Research progress on the action mechanism of monomer components and compound formulations of traditional Chinese medicine in the treatment of vitiligo

FANG Gaoge; WANG Tong; NI Qianyue; WANG Yuanhong

doi:10.6039/j.issn.1001-0408.2025.10.21

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Research progress on the action mechanism of monomer components and compound formulations of traditional Chinese medicine in the treatment of vitiligo

更新时间：2025-05-23

- Research progress on the action mechanism of monomer components and compound formulations of traditional Chinese medicine in the treatment of vitiligo
- ZHONGGUO YAOFANG Vol. 36, Issue 10, Pages: 1271-1276(2025)
- 作者机构：
  
  1.黑龙江中医药大学第一临床医学院，哈尔滨　150006
  2.黑龙江中医药大学附属第一医院皮肤科，哈尔滨　150040
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.10.21
  CLC： R285;R758.4+1
- Received：22 October 2024，
  
  Revised：07 April 2025，
  
  Accepted：17 April 2025，
  
  Published：30 May 2025
- 稿件说明：
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房高鸽,王通,倪乾越等.中药单体及复方治疗白癜风的作用机制研究进展 ^Δ[J].中国药房,2025,36(10):1271-1276.

FANG Gaoge,WANG Tong,NI Qianyue,et al.Research progress on the action mechanism of monomer components and compound formulations of traditional Chinese medicine in the treatment of vitiligo[J].ZHONGGUO YAOFANG,2025,36(10):1271-1276.
房高鸽,王通,倪乾越等.中药单体及复方治疗白癜风的作用机制研究进展 ^Δ[J].中国药房,2025,36(10):1271-1276. DOI： 10.6039/j.issn.1001-0408.2025.10.21.

FANG Gaoge,WANG Tong,NI Qianyue,et al.Research progress on the action mechanism of monomer components and compound formulations of traditional Chinese medicine in the treatment of vitiligo[J].ZHONGGUO YAOFANG,2025,36(10):1271-1276. DOI： 10.6039/j.issn.1001-0408.2025.10.21.

摘要

白癜风是一种发病机制复杂的慢性难治性色素脱失性皮肤病。中药治疗白癜风具有多成分、多靶点的优势，临床疗效确切。本文对中药单体及复方治疗白癜风的作用机制进行归纳总结，发现球松素、刺蒺藜苷、二至丸等可通过激活环腺苷酸/蛋白激酶A（cAMP/PKA）信号通路，大麻二酚、丹参酮ⅡA可通过激活p38丝裂原激活的蛋白激酶（p38 MAPK）信号通路，银杏叶提取物EGb761、黄芪甲苷Ⅳ可通过激活芳香烃受体（AhR）信号通路，七叶皂苷、补骨脂素衍生物BSP-1等可通过激活Wnt/

-连环蛋白（Wnt/

-catenin）信号通路，芹菜素、白斑冲剂等可通过激活核因子E2相关因子2/血红素加氧酶1（Nrf2/HO-1）信号通路，金丝桃苷、山柰酚等可通过激活磷脂酰肌醇3-激酶/蛋白激酶B（PI3K/Akt）信号通路，如意黑白散可通过激活程序性死亡受体1/程序性死亡受体配体1（PD-1/PD-L1）信号通路，复方红花补蒺颗粒剂、去甲泽拉木醛等可通过抑制Janus激酶/信号转导及转录激活蛋白（JAK/STAT）信号通路，从而促进黑色素生成和沉着，减轻氧化应激、抑制自身免疫对黑色素细胞的破坏，减少黑色素细胞凋亡，进而发挥治疗白癜风的作用。

Abstract

Vitiligo is a chronic and refractory pigmentary loss skin disease with a complex pathogenesis. Traditional Chinese medicine（TCM） offers advantages in treating vitiligo， such as multi-component and multi-target effects， delivering definite

clinical efficacy. This article summarizes the action mechanisms of TCM monomer components and compound formulations in the treatment of vitiligo. It is found that pinostrobin， tribuloside and Erzhi pills can activate the cyclic adenosine monophosphate/protein kinase A（cAMP/PKA） signaling pathway； cannabidiol and tanshinone ⅡA can activate the p38 mitogen-activated protein kinase（p38 MAPK）signaling pathway；

Ginkgo biloba

extract EGb761 and astragaloside Ⅳ can activate the aryl hydrocarbon receptor（AhR）signaling pathway； escin and psoralen derivative BSP-1 can activate the Wnt/

-catenin signaling pathway； apigenin and Baiban granules can activate the nuclear factor erythroid 2-related factor 2/heme oxygenase-1（Nrf2/HO-1） signaling pathway； hyperoside and kaempferol can activate the phosphatidylinositol 3-kinase/protein kinase B（PI3K/Akt） signaling pathway； Ruyi heibai powder can activate the programmed death-1/programmed death-ligand 1（PD-1/PD-L1） signaling pathway； Compound honghua buji granules and demethylzeylasteral can inhibit the Janus kinase/signal transducer and activator of transcription （JAK/STAT） signaling pathway. These mechanisms promote melanin production and deposition， reduce oxidative stress， inhibit the destruction of melanocytes by autoimmunity， and reduce melanocyte apoptosis， thereby exerting therapeutic effects on vitiligo.

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references

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