“Natural products have great potential in the development of anti-tumor drugs, but there are many limitations to their clinical application. Cell membrane biomimetic nanoparticles, as a novel drug delivery system, provide a new strategy for breaking through the bottleneck of natural product delivery. Experts systematically reviewed the preparation methods and characterization techniques of biomimetic nanoparticles on cell membranes, with a focus on their application in natural product anti-tumor delivery, providing an efficient and safe new delivery pathway for natural product anti-tumor therapy.”