Advances in research on the potential effects and mechanism of asiaticoside in acute kidney injury

ZHOU Yingying; ZHANG Xinying; QIAN Yingying; XIE Xiangcheng

doi:10.6039/j.issn.1001-0408.2025.19.22

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Advances in research on the potential effects and mechanism of asiaticoside in acute kidney injury

更新时间：2025-10-11

- Advances in research on the potential effects and mechanism of asiaticoside in acute kidney injury
- ZHONGGUO YAOFANG Vol. 36, Issue 19, Pages: 2484-2488(2025)
- 作者机构：
  
  1.浙江中医药大学第四临床医学院，杭州　310053
  2.西湖大学医学院附属杭州市第一人民医院肾内科，杭州　310006
  3.浙江大学医学院附属邵逸夫医院肾内科，杭州　310016
- 作者简介：
- 基金信息：
- DOI：10.6039/j.issn.1001-0408.2025.19.22
  CLC： R285;R965
- Received：16 April 2025，
  
  Revised：2025-08-18，
  
  Accepted：18 August 2025，
  
  Published：15 October 2025
- 稿件说明：
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周盈盈,章鑫莹,钱盈盈,等.积雪草苷在急性肾损伤中的潜在作用及机制研究进展[J].中国药房,2025,36(19):2484-2488.

ZHOU Yingying,ZHANG Xinying,QIAN Yingying,et al.Advances in research on the potential effects and mechanism of asiaticoside in acute kidney injury[J].ZHONGGUO YAOFANG,2025,36(19):2484-2488.
周盈盈,章鑫莹,钱盈盈,等.积雪草苷在急性肾损伤中的潜在作用及机制研究进展[J].中国药房,2025,36(19):2484-2488. DOI： 10.6039/j.issn.1001-0408.2025.19.22.

ZHOU Yingying,ZHANG Xinying,QIAN Yingying,et al.Advances in research on the potential effects and mechanism of asiaticoside in acute kidney injury[J].ZHONGGUO YAOFANG,2025,36(19):2484-2488. DOI： 10.6039/j.issn.1001-0408.2025.19.22.

摘要

急性肾损伤（AKI）是一类以肾功能在短时间内迅速下降为特征的临床综合征，其发病机制涉及氧化应激、炎症反应及细胞程序性死亡等多个环节，且目前缺乏特效治疗药物。现有研究表明，积雪草苷作为天然活性成分，在AKI干预中展现出多靶点保护潜力。其作用机制包括激活核转录因子红系2相关因子2/血红素加氧酶1等抗氧化通路以减轻氧化损伤，调控核因子κB/NOD样受体热蛋白结构域相关蛋白3、Janus激酶2/信号转导和转录激活因子3等关键炎症通路以抑制炎症反应并调节巨噬细胞极化，以及通过影响凋亡相关蛋白表达和激活沉默调节蛋白1-叉头框蛋白O3-人第10号染色体缺失的磷酸酶及张力蛋白同源基因诱导的激酶1-Parkin通路促进线粒体自噬以维持细胞稳态。积雪草苷作为一种多靶点天然化合物，有望为AKI的临床治疗提供新的干预策略，但仍需大样本临床试验验证其疗效及安全性。

Abstract

Acute kidney injury （AKI） is a clinical syndrome characterized by a rapid decline in renal function within a short period. Its pathogenesis involves multiple processes， including oxidative stress， inflammatory responses， and programmed cell death， while effective pharmacological interventions remain lacking. Current studies have indicated that asiaticoside， a natural active compound， exhibits nephroprotective potential in the intervention of AKI. The potential mechanisms include the activation of antioxidant signaling such as nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 to mitigate oxidative injury， the regulation of key inflammatory pathways including nuclear factor-κB/NOD-like receptor thermal protein domain associated protein 3， and Janus kinase 2/signal transducer and activator of transcription 3 to suppress inflammation and modulate macrophage polarization； it promotes mitophagy by influencing the expression of apoptosis-related proteins and activating the recombinant sirtuin 1-forkhead box-O3-phosphatase and tensin homolog-induced kinase 1-Parkin pathway so as to maintain cellular homeostasis. As a multi-target natural compound， asiaticoside holds promise for providing novel intervention strategies in the clinical treatment of AKI， yet its efficacy and safety still require validation through large-sample clinical trials.

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references

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