Research advances on traditional Chinese medicine monomers and compounds intervening in ankylosing spondylitis-related signaling pathways

ZHOU Haidong; LU Yaohong; HU Liangshen; GONG Li; LIN Maohua; HAO Shipeng; YAN Jianbin; CHEN Weihui; FAN Shaoyong

doi:10.6039/j.issn.1001-0408.2025.03.20

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Research advances on traditional Chinese medicine monomers and compounds intervening in ankylosing spondylitis-related signaling pathways

更新时间：2025-02-10

- Research advances on traditional Chinese medicine monomers and compounds intervening in ankylosing spondylitis-related signaling pathways
- ZHONGGUO YAOFANG Vol. 36, Issue 3, Pages: 373-378(2025)
- 作者机构：
  
  1.江西中医药大学临床医学院，南昌　330004
  2.江西中医药大学附属洪都中医院运动医学科，南昌　330038
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.03.20
  CLC： R965;R285
- Published：15 February 2025，
  
  Received：23 August 2024，
  
  Revised：09 January 2025，
  
  Accepted：2025-01-09
- 稿件说明：
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周海东,卢姚宏,胡梁深等.中药单体和复方干预强直性脊柱炎的相关信号通路研究进展 ^Δ[J].中国药房,2025,36(03):373-378.

ZHOU Haidong,LU Yaohong,HU Liangshen,et al.Research advances on traditional Chinese medicine monomers and compounds intervening in ankylosing spondylitis-related signaling pathways[J].ZHONGGUO YAOFANG,2025,36(03):373-378.
周海东,卢姚宏,胡梁深等.中药单体和复方干预强直性脊柱炎的相关信号通路研究进展 ^Δ[J].中国药房,2025,36(03):373-378. DOI： 10.6039/j.issn.1001-0408.2025.03.20.

ZHOU Haidong,LU Yaohong,HU Liangshen,et al.Research advances on traditional Chinese medicine monomers and compounds intervening in ankylosing spondylitis-related signaling pathways[J].ZHONGGUO YAOFANG,2025,36(03):373-378. DOI： 10.6039/j.issn.1001-0408.2025.03.20.

摘要

强直性脊柱炎是一种以脊柱和骶髂关节为主要受累部位的慢性免疫炎症性疾病，与骨保护素（OPG）/核因子κB（NF-κB）受体激活因子（RANK）/RANK配体、促分裂原活化的蛋白质激酶（MAPK）、Wnt/

-连环蛋白（

-catenin）、磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白（PI3K/Akt/mTOR）等信号通路密切相关。中药具有多成分、多靶点的特点，因其毒性低、特异性强、疗效高而被广泛应用于自身免疫性疾病的治疗。本文综述发现，中药单体和复方可通过干预上述信号通路，调节免疫炎症反应，抑制骨破坏、异位成骨分化、细胞凋亡和自噬等生物学过程发挥抗强直性脊柱炎的作用。

Abstract

Ankylosing spondylitis is a chronic immunoinflammatory disease that mainly affects the spine and the sacroiliac joint， the mechanism of which is closely related to signaling pathways， such as osteoprotegerin （OPG）/receptor activator of nuclear factor-κB （RANK）/RANK ligand， mitogen-activated protein kinase （MAPK）， Wnt/

-catenin （

-catenin）， phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin （PI3K/Akt/mTOR）. Traditional Chinese medicine has the characteristics of multiple components and targets， and is widely used for the treatment of autoimmune diseases due to its low toxicity， strong specificity， and high efficacy. This review found that monomers and compounds of traditional Chinese medicine can exert anti ankylosing spondylitis effects by intervening in the aforementioned signaling pathways， regulating immune inflammatory responses， and inhibiting biological processes such as bone destruction， ectopic osteogenic differentiation， cell apo

ptosis， and autophagy.

关键词

中药复方单体强直性脊柱炎信号通路免疫

Keywords

compoundmonomerankylosing spondylitissignaling pathwayimmune

references

GOLDER V，SCHACHNA L. Ankylosing spondylitis：an update[J]. Aust Fam Physician，2013，42（11）：780-784.

ZHANG S Z，PENG L Y，LI Q Y，et al. Spectrum of spondyloarthritis among Chinese populations[J]. Curr Rheumatol Rep，2022，24（8）：247-258.

ZHAO J L，HUANG C Y，HUANG H T，et al. Prevalence of ankylosing spondylitis in a Chinese population：a systematic review and meta-analysis[J]. Rheumatol Int，2020，40（6）：859-872.

HARRISON S R，MARZO-ORTEGA H. Have therapeutics enhanced our knowledge of axial spondyloarthritis?[J]. Curr Rheumatol Rep，2023，25（3）：56-67.

WAN R H，JI Y，FAN Y H，et al. Efficacy and safety of Duhuo jisheng decoction combined with Western medicine in the treatment of ankylosing spondylitis：a systematic review and meta-analysis[J]. Complement Ther Clin Pract，2023，51：101739.

RAYCHAUDHURI S P，SHAH R J，BANERJEE S，et al. JAK-STAT signaling and beyond in the pathogenesis of spondyloarthritis and their clinical significance[J]. Curr Rheumatol Rep，2024，26（6）：204-213.

YANG L Y，WU Y S，LIN S H，et al. sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38 MAPK/mTOR/ULK1ser757 signaling pathway[J]. FASEB J，2021，35（2）：e21170.

LIU Z，MIN S，LU X，et al. Hyperactivation of PI3K/Akt/mTOR signal pathway impairs TNF-α-induced autophagy in mesenchymal stem cells from patients with ankylosing spondylitis[J]. J South Med Univ，2022，42（2）：272-277.

DE LEON-OLIVA D，BARRENA-BLÁZQUEZ S，JIMÉNEZ-ÁLVAREZ L，et al. The RANK-RANKL-OPG system：a multifaceted regulator of homeostasis，immunity，and cancer[J]. Medicina （Kaunas），2023，59（10）：1752.

QIAN B P，WANG X Q，QIU Y，et al. Association of receptor activator of nuclear factor-kappaB ligand （RANKL） gene polymorphisms with the susceptibility to ankylosing spondylitis：a case-control study[J]. J Orthop Sci，2014，19（2）：207-212.

CHEN C H，CHEN H G，LIAO H T，et al. Soluble receptor activator of nuclear factor-kappaB ligand （RANKL） and osteoprotegerin in ankylosing spondylitis：OPG is associated with poor physical mobility and reflects systemic inflammation[J]. Clin Rheumatol，2010，29（10）：1155-1161.

WGOLDER V，SCHACHNA L. Ankylosing spondylitis：an update[J]. Aust Fam Physician，2013，42（11）：780-784.

LIU J Q，XIAO Q，XIAO J N，et al. Wnt/β-catenin signa- ling：function，biological mechanisms，and therapeutic opportunities[J]. Signal Transduct Target Ther，2022， 7（1）：3.

CICI D，CORRADO A，ROTONDO C，et al. Wnt signa- ling and biological therapy in rheumatoid arthritis and spondyloarthritis[J]. Int J Mol Sci，2019，20（22）：5552.

LIU R，ZHANG X，JIANG G M，et al. Gene-gene interaction and association of Wnt/β-catenin signaling pathway gene polymorphisms with ankylosing spondylitis susceptibility in the Chinese Han population[J]. Autoimmunity，2019，52（7/8）：281-288.

LAI B，WU C H，LAI J H. Activation of c-Jun N-terminal kinase，a potential therapeutic target in autoimmune arthritis[J]. Cells，2020，9（11）：2466.

SU J M，CUI L F，YANG W H，et al. Baseline high-sensitivity C-reactive protein predicts the risk of incident ankylosing spondylitis：results of a community-based prospective study[J]. PLoS One，2019，14（2）：e0211946.

XIE J L，XU J R，CHEN H Y. Regulatory mechanisms of miR-212-3p on the secretion of inflammatory factors in monocyte-macrophages and the directed differentiation into osteoclasts in ankylosing spondylitis[J]. Aging （Albany NY），2023，15（22）：13411-13421.

XUE C，YAO Q F，GU X Y，et al. Evolving cognition of the JAK-STAT signaling pathway：autoimmune disorders and cancer[J]. Signal Transduct Target Ther，2023，8（1）：204.

SHAH R J，BANERJEE S，RAYCHAUDHURI S，et al. JAK-STAT inhibitors in immune mediated diseases：an overview[J]. Indian J Dermatol Venereol Leprol，2023，89（5）：691-699.

CHEN C，ZHANG X S，WANG Y. Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population[J]. Clin Immunol，2010，136（3）：442-446.

DEODHAR A，SLIWINSKA-STANCZYK P，XU H J， et al. Tofacitinib for the treatment of ankylosing spondylitis：a phase Ⅲ，randomised，double-blind，placebo-controlled study[J]. Ann Rheum Dis，2021，80（8）：1004-1013.

JO S，WON E J，KIM M J，et al. STAT3 phosphorylation inhibition for treating inflammation and new bone formation in ankylosing spondylitis[J]. Rheumatology （Oxford），2021，60（8）：3923-3935.

DAI W B，HE Y F，KAI L. SPI1 regulates the progression of ankylosing spondylitis by modulating TLR5 via NF-κB signaling[J]. Inflammation，2023，46（5）：1697-1708.

DING M N，CHO E，CHEN Z H，et al. （S）-2-（cyclobutylamino）-N-（3-（3，4-dihydroisoquinolin-2（1H）-yl）-2-hydroxypropyl） isonicotinamide attenuates RANKL-induced osteoclast differentiation by inhibiting NF-κB nuclear translocation[J]. Int J Mol Sci，2023，24（5）：4327.

FENG X Z，ZHU S B，QIAO J J，et al. CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation through NF-κB signaling pathway in ankylosing spondylitis in vitro[J]. J Transl Med，2023，21（1）：573.

YAO X W，LIU H D，REN M X，et al. Aloe polysaccharide promotes osteogenesis potential of adipose-derived stromal cells via BMP-2/Smads and prevents ovariectomized-induced osteoporosis[J]. Mol Biol Rep，2022，49（12）：11913-11924.

JIANG N，LIU H X，LIANG H Y，et al. Osteogenic differentiation characteristics of hip joint capsule fibroblasts obtained from patients with ankylosing spondylitis[J]. Ann Transl Med，2021，9（4）：331.

丁香，刘健，陈晓露，等. 雷公藤甲素通过miR-23a-3p/PTEN/PI3K/Akt/mTOR改善强直性脊柱炎滑膜成纤维细胞作用机制[J]. 中华中医药杂志，2023，38（12）：6024-6029.

DING X，LIU J，CHEN X L，et al. Triptolide improving mechanism of action of ankylosing spondylitis synovial fibroblasts through miR-23a-3p/PTEN/PI3K/Akt/mTOR[J]. China J Tradit Chin Med Pharm，2023，38（12）：6024-6029.

龙琰. 健脾化湿通络法改善强直性脊柱炎患者心功能的数据挖掘及对miR-23a-3p/PTEN/PI3K/Akt/mTOR的影响[D].合肥：安徽中医药大学，2022.

LONG Y. Data mining and the effect of miR-23a-3p/PTEN/PI3K/Akt/mTOR signal pathway in the treatment of ankylosing spondylitis accompanying with cardiac function by invigorating the spleen，removing dampness and dredging collaterals[D].Hefei：Anhui University of Chinese Medicine，2022.

叶文芳，刘健，万磊，等. 新风胶囊对强直性脊柱炎患者疗效及血清免疫球蛋白亚型、外周血淋巴细胞自噬的影响[J]. 中国中西医结合杂志，2016，36（3）：310-316.

YE W F，LIU J，WAN L，et al. Effect of Xinfeng capsule on AS patients and their serum immunoglobulin subtypes and peripheral lymphocyte autophagy[J]. Chin J Integr Tradit West Med，2016，36（3）：310-316.

丁繁荣. 清热舒督汤治疗活动期强直性脊柱炎临床疗效观察及其作用机制的研究[D]. 济南：山东中医药大学，2020.

DING F R. Clinical observation of Qingre shudu decoction in the treatment of active ankylosing spondylitis and its mechanism[D]. Jinan：Shandong University of Traditional Chinese Medicine，2020.

徐波，徐蕾. 阳和汤加减对强直性脊柱炎小鼠RANKL系统表达的影响[J]. 中医药临床杂志，2018，30（10）：1844-1846.

XU B，XU L. Effect of modified Yanghe decoction on RANKL system expression in ankylosing spondylitis mice[J]. Clin J Tradit Chin Med，2018，30（10）：1844-1846.

马丽瑶. 益肾蠲痹法对强直性脊柱炎骨丢失调控的临床和实验研究[D].杭州：浙江中医药大学，2023.

MA L Y.Chical research of the effects of serum containing Yishen juanbi decoction on bone loss of ankylosing spondylitis[D].Hangzhou：Zhejiang University of Traditional Chinese Medicine，2023.

李灿，刘丹，罗常春，等. 壮督驱寒合剂对强直性脊柱炎模型小鼠miR-29a及Wnt信号通路的影响[J]. 陕西中医，2020，41（8）：1038-1041.

LI C，LIU D，LUO C C，et al. Effects of Zhuangdu quhan mixture on miR-29a and Wnt pathway in the ankylosing spondylitis model mice[J]. Shaanxi J Tradit Chin Med，2020，41（8）：1038-1041.

李艳萍. 补肾强督方干预强直性脊柱炎病理性新骨形成的实验研究[D]. 北京：北京中医药大学，2019.

LI Y P. Experimental study on the intervention of Bushen qiangdu recipe on pathological new bone formation in ankylosing spondylitis[D]. Beijing：Beijing University of Chinese Medicine，2019.

郑家春，熊正罡，赵洋洋，等. 丹皮酚对强直性脊柱炎小鼠跟腱滑膜的影响[J]. 中国矫形外科杂志，2021，29（11）：1019-1023.

ZHENG J C，XIONG Z G，ZHAO Y Y，et al. Effects of paeonol on Achilles tendon and synovium in ankylosing spondylitis mouse model[J]. Orthop J China，2021，29（11）：1019-1023.

LI J X，CHEN Z X，LIAO H B，et al. Anti-osteogenic effect of danshensu in ankylosing spondylitis：an in vitro study based on integrated network pharmacology[J]. Front Pharmacol，2021，12：772190.

徐晓涵，刘宏潇，屈馨宁，等. 基于网络药理学及实验验证探讨淫羊藿苷干预强直性脊柱炎的分子机制[J]. 中国中医基础医学杂志，2024，30（3）：1019-1023.

XU X H，LIU H X，QU X N，et al. Exploration of the molecular mechanism of icariin intervention in ankylosing spondylitis based on network pharmacology and experimental verification[J]. Chin J Basic Med Tradit Chin Med，2024，30（3）：1019-1023.

尚娟. 加味愈痛丸治疗强直性脊柱炎疗效观察及对血清JAK/STAT信号通路的影响[J]. 新中医，2023，55（21）：77-82.

SHANG J. Effect of modified Yutong pills on ankylosing spondylitis and its influence on serum JAK/STAT signaling pathway[J]. J New Chin Med，2023，55（21）：77-82.

DING M H，XU P G，WANG Y，et al. Resveratrol atte- nuates ankylosing spondylitis in mice by inhibiting the TLR4/NF-κB/NLRP3 pathway and regulating gut microbiota[J]. Immunol Invest，2023，52（2）：194-209.

SONG C Y，WANG K Y，QIAN B P，et al. Nrf-2/ROS/NF-κB pathway is modulated by cynarin in human mesenchymal stem cells in vitro from ankylosing spondylitis[J]. Clin Transl Sci，2024，17（3）：e13748.

WANG G L，CAI J，ZHANG J S，et al. Mechanism of triptolide in treating ankylosing spondylitis through the anti-ossification effect of the BMP/Smad signaling pathway[J]. Mol Med Rep，2018，17（2）：2731-2737.

ZHOU Y Y，LIU H X，JIANG N，et al. Elemene，the essential oil of Curcuma wenyujin，inhibits osteogenic diffe- rentiation in ankylosing spondylitis[J]. Joint Bone Spine，2015，82（2）：100-103.

LIU H X，JIANG N，LIANG H Y，et al. Bushen qiangji granule medicated serum inhibits osteogenic differentiation of fibroblasts in ankylosing spondylitis by inhibiting the BMP/Smads signal pathway in vitro[J]. Chin J Integr Med，2016，22（11）：817-822.

MAURO D，THOMAS R，GUGGINO G，et al. Ankylosing spondylitis：an autoimmune or autoinflammatory disease?[J]. Nat Rev Rheumatol，2021，17（7）：387-404.

ZHU W，HE X X，CHENG K Y，et al. Ankylosing spondylitis：etiology，pathogenesis，and treatments[J]. Bone Res，2019，7：22.

KLAVDIANOU K，TSIAMI S，BARALIAKOS X. New developments in ankylosing spondylitis-status in 2021[J]. Rheumatology （Oxford），2021，60（Suppl. 6）：Ⅵ29-Ⅵ37.

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