug delivery by ophthalmic microneedle[J].ZHONGGUO YAOFANG,2025,36(03):367-372. DOI： 10.6039/j.issn.1001-0408.2025.03.19.

摘要

由于眼部存在生理屏障（包括外眼屏障和内眼屏障），使得常规眼科用药（滴眼液、眼膏、凝胶等）的生物利用度低，且到达眼后节困难。玻璃体注射虽然能使药物到达眼后节，但存在感染、损伤以及患者耐受性差等缺点。眼用微针突破了眼内外屏障，使药物能够精准到达治疗部位并能持续释放，很大程度地避免了眼内感染和损伤，提高了药物的生物利用度，作为眼部药物输送工具存在着明显的优势。眼用微针按使用方法可分为空心微针、可溶性微针和涂层微针。3种微针各具优势，在治疗细菌性和真菌性角膜炎、青光眼、渗出性老年性黄斑变性、糖尿病性黄斑水肿、非感染性葡萄膜炎、角膜新生血管甚至脉络膜黑色素瘤等疾病方面都有令人满意的表现。

Abstract

The presence of physiological barriers in the eye （both external and internal） makes conventional ophthalmic medications （eye drops， ointments， gels， etc.） less bioavailable and difficult to reach the posterior segment of the eye. Although intravitreal injection can deliver drugs to the posterior segment of the eye， it has disadvantages such as infection， injury， and poor tolerance. Ophthalmic microneedle breaks through the intra- and extra-ocular barriers， enabling the drug to reach the target site accurately and to be released continuously greatly avoiding intraocular infections and injuries， and improving the bioavailability of the drug， which has obvious advantages as an ophthalmic drug delivery tool. Ophthalmic microneedle can be classified into hollow microneedle， dissolving microneedle， and coated microneedle according to the usage methods. Each type of microneedle has its own advantages and has shown satisfactory performance in the treatment of diseases such as bacterial and fungal keratitis， glaucoma， exudative age-related macular degeneration， diabetic macular edema， non-infectious uveitis， corneal neovascularization， and even choroidal melanoma.

关键词

微针药物递送眼科用药细菌性角膜炎真菌性角膜炎青光眼渗出性老年性黄斑变性糖尿病性黄斑水肿非感染性葡萄膜炎

Keywords

drug deliveryophthalmic medicationbacterial keratitisfungal keratitisglaucomaexudative age-related macular degenerationdiabetic macular edemanon-infectious uveitis

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