Pharmacological effects and drug design research progress of fucoxanthin

ZHANG Yuxin; DENG Ziyang; WANG Can; ZENG Dan

doi:10.6039/j.issn.1001-0408.2025.17.23

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Pharmacological effects and drug design research progress of fucoxanthin

更新时间：2025-09-29

- Pharmacological effects and drug design research progress of fucoxanthin
- ZHONGGUO YAOFANG Vol. 36, Issue 17, Pages: 2216-2220(2025)
- 作者机构：
  
  1.重庆大学材料科学与工程学院，重庆　400043
  2.四川大学华西药学院，成都　610207
  3.重庆大学附属人民医院/重庆市人民医院过敏反应科，重庆　401121
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.17.23
  CLC： R965
- Received：09 March 2025，
  
  Revised：2025-07-26，
  
  Accepted：29 July 2025，
  
  Published：15 September 2025
- 稿件说明：
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张育新,邓子洋,王灿,等.岩藻黄素的药理作用及药物设计研究进展[J].中国药房,2025,36(17):2216-2220.

ZHANG Yuxin,DENG Ziyang,WANG Can,et al.Pharmacological effects and drug design research progress of fucoxanthin[J].ZHONGGUO YAOFANG,2025,36(17):2216-2220.
张育新,邓子洋,王灿,等.岩藻黄素的药理作用及药物设计研究进展[J].中国药房,2025,36(17):2216-2220. DOI： 10.6039/j.issn.1001-0408.2025.17.23.

ZHANG Yuxin,DENG Ziyang,WANG Can,et al.Pharmacological effects and drug design research progress of fucoxanthin[J].ZHONGGUO YAOFANG,2025,36(17):2216-2220. DOI： 10.6039/j.issn.1001-0408.2025.17.23.

摘要

岩藻黄素是一种广泛存在于藻类、海洋浮游生物和水生贝壳等动植物中的类胡萝卜素，在医药领域具有巨大的开发潜力。本文综述了岩藻黄素在抗炎、抗氧化、抗肿瘤和抗肥胖方面的药理作用及其在药物设计方面的研究进展，发现其可通过激活AMP活化的蛋白质激酶等相关信号通路、调控炎症因子表达、改善菌群稳态等发挥抗炎、抗氧化作用，从而改善代谢相关脂肪性肝病、结肠炎等；可通过多靶点协同作用发挥选择性抗肿瘤效应；可通过调控肠道菌群等发挥抗肥胖作用；其特征性官能团（如羟基、环氧基团等）具有靶点选择性与可逆抑制活性，可作为优化模板指导新型药物设计开发，为突破传统药物设计局限提供了新思路。

Abstract

Fucoxanthin is a pigment found in plants and animals such as algae， marine plankton and aquatic shellfish， and holds significant potential for development in the pharmaceutical field. This review introduces the anti-inflammatory， antioxidant， anticancer， anti-obesity， and other pharmacological effects of fucoxanthin， as well as recent advances in drug design research. It was found that fucoxanthin can exert anti-inflammatory and antioxidant effects through mechanisms such as activating AMP-activated protein kinase related signaling pathways， regulating the expression of inflammatory factors， altering microbial stability， thereby improving conditions such as metabolic associated fatty liver disease and colitis. It can exert selective antitumor effects through multi-target synergistic actions； and it was also found that it can exert anti-obesity effects by regulating the intestinal microbiota. Its characteristic functional groups （such as hydroxyl and epoxy groups） possess target specificity and reversible inhibitory properties， making it a suitable template for guiding the design and development of novel drugs， thereby providing new insights for breaking through the limitations of traditional drug design.

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references

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