“Portal vein thrombosis (PVT) is a common and serious complication of liver cirrhosis, and its anticoagulant therapy is quite challenging. Based on the comprehensive research results and consensus guidelines of experts, this review focuses on the high incidence reasons, clinical manifestations and diagnosis, anticoagulation treatment decisions, and rational use of drugs for liver cirrhosis complicated with PVT, providing guidance for anticoagulation treatment of liver cirrhosis complicated with PVT.”