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Effects of meropenem exposure and degradation levels on clinical efficacy in patients with purulent meningitis
更新时间：2025-12-26

    • Effects of meropenem exposure and degradation levels on clinical efficacy in patients with purulent meningitis

    • “According to the latest research, insufficient exposure and rapid degradation of meropenem are key factors affecting the efficacy of purulent meningitis. Elevated concentration/trough concentration ratio of open-loop metabolites in the blood, low serum creatinine levels, lack of intrathecal injection, and low glucose content in cerebrospinal fluid are independent risk factors for poor efficacy.”
    • ZHONGGUO YAOFANG   Vol. 36, Issue 24, Pages: 3084-3090(2025)

    • DOI：10.6039/j.issn.1001-0408.2025.24.12    

      CLC： R969;R978.1

    • Received：24 July 2025，

      Revised：2025-08-12，

      Accepted：21 November 2025，

      Published：30 December 2025

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  • LI Tongtong,SUN Jiantong,CHEN Xianglong,et al.Effects of meropenem exposure and degradation levels on clinical efficacy in patients with purulent meningitis[J].ZHONGGUO YAOFANG,2025,36(24):3084-3090. DOI： 10.6039/j.issn.1001-0408.2025.24.12.

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Related Author

HU Zhicheng
CHEN Yongwu
HU Tongtong
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CAI Ningfang
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Related Institution

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