Effects of prescription pre-review system on rational drug use and off-label drug use management in outpatient and emergency department

GAO Zhi; HAN Lulu; LIU Fang; JIAO Rui; ZHANG Wei; ZHANG Yi

doi:10.6039/j.issn.1001-0408.2025.13.19

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Effects of prescription pre-review system on rational drug use and off-label drug use management in outpatient and emergency department

更新时间：2025-09-24

- Effects of prescription pre-review system on rational drug use and off-label drug use management in outpatient and emergency department
- ZHONGGUO YAOFANG Vol. 36, Issue 13, Pages: 1666-1670(2025)
- 作者机构：
  
  中国医学科学院整形外科医院药剂科，北京　100144
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.13.19
  CLC： R952
- Received：13 December 2024，
  
  Revised：2025-05-12，
  
  Accepted：12 May 2025，
  
  Published：15 July 2025
- 稿件说明：
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高志,韩璐璐,刘芳,等.处方前置审核对门急诊合理用药及超说明书用药管理的影响[J].中国药房,2025,36(13):1666-1670.

GAO Zhi,HAN Lulu,LIU Fang,et al.Effects of prescription pre-review system on rational drug use and off-label drug use management in outpatient and emergency department[J].ZHONGGUO YAOFANG,2025,36(13):1666-1670.
高志,韩璐璐,刘芳,等.处方前置审核对门急诊合理用药及超说明书用药管理的影响[J].中国药房,2025,36(13):1666-1670. DOI： 10.6039/j.issn.1001-0408.2025.13.19.

GAO Zhi,HAN Lulu,LIU Fang,et al.Effects of prescription pre-review system on rational drug use and off-label drug use management in outpatient and emergency department[J].ZHONGGUO YAOFANG,2025,36(13):1666-1670. DOI： 10.6039/j.issn.1001-0408.2025.13.19.

摘要

目的

探讨处方前置审核系统对门急诊合理用药水平及超说明书用药管理的影响。

方法

回顾性分析我院处方前置审核系统上线后在2023年1－5月（静默审查阶段，对照组）、2023年6－10月（系统自动审核阶段，干预组1）、2023年11月－2024年3月（系统自动审核+药师向医师集中反馈不合理处方阶段，干预组2）3个阶段的门急诊处方数据，对系统警示率、处方不合理率、已备案超说明书用药率和假阳性不合理处方率进行比较分析，同时分析不合理处方的构成情况，并对医师提交的新增备案的超说明书用药情况进行循证评价。

结果

与对照组比较，经弹窗提示后，干预组1的系统警示率及处方不合理率均显著降低（

＜0.05）；经系统提示和药师反馈后，干预组2的系统警示率及处方不合理率进一步降低（

＜0.05），但与干预组1比较的差异无统计学意义（

＞0.05）。不合理用药类型以给药途径不合理为主，干预组1与对照组比较、干预组2与干预组1比较，给药途径不合理率均显著降低（

＜0.05）。与对照组比较，干预组1和干预组2的已备案超说明书用药率的差异无统计学意义（

＞0.05），但前置审核软件的实时提示以及药师的定期汇总反馈提高了医师对超说明书用药备案的意识。2023年6月至2024年3月，医师共提交超说明书用药备案13项，均被不同级别证据支持，其中3项被美国FDA说明书批准，4项被Micromedex数据库收录，其余6项均被系统评价或随机对照试验文献证据支持。

结论

处方前置审核系统可显著提高门急诊合理用药水平，助力规范超说明书用药的管理。

Abstract

OBJECTIVE

To explore the effects of prescription pre-review system on rational drug use and off-label drug use management in outpatient and emergency department.

METHODS

A retrospective analysis was conducted on outpatient and emergency department prescription data from three phases in our hospital： January to May 2023 （silent review phase， control group）， June to October 2023 （systematic automatic review phase， intervention group 1）， and November 2023 to March 2024 （phase combining systematic automatic review with centralized feedback from pharmacists to physicians regarding irrational prescriptions， intervention group 2）. These phases followed the implementation of our hospital’s pre-prescription review software. Statistical analysis of the prompt rate of alert， rate of irrational prescriptions， registered the off-label drug use rate and false positive irrationality prescription rate were conducted. Meanwhile， the composition of irrational prescriptions was analyzed， and evidence-based evaluation of the off-label drug use proposed by clinicians was also conducted.

RESULTS

Compared with control group， the prompt rate of alert and the rate of irrational prescriptions in intervention group 1 were all decreased significantly after receiving pop-up notification， with statistically significant differences （

＜0.05）. With the help of system warning and the pharmacists feedback， the prompt rate of alert and the rate of irrational prescriptions declined further in the intervention group 2， but there was no statistically significant difference when compared with intervention group 1 （

＞0.05）. The main type of irrational drug use was improper administration routes. When comparing intervention group 1 with the control group， as well as intervention group 2 with intervention group 1， a significant

decrease in the rate of improper administration routes was observed， with statistically significant differences （

＜0.05）. Compared with control group， there was no significant difference in the registered off-label drug use rate of intervention group 1 and intervention group 2 （

＞0.05）. The doctor’s awareness of off-label drug use registration increased due to the real-time alerts from the pre-prescription review software， along with the pharmacists’ regular summarization and feedback. Total 13 items registrations of off-label drug use were proposed by clinicians from June 2023 to March 2024， all of which were supported by evidence of varying levels； among them， 3 items received FDA approval， 4 items were included in the Micromedex database， and the remaining 6 items were supported by evidence from system reviews or randomized controlled trials.

CONCLUSIONS

Prescription pre-review system can improve the level of rational drug use and assist in the standardized management of off-label drug use.

关键词

Keywords

references

国家卫生健康委员会 . 关于印发医疗机构处方审核规范的通知 [EB/OL ] .（ 2018-07-10 ）[ 2025-05-08 ] . http：//www.nhc.gov.cn/yzygj/s7659/201807/de5c7c9116b547af819f8-25b53741173.shtml http://www.nhc.gov.cn/yzygj/s7659/201807/de5c7c9116b547af819f8-25b53741173.shtml .

国家卫生健康委员会 . 关于加快药学服务高质量发展的意见 [EB/OL ] .（ 2018-11-21 ）[ 2025-05-08 ] . http：//www.nhc.gov.cn/yzygj/s7659/201811/ac342952cc114bd094fec-1be086d2245.shtml http://www.nhc.gov.cn/yzygj/s7659/201811/ac342952cc114bd094fec-1be086d2245.shtml .

冯光富，温慧敏，李儒杰，等 . 人工智能对医院药学的影响分析 [J ] . 中国药房， 2018 ， 29 （ 16 ）： 2167 - 2169 .

魏丽莉，田海燕 . 循证医学视角下的超说明书用药分级管理研究 [J ] . 中国医药指南， 2023 ， 21 （ 8 ）： 96 - 98 .

金轶，丁帆，成仙叶，等 . 聚桂醇注射治疗皮肤血管瘤和静脉畸形临床疗效及安全性的Meta分析 [J ] . 临床皮肤科杂志， 2020 ， 49 （ 3 ）： 133 - 139 .

RULLAN P P ， LEE K C . Successful management of extreme pain from delayed embolization after hyaluronic acid filler injection [J ] . JAAD Case Rep ， 2019 ， 5 （ 7 ）： 569 - 571 .

PAZYAR N ， DEZFULY M B ， HADIBARHAGHTALAB M ， et al . Intradermal injection of 100 mg tranexamic acid versus topical 4% hydroquinone for the treatment of melasma：a randomized，controlled trial [J ] . J Clin Aesthet Dermatol ， 2023 ， 16 （ 1 ）： 35 - 40 .

QU Y ， WANG F J ， LIU J R ， et al . Clinical observation and dermoscopy evaluation of fractional CO 2 laser combined with topical tranexamic acid in melasma treatments [J ] . J Cosmet Dermatol ， 2021 ， 20 （ 4 ）： 1110 - 1116 .

WANITPHAKDEEDECHA R ， SY-ALVARADO F ， PATTHAMALAI P ， et al . The efficacy in treatment of facial melasma with thulium 1 927-nm fractional laser-assisted topical tranexamic acid delivery：a split-face，double-blind，randomized controlled pilot study [J ] . Lasers Med Sci ， 2020 ， 35 （ 9 ）： 2015 - 2021 .

LIAO X ， CHENG F R ， JIANG Y L . Efficacy and safety of mesotherapy with tranexamic acid versus vitamin C in the treatment of melasma：a meta-analysis and systemic review [J ] . J Cosmet Dermatol ， 2024 ， 23 （ 9 ）： 2785 - 2792 .

CORREIA G ， MAGINA S . Efficacy of topical vitamin C in melasma and photoaging：a systematic review [J ] . J Cosmet Dermatol ， 2023 ， 22 （ 7 ）： 1938 - 1945 .

LOWE N J ， YAMAUCHI P S ， LASK G P ， et al . Efficacy and safety of botulinum toxin type A in the treatment of palmar hyperhidrosis：a double-blind，randomized，placebo-controlled study [J ] . Dermatol Surg ， 2002 ， 28 （ 9 ）： 822 - 827 .

BECHARA F G ， PODDA M ， PRENS E P ， et al . Efficacy and safety of adalimumab in conjunction with surgery in moderate to severe hidradenitis suppurativa：the SHARPS randomized clinical trial [J ] . JAMA Surg ， 2021 ， 156 （ 11 ）： 1001 - 1009 .

左玮，刘容吉，孙雅佳，等 . 《中国超药品说明书用药管理指南（2021）》推荐意见及要点解读 [J ] . 协和医学杂志， 2023 ， 14 （ 1 ）： 86 - 93 .

杜朝阳，史强，邵魏，等 . 基于前置处方审核系统的儿童专科医院心内科门急诊超说明书用药合理性分析 [J ] . 中国现代应用药学， 2022 ， 39 （ 12 ）： 1551 - 1557 .

GAO Z ， JIAO R ， ZHANG W ， et al . Retrospective analysis of off-label medication use at a plastic surgery hospital in China and evidence-based evaluation [J ] . Dermatol Ther ， 2021 ， 34 （ 1 ）： e14424 .

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