Study on toxicity-reducing and efficacy-enhancing effects of <italic style="font-style: italic">Polygala tenuifolia</italic> compatibility on sand-ironing <italic style="font-style: italic">Strychnos nux-vomica</italic>

SUI Yi; FENG Guo; LIU Gang; LIU Keyan; WEI Xuehao; TENG Minggang; LI Wei; HAN Caiyao; LEI Yan

doi:10.6039/j.issn.1001-0408.2025.10.08

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Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sand-ironing Strychnos nux-vomica

更新时间：2025-09-23

- Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sand-ironing Strychnos nux-vomica
- ZHONGGUO YAOFANG Vol. 36, Issue 10, Pages: 1197-1201(2025)
- 作者机构：
  
  1.贵州中医药大学药学院，贵阳　550025
  2.贵州中药炮制技术传承基地，贵阳　550025
  3.道地药材国家重点实验室，北京　100700
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.10.08
  CLC： R285.5;R917
- Received：16 October 2024，
  
  Revised：2025-04-01，
  
  Accepted：02 April 2025，
  
  Published：30 May 2025
- 稿件说明：
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隋怡,冯果,刘刚,等.远志配伍对砂烫马钱子的减毒增效作用研究 [J].中国药房,2025,36(10):1197-1201.

SUI Yi,FENG Guo,LIU Gang,et al.Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sand-ironing Strychnos nux-vomica[J].ZHONGGUO YAOFANG,2025,36(10):1197-1201.
隋怡,冯果,刘刚,等.远志配伍对砂烫马钱子的减毒增效作用研究 [J].中国药房,2025,36(10):1197-1201. DOI： 10.6039/j.issn.1001-0408.2025.10.08.

SUI Yi,FENG Guo,LIU Gang,et al.Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sand-ironing Strychnos nux-vomica[J].ZHONGGUO YAOFANG,2025,36(10):1197-1201. DOI： 10.6039/j.issn.1001-0408.2025.10.08.

摘要

目的

探究远志配伍对砂烫马钱子（简称“砂马”）毒性和抗炎、镇痛药效的影响。

方法

制备砂马单煎液、砂马-去芯远志1∶2.5或1∶5共煎液[简称“砂马远志（1∶2.5）共煎液”或“砂马远志（1∶5）共煎液”

]

和砂马-去芯远志（1∶5）混合液[简称“砂马远志（1∶5）混合液”

]

，考察其半数致死剂量（LD

）；以阿司匹林为阳性对照，比较上述药液致小鼠扭体次数、镇痛率、疼痛潜伏期、耳肿胀度、炎症抑制率的不同；检测上述药液中活性兼毒性成分士的宁、马钱子碱的含量。

结果

砂马单煎液、砂马远志（1∶2.5）共煎液、砂马远志（1∶5）共煎液、砂马远志（1∶5）混合液的LD

分别为302.00、614.47、1 445.44、1 778.28 mg/kg；上述药液组小鼠的扭体次数、耳肿胀度均较对照组显著减少或降低（

＜0.05或

＜0.01），疼痛潜伏期[砂马单煎液组90、120 min时，砂马远志（1∶2.5）共煎液组60、90 min时以及砂马远志（1∶5）共煎液组和砂马远志（1∶5）混合液组60、90、120 min时

]

均较对照组显著延长（

＜0.05或

＜0.01）；各药液的镇痛率分别为39.30%、70.87%、80.00%、82.46%，炎症抑制率分别为38.08%、57.89%、76.47%、50.46%，且共煎液、混合液的镇痛、抗炎效果普遍优于单煎液（

＜0.05或

＜0.01）。上述4种药液中，士的宁的总含量分别为0.71%、0.42%、0.47%、0.64%，马钱子碱的总含量分别为0.88%、0.63%、0.57%、0.88%。

结论

远志配伍能减轻砂马的毒性，并可增强砂马的抗炎、镇痛活性，其增效减毒作用有随远志用量增加而增强的趋势；且两者共煎可降低砂马中活性兼毒性成分士的宁、马钱子碱的含量。

Abstract

OBJECTIVE

To explore the effects of

Polygala tenuifolia

compatibility on toxicity， anti-inflammatory and analgesic efficacy of sand-ironing

Strychnos nux-vomica

（SS）.

METHODS

The preparation of SS single decoction， SS-

P. tenuifolia

core-removed （PC）（1∶2.5） or （1∶5） combined decoction， and SS-PC （1∶5） mixture were carried out to investigate their median lethal dose （LD

）. Using aspirin as positive control， the number of writhing movements， analgesic rate， pain latency， ear swelling degree and inflammation inhibition rate induced by the above-mentioned medicinal liquids in mice were compared. The contents of the active and toxic components， strychnine and brucine， in the above-mentioned medicinal liquids were also determined.

RESULTS

The LD

values of SS single decoction， SS-PC （1∶2.5） combined decoction， SS-PC （1∶5） combined decoction and SS-PC （1∶5） mixture were 302.00， 614.47， 1 445.44 and 1 778.28 mg/kg， respectively. Compared with control group， the number of writhing movements and ear swelling degree in the mice of the above-mentioned medicinal liquid groups were reduced or decreased significantly （

＜0.05 or

＜0.01）； pain latency [at 90 and 120 minutes in the SS single decoction group， at 60 and 90 minutes in the SS-PC （1∶2.5） combined decoction group， and at 60，90，120 minutes in the SS-PC （1∶5） combined decoction group and SS-PC （1∶5） mixture group

]

was significantly prolonged （

＜0.05 or

＜0.01）； analgesic rates of the respective medicinal liquids were 39.30%， 70.87%， 80.00% and 82.46%， and inflammation inhibition rates were 38.08%， 57.89%， 76.47% and 50.46%； analgesic and anti-inflammatory effects of combined decoction and mixture were generally be

tter than those of the single decoction （

＜0.05 or

＜0.01）. In the above-mentioned four medicinal liquids， the total contents of strychnine were 0.71%， 0.42%， 0.47% and 0.64%， and the total contents of brucine were 0.88%， 0.63%， 0.57% and 0.88%， respectively.

CONCLUSIONS

The combination of

P. tenuifolia

can reduce the toxicity of SS and enhance its anti-inflammatory and analgesic effects. Moreover， there is a tendency for the toxicity-reducing and efficacy-enhancing effects to increase with the increasing dosage of

P. tenuifolia

. Additionally， the combined decoction of SS and

P. tenuifolia

can reduce the contents of the active and toxic components， strychnine and brucine， in SS.

关键词

Keywords

references

国家药典委员会 . 中华人民共和国药典：一部 [M ] . 2020年版 . 北京：中国医药科技出版社， 2020 ： 52 - 53 .

秦贝贝，贾泽菲，王佳莉，等 . 马钱子化学成分和药理作用的研究进展及其质量标志物（Q-Marker）预测分析 [J ] . 中草药， 2022 ， 53 （ 18 ）： 5920 - 5933 .

郑传奇，冯果，李玮，等 . 苗药了哥王“汗渍法” 炮制前后抗小鼠免疫性炎症的“量-效-毒”关系研究 [J ] . 中国药房， 2020 ， 31 （ 6 ）： 661 - 665 .

闫静，甄晓宇，刘志强，等 . 配伍延胡索对马钱子毒性影响的实验研究 [J ] . 中华中医药杂志， 2020 ， 35 （ 7 ）： 3690 - 3694 .

王一鸣，张宏伟，张红伟，等 . HPLC特征图谱及指标成分含量测定比较不同煮制时间绿豆煮马钱子成分变化 [J ] . 中华中医药杂志， 2024 ， 39 （ 2 ）： 882 - 886 .

李永丰，任维 . 马钱子碱通过钾离子通道调节外周镇痛 [J ] . 中国疼痛医学杂志， 2019 ， 25 （ 2 ）： 94 - 101 .

郭玉岩，马文保，肖洪彬，等 . 基于UPLC-MS技术分析马钱子-甘草药对配伍汤液不同相态中毒效物质的变化规律 [J ] . 中草药， 2017 ， 48 （ 23 ）： 4880 - 4884 .

LEE C I ， HAN J Y ， HONG J T ， et al . 3，4，5-trimethoxycinnamic acid（TMCA），one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping beha-viors via GABAAergic systems in mice [J ] . Arch Pharm Res ， 2013 ， 36 （ 10 ）： 1244 - 1251 .

CHATTIPAKORN S C ， MCMAHON L L . Strychnine-sensitive glycine receptors depress hyperexcitability in rat dentate gyrus [J ] . J Neurophysiol ， 2003 ， 89 （ 3 ）： 1339 - 1342 .

刘屏，王东晓，郭代红，等 . 远志3，6′-二芥子酰基蔗糖在药物诱发抑郁模型上的药效评价 [J ] . 中国药学杂志， 2008 ， 43 （ 18 ）： 1391 - 1394 .

尤启东 . 药物化学 [M ] . 4版 . 北京：化学工业出版社， 2015 ： 121 .

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Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sand-ironing Strychnos nux-vomica

DOI：10.6039/j.issn.1001-0408.2025.10.08

摘要

Abstract

关键词

Keywords

references